YanYan

Dr Yanyan Jiang, Dphil

Post-doc

Research summary

I obtained a BSc (Pharmacy) and MSc (Pharmacology) in China. In 2002, I came to Oxford as a research assistant, and worked in the Department of Clinical Neurology and the Department of Anatomy before conducting my Dphil studies in the Pharmacology Department. Following the completion of my Dphil, I joined Watkins’ group in 2008. The focus of my current research is to investigate the mechanism of hypertrophic cardiomyopathy (HCM) caused by sarcomeric mutations.

HCM is the most common cause of sudden death in young adults. While mutations in the sarcameric protein genes have been linked to HCM, the pathogenesis of sarcomeric mutations causing HCM remains unclear, and there is no curative therapy for HCM at present. We have proposed that sarcomeric mutations in HCM lead to increased energy demand and ultimately cause energy deficiency which contributes to the pathogenesis of HCM. We will test this hypothesis in a model with inducible expression of HCM-mutant troponin T. It is hoped that the results of this study will lead to novel strategies for therapies in HCM.

Publication List

Jiang, Y., Deacon, R., Anthony, D. C. & Campbell, S. J. 2008. 'Inhibition of peripheral TNF can block the malaise associated with CNS inflammatory diseases'. Neurobiol Dis vol 32, pp 125-132. View on Pubmed

Campbell, S. J., Zahid, I., Losey, P. & other authors 2008. 'Liver Kupffer cells control the magnitude of the inflammatory response in the injured brain and spinal cord'. Neuropharmacology vol 55, pp 780-787. View on Pubmed

Campbell, S. J., Deacon, R. M., Jiang, Y., Ferrari, C., Pitossi, F. J. & Anthony, D. C. 2007. 'Overexpression of IL-1beta by adenoviral-mediated gene transfer in the rat brain causes a prolonged hepatic chemokine response, axonal injury and the suppression of spontaneous behaviour'. Neurobiol Dis vol 27, pp 151-163. View on Pubmed

Campbell, S. J., Jiang, Y., Davis, A. E., Farrands, R., Holbrook, J., Leppert, D. & Anthony, D. C. 2007. 'Immunomodulatory effects of etanercept in a model of brain injury act through attenuation of the acute-phase response'. J Neurochem vol 103, pp 2245-2255. View on Pubmed

Jiang, Y., Oliver, P., Davies, K. E. & Platt, N. 2006. 'Identification and characterization of murine SCARA5, a novel class A scavenger receptor that is expressed by populations of epithelial cells'. J Biol Chem vol 281, pp 11834-11845. View on Pubmed

(more)

Research Areas

Cardiovascular science, neuroscience

Contact Details

Email yanyan.jiang@cardiov.ox.ac.uk

Sponsor

British Heart Foundation