Ashish Kumar's Home Page
I am working in the domain of complex disease medical research, with specialization in bioinformatics and statistical genetics. Currently, I am part of two research groups and share my time between:
Earlier, I was in the Department of Cardiovascular Medicine, working with Prof. Martin Farrall on a EU Framework 6 grant called GABRIEL, co-ordinated by Prof. Bill Cookson. The project aimed at investigating the genetic and environmental causes of asthma in the European Community.
Asthma is caused by a combination of genetic and environmental effects, and despite being rare a hundred years ago; it has become increasingly common in developed societies across the world. It is believed that rural environments are strongly protective against the disease, and increasing urbanisation may be contributing to the rise in the numbers affected.
The first phase of genetic analysis involved GWAS (Genome-Wide Association Studies) across 994 cases and 1243 controls (from 2 cohorts), and led to the discovery of link between ORMDL3 and childhood asthma. The findings have been published in an article in Nature journal.
The second phase involved 22 cohorts for GWAS across approximately 25000 cases and controls. For this, the genotyping was done on Illumina 610-Quad BeadChips at CNG, Paris. These findings were recently published in an article in NEJM.
I’ve commissioned and manage various high computing servers like DellTM PowerEdgeTM R905 (four Six-Core AMD Opteron™ 8000 Series processors, 128 GB RAM) and Sun Fire V40z server (four dual-core AMD OpteronTM 64-bit CPUs, 16 GB RAM) with Red Hat Enterprise Linux 5. Also attached are various capacities of "Storage Array" solutions for upto 12 TB space.
Responsibility and research interests:
Previously, I have worked in the industry for around 8 yrs; in the UK as Bioinformatician / IT analyst with companies like Unilever & Volkswagen; in India with some promising start-ups like Omeganet India (now merged into Onicra), LinkEdge Technologies, Career Launcher and Netaquila Solutions; providing IT consultancy, project management, business development and client account management (in business process automation, ERP - Enterprise Resource Planning, database development, data migration and ware-housing, b2b).
Tel: +44 (0) 1865 287715
Industry Research - at Unilever