Morris group

Teressa

Teresa Ferreira

Post-doctoral researcher

Email

The main focus of my work at present is the genetics of Type 2 Diabetes (T2D).

I am currently involved in the analysis of GWA studies for T2D, contributing to the Diabetes Genetics Replication and Meta-analysis Consortium (DIAGRAM+).

An increasing number of loci with significant evidence of association with Type 2 Diabetes (T2D) have been identified. Despite enormous progress, a large proportion of the heritability of T2D remains unexplained.

Making use of established T2D signals can increase the power to detect others that remain unidentified. A meta-analysis of the genome-wide studies for T2D, conditional on the genotypes of established T2D susceptibility loci, is being carried out. 

Single-locus analysis has been a preferential choice for genome-wide association studies. By ignoring gene-gene interactions we may miss the identification of some causal variants. A gene-gene interaction analysis for T2D is also part of my current work.

Selected publications

Shungin*, D., Winkler*, T.W., Croteau-Chonka*, D.C., Ferreira*, T., Locke*, A.E., Mägi*, R. et al. New Genetic Loci Link Adipocyte and Insulin Biology to Body Fat Distribution. Nature (Accepted)

Locke, A., Kahali. B., Berndt, S., Justice, A., Day, F., Pers, T., Powell, C., Vedantam, S.,Buchkovich, M., Yang, J., Croteau-Chonka, D., Esko, T., Fall, T., Ferreira, T. et al. Large-Scale Genetic Studies of Body Mass Index Provide Insight into the Biological Basis of Obesity. Nature (Accepted).

Wei, Y., Xia, Y., Bell, C. G., Yet, I., Ferreira, T. et al. An Integrated Epigenomic Analysis for Type 2 Diabetes Susceptibility Loci in Monozygotic Twins. Nature Communications (Accepted).

Gaulton*, K. J., Ferreira*, T., Lee*, Y., Raimondo*, A., Mägi*, R., Reschen*, M.E. et al. Genetic Fine-Mapping and Functional Annotation Defines Causal Regulatory Mechanisms at Type 2 Diabetes Susceptibility Loci. (In press).

Perry, J. R., Day, F., Elks, C.E., Sulem, P., Thompson, D. J., Ferreira, T. et al. Parent-of-Origin-Specific Allelic Associations among 106 Genomic Loci for Age at Menarche. Nature 514, no. 7520 (2014): 92-7.

Winkler, T. W., Day, F. R., Croteau-Chonka, D. C., Wood, A. R., Locke, A. E., Magi, R., Ferreira, T. et al. Quality Control and Conduct of Genome-Wide Association Meta-Analyses. Nat Protoc 9, no. 5 (2014): 1192-212.

Berndt, S. I., Gustafsson, S., Magi, R., Ganna, A., Wheeler, E., Feitosa, M. F., Justice, A. E., Monda, K. L., Croteau-Chonka, D. C., Day, F. R., Esko, T., Fall, T., Ferreira, T. et al. Genome-Wide Meta-Analysis Identifies 11 New Loci for Anthropometric Traits and Provides Insights into Genetic Architecture. Nat Genet 45, no. 5 (2013): 501-12.

Morris*, A. P., Voight*, B. F., Teslovich*, T. M., Ferreira*, T., Segre*, A. V. et al. Large-Scale Association Analysis Provides Insights into the Genetic Architecture and Pathophysiology of Type 2 Diabetes. Nat Genet 44, no. 9 (2012): 981-90.

Yang, J., Ferreira, T. et al. Conditional and Joint Multiple-Snp Analysis of Gwas Summary Statistics Identifies Additional Variants Influencing Complex Traits. Nat Genet 44, no. 4 (2012): 369-75, S1-3.

Ferreira, T. and Marchini, J. Modeling Interactions with Known Risk Loci - a Bayesian Model Averaging Approach. Ann Hum Genet 75, no. 1 (2011): 1-9.

Chapman, K., Ferreira, T., Morris, A., Asimit, J. and Zeggini, E. Defining the Power Limits of Genome-Wide Association Scan Meta-Analyses. Genet Epidemiol 35, no. 8 (2011): 781-9.

Southam, L., Panoutsopoulou, K., Rayner, N. W., Chapman, K., Durrant, C., Ferreira, T., et al. The Effect of Genome-Wide Association Scan Quality Control on Imputation Outcome for Common Variants. Eur J Hum Genet 19, no. 5 (2011): 610-4.

Voight, B. F., Scott, L. J., Steinthorsdottir, V., Morris, A. P., Dina, C., Welch, R. P., Zeggini, E., Huth, C., Aulchenko, Y. S., Thorleifsson, G., McCulloch, L. J., Ferreira, T. et al. Twelve Type 2 Diabetes Susceptibility Loci Identified through Large-Scale Association Analysis. Nat Genet 42, no. 7 (2010): 579-89.

The Wellcome Trust Case Control Consortium (2007) Genome wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447; 661-78.

*The authors contributed equally to the work.