UNIVERSITY OF OXFORD
Research Associate in Statistical Genomics (GWAS)
The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN
Grade 7: £29,099 to £35,788 with a discretionary range to £39,107 per annum
Applications are invited for a Research Associate in Statistical Genomics (GWAS) for MalariaGEN, a data-sharing community working to develop new tools to control malaria by integrating epidemiology with genome science (www.malariagen.net).
You will be based in the MalariaGEN analysis team which is jointly led by Dominic Kwiatkowski, Chris Spencer and Gil McVean. You will focus on developing and implementing analytical methods in Plasmodium and Anopheles genome-wide association analysis based on next-generation sequencing data, taking into account the complex population structure and evolutionary biology of parasite and mosquito populations. You will interact closely with other team members at the Wellcome Trust Centre for Human Genetics, and also with colleagues based at the Sanger Institute and the Mahidol-Oxford Research Unit in Bangkok, and with MalariaGEN partners around the world.
You should have a minimum of a PhD in statistics, population genetics or other relevant area of quantitative analysis, and strong skills in computer programming for advanced statistical analysis and large-scale data management.
The position is available for up to three years in the first instance and is funded by The Wellcome Trust.
To apply for this role and for further details, including a job description and person specification, please click on the link below:
https://www.recruit.ox.ac.uk/pls/hrisliverecruit/erq_jobspec_version_4.jobspec?p_id=101905
Only applications received before 12:00, midday on Thursday 16th February 2012 can be considered. You will be required to upload a CV and supporting statement as part of your online application, please quote reference 101905 in all correspondence.
Interviews will be held on the 24th and 28th February 2012.
Informal enquiries can be made to Professor Dominic Kwiatkowski, Director of MalariaGEN (dominic@well.ox.ac.uk).
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UNIVERSITY OF OXFORD
Research Associate in Statistical Genetics
The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN
Grade 7: £29,099 to £35,788 with a discretionary range to £39,107 per annum
Applications are invited for a Research Associate in Statistical Genetics to join the group of Prof Gil McVean.
You will provide statistical genetics support for Professor Gil McVean across a wide range of collaborative projects, primarily the analysis of large-scale genomic data sets arising from medical genetics studies (collaborators including WTCCC2, P. Donnelly, D. Kwiatkowski, S. Sawcer, J. Trowsdale, M. McCarthy, L. Fugger, A. Wilkie, Illumina, GSK). Examples of work required include: performing and analysing imputation of data in association studies, prioritising variants for follow-up functional work identified in deep sequencing of germ-line or tumour samples of patients with a variety of disorders, analysing de novo assembly graph structures to assess evidence for specific rearrangements in somatic cells, analysis of single-cell sequencing data to detect recombination events. You will also contribute to scientific publications, present at local and international conferences and take lead responsibility on particular projects.
You will have a first degree in statistics, computer science, physics or maths and have experience with statistical modelling and inference, research experience in the statistical analysis of human genetic variation and low-level programming language such as C or C++. You will also have the ability to manage the day-to-day running of a research project.
The position is available for up to three years in the first instance and is funded by the Department. Full or part-time hours (22.5 to 37.5 hrs per week) are available (on a pro rata basis).
To apply for this role and for further details, including a job description and person specification, please click on the link below:
https://www.recruit.ox.ac.uk/pls/hrisliverecruit/erq_jobspec_version_4.jobspec?p_id=101908
Only applications received before 12:00, midday on Thursday 16th February 2012 can be considered.
You will be required to upload a CV and supporting statement as part of your online application, please quote reference 101908 in all correspondence.
Interviews will be held on the 24th and 28th February 2012.
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UNIVERSITY OF OXFORD
Research Associate in Statistical Genomics (NGS)
The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN
Grade 7: £29,099 to £35,788 with a discretionary range to £39,107 per annum
Applications are invited for a Research Associate in Statistical Genomics (NGS) for MalariaGEN, a data-sharing community working to develop new tools to control malaria by integrating epidemiology with genome science (www.malariagen.net).
You will be based in the MalariaGEN analysis team which is jointly led by Dominic Kwiatkowski, Chris Spencer and Gil McVean. You will focus on developing and implementing analytical methods in Plasmodium and Anopheles next-generation sequencing, specifically planning and implementing analysis of next generation sequencing data in Plasmodium and Anopheles populations, including new statistical approaches in variant discovery, de novo assembly, and genotyping quality control. You will interact closely with other team members at the Wellcome Trust Centre for Human Genetics, and also with colleagues based at the Sanger Institute and the Mahidol-Oxford Research Unit in Bangkok, and with MalariaGEN partners around the world.
You should have a minimum of a PhD in statistics, population genetics or other relevant area of quantitative analysis, and strong skills in computer programming for advanced statistical analysis and large-scale data management.
The position is available for up to three years in the first instance and is funded by The Wellcome Trust.
To apply for this role and for further details, including a job description and person specification, please click on the link below:
https://www.recruit.ox.ac.uk/pls/hrisliverecruit/erq_jobspec_version_4.jobspec?p_id=101909
Only applications received before 12:00, midday on Thursday 16th February 2012 can be considered. You will be required to upload a CV and supporting statement as part of your online application, please quote reference 101909 in all correspondence.
Interviews will be held on the 24th and 28th February 2012.
Informal enquiries can be made to Professor Dominic Kwiatkowski, Director of MalariaGEN (dominic@well.ox.ac.uk).
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UNIVERSITY OF OXFORD
Senior Postdoctoral Research Scientist
The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN
Grade 8: £36,862 to £44,016 with a discretionary range to £48,096 per annum
Applications are invited for a Senior Postdoctoral Research Scientist to join the group of Prof Gil McVean to further the development and application of statistical and computational methodology for de novo assembly from high throughput sequencing data.
You will further develop statistical and computational methodology to perform de novo assembly from high throughput sequencing data. This work builds on the development (by Z. Iqbal, G. McVean and others) of the software Cortex (Iqbal et al. 2011, Nature Genetics), which uses a new concept of 'coloured' de Bruijn graphs to simultaneously assemble multiple genomes. Applications of the software include discovery of novel sequence in species with assembled genomes, discovery of genetic variation in species without assembled genomes, tracking hypervariable immune-related genes in pathogens, identifying somatic mutations in tumour-normal pairs and assembling mRNA transcripts from RNAseq data. You will lead future developments of the Cortex software, provide supervision to students and postdocs working on diverse applications on the methodology arising through collaboration and be primarily responsible for documenting and maintaining released software.
You will have a first degree in computer science, physics or statistics and have experience with software development on a substantial scale. You will have extensive experience with C; and experience with or ability and willingness to learn Python. You will manage the day-to-day running of the research project and have good communication skills.
The position is available for up to three years in the first instance and is funded by the Department.
To apply for this role and for further details, including a job description and person specification, please click on the link below:
https://www.recruit.ox.ac.uk/pls/hrisliverecruit/erq_jobspec_version_4.jobspec?p_id=101911
Only applications received before 12:00, midday on Thursday 16th February 2012 can be considered. You will be required to upload a CV and supporting statement as part of your online application, please quote reference 101911 in all correspondence.
Interviews will be held on the 24th and 28th February 2012.
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UNIVERSITY OF OXFORD
Senior Research Associate in Statistical Genomics (Human Population Genetics)
The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN
Grade 8: £36,862 to £44,016 with a discretionary range to £48,096 per annum
Applications are invited for a Senior Research Associate in Statistical Genomics (Human Population Genetics) for MalariaGEN, a data-sharing community working to develop new tools to control malaria by integrating epidemiology with genome science (www.malariagen.net).
You will be based in the MalariaGEN analysis team which is jointly led by Dominic Kwiatkowski, Chris Spencer and Gil McVean. You will focus on developing and implementing analytical methods in human population genomics. This will involve working with the group leader to define, plan and implement one or more specific analytical projects that will make a significant contribution to MalariaGEN's scientific objectives in the area of human population genomics. You will interact closely with other team members at the Wellcome Trust Centre for Human Genetics, and also with colleagues based at the Sanger Institute and the Mahidol-Oxford Research Unit in Bangkok, and with MalariaGEN partners around the world.
You should have a minimum of a PhD in statistics, population genetics or other relevant area of quantitative analysis and be able to execute complex analytical projects involving multiple partners. You will also have strong skills in computer programming for advanced statistical analysis and large-scale data management.
The position is available for up to three years in the first instance and is funded by The Wellcome Trust.
To apply for this role and for further details, including a job description and person specification, please click on the link below:
https://www.recruit.ox.ac.uk/pls/hrisliverecruit/erq_jobspec_version_4.jobspec?p_id=101912
Only applications received before 12:00, midday on Thursday 16th February 2012 can be considered. You will be required to upload a CV and supporting statement as part of your online application, please quote reference 101912 in all correspondence.
Interviews will be held on the 24th and 28th February 2012.
Informal enquiries can be made to Professor Dominic Kwiatkowski, Director of MalariaGEN (dominic@well.ox.ac.uk).
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UNIVERSITY OF OXFORD
Research Associate in Statistical Sequence Analysis
The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN
Grade 7: £29,099 to £35,788 per annum
Applications are invited for a Research Associate in Statistical Sequence Analysis to join the group of Dr Gerton Lunter, to participate in the development of tools for identifying and genotyping genetic variants from 2nd and 3rd generation high throughput read sequencing data.
The successful applicant will develop an existing caller for genetic variants, "Platypus", to work on 3rd generation sequencing data by using a generic language to describe the statistical distribution of point and insertion/deletion errors within reads. The programme will also be extended to allow structural variation to be called off of short sequencing reads. The tool for which you will have responsibility will fit within a larger tool chain that includes read mapping, and you will work closely with the other team members to ensure that these tools work well together. Algorithmic developments will be validated through extensive experimental validation.
You will have a first degree in statistics, computer science, physics or maths and have experience with statistical modelling and inference and the research experience in the statistical analysis of human genetic variation. You will have the ability to manage the day-to-day running of a research project.
The position is available for up to three years in the first instance and is funded by BBSRC.
To apply for this role and for further details, including a job description and person specification, please click on the link below:
https://www.recruit.ox.ac.uk/pls/hrisliverecruit/erq_jobspec_version_4.jobspec?p_id=101913
Only applications received before 12:00, midday on Thursday 16th February 2012 can be considered.
You will be required to upload a CV and supporting statement as part of your online application, please quote reference 101913 in all correspondence.
Interviews will be held on the 24th and 28th February 2012.
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UNIVERSITY OF OXFORD
Senior Research Associate in Statistical Genomics (Plasmodium/Anopheles Population Genetics)
The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN
Grade 8: £36,862 to £44,016 with a discretionary range to £48,096 per annum
Applications are invited for a Senior Research Associate in Statistical Genomics (Plasmodium/Anopheles Population Genetics) for MalariaGEN, a data-sharing community working to develop new tools to control malaria by integrating epidemiology with genome science (www.malariagen.net).
You will be based in the MalariaGEN analysis team which is jointly led by Dominic Kwiatkowski, Chris Spencer and Gil McVean. You will focus on developing and implementing analytical methods in Plasmodium and Anopheles population genomics. This will involve working with the group leader to define, plan and implement one or more specific analytical projects that will make a significant contribution to MalariaGEN's scientific objectives in the area of Plasmodium and/or Anopheles population genomics. You will interact closely with other team members at the Wellcome Trust Centre for Human Genetics, and also with colleagues based at the Sanger Institute and the Mahidol-Oxford Research Unit in Bangkok, and with MalariaGEN partners around the world.
You should have a minimum of a PhD in statistics, population genetics or other relevant area of quantitative analysis and be able to execute complex analytical projects involving multiple partners. You will also have strong skills in computer programming for advanced statistical analysis and large-scale data management.
The position is available for up to three years in the first instance and is funded by The Wellcome Trust.
To apply for this role and for further details, including a job description and person specification, please click on the link below:
https://www.recruit.ox.ac.uk/pls/hrisliverecruit/erq_jobspec_version_4.jobspec?p_id=101914
Only applications received before 12:00, midday on Thursday 16th February 2012 can be considered. You will be required to upload a CV and supporting statement as part of your online application, please quote reference 101914 in all correspondence. Interviews will be held on the 24th and 28th February 2012.
Informal enquiries can be made to Professor Dominic Kwiatkowski, Director of MalariaGEN (dominic@well.ox.ac.uk).
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UNIVERSITY OF OXFORD
Senior Software Engineer in High-Throughput Sequencing
The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN
Grade 8: £36,862 to £44,016
Applications are invited for a Senior Software Engineer in High-Throughput Sequencing to join the group of Dr Gerton Lunter to develop software for mapping data from 3rd generation sequencing technologies.
You will design and develop a sequencing-error-aware short read mapper capable of handling a range of 2nd and 3rd generation sequencing data. This work will build upon an existing short-read mapper, "Stampy", which was designed to work with Illumina short-read data. The project aims to build a generic tool that will both extend the capabilities of the existing software and broaden its applicability to 3rd generation sequencing data including PacBio, IonTorrent and Nanopore platforms. This tool will fit in a larger tool-chain with variant calls as final output, and will be developed in tandem with these tools. You will be expected to take a leadership role in this project and provide day-to-day supervision to the junior team-member responsible for the implementation of the variant caller.
You will have a first degree in computer science, physics or statistics and have experience with software development on a substantial scale. You will have extensive experience with C; and experience with or ability and willingness to learn Python. You will manage the day-to-day running of a research project and have good communication skills.
The position is available for up to three years in the first instance and is funded by BBSRC.
To apply for this role and for further details, including a job description and person specification, please click on the link below:
https://www.recruit.ox.ac.uk/pls/hrisliverecruit/erq_jobspec_version_4.jobspec?p_id=101915
Only applications received before 12:00, midday on Thursday 16th February 2012 can be considered.
You will be required to upload a CV and supporting statement as part of your online application, please quote reference 101915 in all correspondence.
Interviews will be held on the 24th and 28th February 2012.
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UNIVERSITY OF OXFORD
Postdoctoral Research Scientist
The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Headington, Oxford, OX3 7BN
Grade 7: £29,099 to £35,788 with a discretionary range to £39,107 per annum
Applications are invited for a Postdoctoral Research Scientist to join Prof. Bhattacharya's Research Group at the British Heart Foundation Centre for Cardiovascular Target Discovery, located at the Wellcome Trust Centre for Human Genetics. A major goal of the British Heart Foundation Centre is to identify target genes for cardiovascular disease.
Your primary role will be to combine pooled lentiviral shRNA techniques, cellular phenotype selection based assays and next generation sequencing to identify genes controlling cellular functions relevant to cardiovascular disease. You will use suitable cell types to develop assays relevant to atherosclerotic vascular disease and deploy them in such screens. You will have a PhD in Cellular Biology, Molecular Biology or Natural Sciences and have experience in more than one of the following: mammalian cell based assays including flow cytometry, lentiviral shRNA techniques, analysis of next generation sequencing data, and mammalian cell-based genetic screens. Such screens are typically performed in cancer biology (Sims et al. Genome Biology 12, R104 (2011), and we actively encourage scientists from non-cardiovascular backgrounds, but with the necessary experience to apply.
The position is available until 31st May 2016 and is funded by the British Heart Foundation.
To apply for this role and for further details, including a job description and person specification, please click on the link below:
https://www.recruit.ox.ac.uk/pls/hrisliverecruit/erq_jobspec_version_4.jobspec?p_id=101998
Only applications received before 12:00, midday on Thursday 1st March 2012 can be considered.
You will be required to upload a CV and supporting statement as part of your online application, please quote reference 101998 in all correspondence.