Photograph of Seiko MakinoSeiko Makino

D. Phil Student

Cell-type specific eQTLs in innate immune responses

Inflammation is dependent on a number of innate immune cell types. Transcriptome analysis on differentially developed primary lymphocytes will provide an insight into cell specific expression patterns in innate immune responses and help us to understand expression quantitative trait loci (eQTLs) in functionally relevant cells. This project I am involved aims to indentify splicing variations and allele-specific expression in a cell specific manner using primary cells, monocytes, B-cells and natural killer cells from healthy volunteers.

Previously I worked as a research technician in the Cardiovascular Research Center at Massachusetts General Hospital in Boston, Massachusetts, USA. The research was focused on the genetic basis of lone atrial fibrillation. For my master degree I studied on the molecular interaction of bacterial phytopathogen Xanthomonas oryzae and its host plant rice (Oryza sativa) in Iowa State University, Ames, Iowa, USA.


Keywords: eQTL, immunity, splicing, allele-specific gene expression