McCarthy group

Søren Thomsen

Soren Thomsen

DPhil student

Address:

Oxford Centre for Diabetes, Endocrinology & Metabolism, University of Oxford, Churchill Hospital, Headington, Oxford, OX3 7LJ

&

Wellcome Trust Centre for Human Genetics, Roosevelt Dr.
Oxford, OX3 7BN

Email

Research overview

Søren Thomsen was born in Denmark, and received both his Bachelor’s degree (BA in Natural Sciences, Part II Biochemistry, 2012) and Master’s degree (MSci in Natural Sciences, Part III Systems Biology, 2013) from the University of Cambridge, UK. During those years, Søren undertook research projects on a diverse range of topics, including RNA-based self-replication at the MRC LMB in Cambridge (supervised by Dr Philipp Holliger, 2012/13), and the mitogenic effects of insulin signalling, at both Joslin Diabetes Center (supervised by Professor Ronald Kahn, 2012) and the Hagedorn Research Institute (supervised by Professor Pierre de Meyts, 2011).

Since then, Søren has taken up his current position as a DPhil student at the Oxford Centre for Diabetes, Endocrinology & Metabolism, under the supervision of Professor Anna Gloyn and Professor Mark McCarthy. Broadly, the aim of his project is to study the molecular mechanisms through which genetic association signals exert their effect on type 2 diabetes (T2D) risk. Most of such currently established signals map to intergenic regions, and inferring the effector transcripts thus presents a significant challenge. One major focus of Søren’s project is to apply high-throughput screening and single-cell resolution techniques to study genes at T2D-associated regions, thereby assessing the potential role of regional transcripts in insulin secretion and beta-cell identity. In this way, the gene-level information can be used to establish biological priors, which can be integrated with existing genetic and genomic information to prioritise effector-transcript candidates at T2D loci. Informed by this approach, a second part of Søren’s work will use genome editing and other approaches to validate and study selected candidates in greater detail.

In his free time, Søren is a keen sportsperson, currently focusing on mountain biking, hiking and squash. He is also an amateur astronomer and interested in various aspects of academic entrepreneurship.

Selected publications

Thomsen SK and Gloyn AL. The pancreatic beta cell: recent insights from human genetics. Trends Endocrinol Metab 2014;25:425-434.

Raimondo A, Chakera AJ, Thomsen SK et al. Phenotypic severity of homozygous GCK mutations causing neonatal or childhood-onset diabetes is primarily mediated through effects on protein stability. Hum Mol Genet 2014;Jpii: ddu360.