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Genetics of Complex Traits in Model OrganismsGauguier group Polycystic Kidney DiseaseAutosomal Dominant Polycystic Kidney Disease is the most common genetic disease that leads to kidney failure in humans. In addition to the known causative genes PKD1 and PKD2, there are further mutations resulting in cystic formation in the kidney, such as nephronophthisis, autosomal recessive polycystic kidney disease or medullary cystic kidney disease. Genetic and physiological studies in rodent models of PKD will help to improve our understanding of renal cystogenesis and will lead to subsequent therapeutic developments.
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