Research projects

Genome-wide association (GWA) and replication studies, to uncover novel genetic variants
In 2008, we were funded by the Wellcome Trust to conduct the first GWA study of endometriosis. This study, involving >5,500 women with endometriosis recruited by the International Endogene Consortium, aims to uncover common genetic variants across the genome that increase susceptibility to endometriosis. Read more...

Fine-mapping and resequencing studies on chromosomes 7 and 10
In our previous work in collaboration with the Queensland Institute for Medical Research (Brisbane, Australia), we identified two regions of significant linkage to endometriosis, on chromosomes 7 and 10. We are currently following up these signals. Read more...

 

 

Genetic and epidemiological analyses in an extended pedigree of rhesus macaques with spontaneous endometriosis
The rhesus macaque develops endometriosis spontaneously, identical to women. In 2004, we established familial aggregation of endometriosis in the rhesus macaque for the first time using genealogical pedigree information. We are now conducting genetic studies to investigate novel and previously implicated areas of the genome, as well as epidemiological risk-factor studies. Read more...

Multi-centre studies of the global impact of endometriosis and predictive value of associated symptoms
Funded by the World Endometriosis Research Fund and the EU Public Health Programme, we are conducting two prospective, multi-centre epidemiological studies on the impact of endometriosis (the Global Study of Women's Health), and the predictive value of a symptom-based tool in diagnosis (the Women's Health Symptom Survey). Read more...

Genetical genomics and molecular phenotyping in epidemiological studies
We are interested how genetic, molecular, and environmental information from epidemiological-scale studies can be integrated to understand the aetiology of complex traits such as endometriosis, and how this information ultimately can be used to find biomarkers for disease and surrogate markers for treatment effectiveness studies. To this end we have been involved in various 'molecular phenotyping' variability studies, involving transcriptomic, metabonomic and proteomic data. Read more...