Sreeram Ramagopalan
Post-Doctoral Fellow
Research
In my research I am attempting to identify and elucidate the function
of genetic factors that influence susceptibility to multiple sclerosis
(MS) or determine other aspects of the disease. Epidemiological evidence
indicates that the genetic architecture underlying susceptibility to MS is complex with
gene-gene and gene-environment interactions at play. It is well established
that certain HLA genes are more common in patients with the disease, and
indeed this region exerts the single strongest genetic effect
on disease risk, but quite how these antigens alter the risk of developing
MS is not yet fully understood and this forms the main basis of my
research.
Publications
SV Ramagopalan, et al. 2009 "Expression of the multiple sclerosis
associated MHC class II allele HLA-DRB1*1501 is regulated by vitamin D."
PLoS Genetics
YS Aulchenko*, IA Hoppenbrouwers*, SV Ramagopalan, et al. 2008 “Genetic
variation in the KIF1B locus influences susceptibility to multiple
sclerosis.” Nature Genetics (*=co-first author)
SV Ramagopalan, et al. 2008 “Genetic Epidemiology: the use of old and new
tools for multiple sclerosis” Trends in Neurosciences
SV Ramagopalan, et al. 2007 "The inheritance of resistance alleles in
multiple sclerosis" PLoS Genetics
SV Ramagopalan, et al. 2007 “Autoimmune disease in families with multiple
sclerosis: a population-based study” Lancet Neurology
GC DeLuca*, SV Ramagopalan*, et al. 2007 "An extremes of outcome strategy
provides evidence that multiple sclerosis severity is determined by
alleles at the HLA-DRB1 locus" PNAS (*=co-first author)