Background

Whole genome association studies

With recent advances in the efficiency of high-throughput single nucleotide polymorphism (SNP) genotyping technology, genome-wide association studies are now routinely undertaken with the sample sizes necessary to detect the modest genetic effects we expect for complex diseases. There is now a clear demand for efficient analysis tools that allow data pre-treatment, together with evaluation, visualization and interpretation of results. To meet these demands, we have further developed the GOLDsurfer software [1]. GOLDsurfer2 can be used in all steps of whole genome association studies from data import to evaluation of statistical findings.

The project

The Goldsurfer2 project was initiated as a collaboration between Glaxo Smithkline and Oxford University. The software is publicly available and a beta version is free to download from this webpage.

GS2 is developed from goldsurfer.
Pettersson, F., Jonsson, O. and Cardon, L.R., GOLDsurfer: three dimensional display of linkage disequilibrium.
Bioinformatics. 2004;20(17):3241-3

Reference by

A manuscript is under preparation and have the tentative title:

GOLDsurfer2: A comprehensive tool for the analysis and visualization of whole genome association studies
F. Pettersson1, A.P. Morris1, M.R. Barnes2, L.R. Cardon1
1)Dept Bioinformatics, Wellcome Trust Centre, Oxford, United Kingdom;
2) Molecular Discovery Informatics, GlaxoSmithKline Pharmaceuticals, Harlow, Essex, United Kingdom

Feedback on bugs, new features and usability issues is happily received. (fredrikp@well.ox.ac.uk).Keep browsing for new updates.