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The project, funded by the Wellcome Trust under its functional genomics and development initiative, is an interdisciplinary collaboration between clinicians, basic scientists and bioinformaticians working throughout the UK on the genetic determinants of hypertension and its cardiac and vascular complications. It builds on the wealth of information obtained in rodent models that were used to characterise chromosomal regions involved in the control of phenotypes underlying metabolic and cardiovascular disorders. Translating results from experimental work to human disease represents a major challenge in biomedical research and should provide substantial advances in the prevention, diagnosis and treatment of metabolic and cardiovascular diseases.

The consortium involves five universities in the UK (Imperial College London and the Universities of Edinburgh, Glasgow, Leicester and Oxford) and will apply a functional genomic approach to the analysis of hypertension and its cardiac and vascular complications as well as primary pulmonary hypertension and hypertrophic cardiomyopathy.

General information about this functional genomics programme can be obtained at http://www.gla.ac.uk/faculties/medicine/cfg.html.

Relevant publications