witoldWitold Czyz

DPhil awarded 2014 

Epstein-Barr Virus (EBV) is a ubiquitous herpesvirus which infects over 95% of adult human population. It has been implicated in aetiology of Infectious Mononucleosis and oncogenesis of lymphoid and epithelial tumours including Burkitt's lymphoma, post-transplant B-cell lymphomas, Hodgkin's disease and nasopharyngeal carcinoma, and linked to several other diseases including Multiple Sclerosis. While it is evident that EBV viral load and latency gene expression may be important risk factors directly contributing to the pathology of EBV-related disease, the genetic determinants of susceptibility to EBV infection, EBV uptake and proliferative capacity remain a relatively understudied subject. My research focuses on exploring the links between genetic diversity and differential activity of the virus.

Previously, I have completed a 3-year undergraduate BSc course in Biotechnology at Cardiff University and at present I am enrolled on a 4-year DPhil course in Medical Genomics and Statistics, sponsored by the Wellcome Trust.

Keywords: Epstein-Barr virus, genetics, lymphoma, multiple sclerosis