Research jobs                             HR

 
 
University of Oxford
Postdoctoral Research Scientist in Immunogenomics

Wellcome Centre for Human Genetics, Roosevelt Drive, Headington, Oxford, OX3 7BN
Grade 7: £31,604 - £35,550 p.a.

Applications are invited for a Postdoctoral Research Scientist in Immunogenomics to join an established team with a track record of innovation and high impact research in the functional genomics of immunity led by Professor Julian Knight at the Wellcome Centre for Human Genetics (WHG).

We seek Postdoctoral Research Scientist in Immunogenomics with the ability to use immunological methods in the setting of a genomics programme to address challenging, cutting-edge scientific questions. You will use your skills and experience to play a key role in research to investigate the functional basis of extreme innate immune response phenotypes contributing to disease, building on our recent work in this area (Science 2014, Lancet Respiratory Medicine 2016). The goal is to advance understanding of the functional alleles driving such differences between individuals, their mechanism of action and their biological consequences in terms of gene regulation, pathophysiology and therapeutic opportunities. You will define and functionally characterise specific genes and alleles, and perform the required immune phenotyping and cellular assays. Your work will define the landscape of variable gene regulation in the extreme innate immune response within which disease associated variants act and establish mechanism.

You will hold a PhD, or in exceptional cases expected to obtain soon, in genetics, biochemistry, molecular biology or related field with a demonstrable interest in the research described here. You will have experience of immunology and molecular biology techniques. Experience of functional genomics is desirable. You will have sufficient specialist knowledge to be able to work independently, to identify major challenges and obstacles to the realisation of scientific objectives, and to set out strategies to overcome them. You will also have a strong publication record and motivation to work in a stimulating and ambitious research environment and demonstrable high level of communication skills both written and oral.

The position is funded by the Wellcome and is fixed term until 30th September 2022.

To apply for this role and for further details, including a job description and person specification, please click on the link below:

http://www.ndm.ox.ac.uk/current-job-vacancies/vacancy/131786-Postdoctoral-Research-Scientist-in-Immunogenomics

Only applications received before 12:00 midday on Monday, 27 November 2017 can be considered.

Please quote ref. 131786 on all correspondence. You will be required to upload a CV and supporting statement as part of your online application. Interviews will be held on Tuesday 5 December.

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University of Oxford
Postdoctoral Research Scientist in the Molecular Drivers of Cancer
Wellcome Centre for Human Genetics, Roosevelt Drive, Headington, Oxford, OX3 7BN
Grade 7: £31,604 - £38,833 p.a. with a discretionary range to £42,418 p.a. 

Applications are invited for a Postdoctoral Research Scientist in the Molecular Drivers of Cancer to join Dr David Church’s group at the Wellcome Centre for Human Genetics, in close collaboration with Dr David Wedge’s research group at the recently opened Big Data Institute. 

You will have extensive experience in laboratory techniques for molecular analysis and proficiency in bioinformatic analysis of next generation sequencing data. Working within the Molecular Diagnostics theme, you will explore the role of somatic cancer driver mutations in patients and their tumours, including in situ analysis. The responsibilities will be varied, but will include sample collection and preparation, experiments on cancer gene function and the analysis of genomic data from patients and their tumours.

You will have a PhD, or be near completion, in a relevant subject and the ability to work with a high degree of independence, to learn rapidly and to master several laboratory techniques. You will have experience of the genetic analysis of human diseases, including cancer and experience of other techniques of cancer analysis, specifically including western blotting and immunohistochemistry.

You will have excellent communication skills and evidence of ability to conduct and complete high quality research both independently and in collaboration as well as basic statistical proficiency and specific expertise in the analysis of next-generation sequencing data, including bioinfomatic skills in variant effect prediction and annotation. 

The position is fixed-term until 31 March 2020 in the first instance and funded by the National Institute for Health Research (NIHR) through the Oxford Biomedical Research Centre (BRC). 

To apply for this role and for further details, including a job description and person specification, please click on the link below:

http://www.ndm.ox.ac.uk/current-job-vacancies/vacancy/131838-Postdoctoral-Research-Scientist-in-the-Molecular-Drivers-of-Cancer

Only applications received before 12.00 midday on Monday 27th November 2017 can be considered. Please quote reference 131838 on all correspondence. You will be required to upload a CV and supporting statement as part of your online application.

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University of Oxford
Statistical Programmer (Two posts), JDRF/Wellcome Diabetes and Inflamation Laboratory (DIL) in data analysis and integration
Wellcome Centre for Human Genetics, Roosevelt Drive, Headington, Oxford, OX3 7BN
Grade 8: £39,992 - £47,722 with a discretionary range to £52,132 p.a. Depending on experience, this post may be offered at Grade 7: £31,604 - £38,833 p.a. with reduced responsibilities. 

We have two exciting Statistical Programmer posts available at the JDRF/Wellcome Diabetes and Inflammation Laboratory (DIL) in data analysis and integration.

The DIL aims to treat and prevent the autoimmune disease type 1 diabetes by understanding the underlying genetic and mechanistic pathways. From our own projects and others worldwide (e.g. http://helmsleytrust.org/news/helmsley-charitable-trust-awards-52-million-support-global-platform-prevention-autoimmune) there is a data avalanche that will accelerate our understanding of autoimmunity, affecting over 5% of populations, with an aim to prevent and develop treatments for type 1 diabetes.

You will lead research projects and support statistical analyses throughout the DIL, help supervise junior group members and DPhil students, contribute to writing grant applications and join our collaborations, nationally and internationally, at a senior level.

You will be passionate about statistics, experimental design and analysis, and about wanting to make a difference in a major childhood illness. Excellent communication skills and a proven, successful track record in biomedical research are essential.

You will have a first degree in a relevant subject area such as computer science, bioinformatics, mathematics, biostatistics, medical statistics or statistics along with substantial experience and a strong track record of applying statistics and programming in a scientific environment. You will be an expert in one or more programming languages, such as bash, R, C, Python. A PhD in a relevant subject area would be desirable.

The posts are funded by the Wellcome and are fixed term until 30 September 2020 in the first instance.

Applications for this vacancy are to be made online. You will be required to upload a CV and supporting statement as part of your online application.

To apply for this role and for further details, including a job description and person specification, please click on the link below:

http://www.ndm.ox.ac.uk/current-job-vacancies/vacancy/131660-Statistical-Programmer-in-data-analysis-and-integration-for-Diabetes-and-Inflammation-Laboratory   

Informal inquiries can be made to Prof John Todd, Director of the DIL (john.todd@well.ox.ac.uk) or Dr Olga Platonova, Programme Administrator (olga@well.ox.ac.uk).

Only applications received before 12.00, midday on Thursday 21 December 2017 can be considered. Please quote reference 131660 on all correspondence.

Shortlisting will be completed by 12 January 2018 and interviews will be held on 18 and 19 January 2018.

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University of Oxford
Postdoctoral Research Scientist in Structural Biology
Division of Structural Biology, Wellcome Centre for Human Genetics, Research Complex at Harwell, Didcot, Oxfordshire OX11 0FA
Grade 7: £31,604 - £38,833 with a discretionary range to £42,418 p.a. 

Applications are invited for a Postdoctoral Research Scientist in Structural Biology to join a European Research Council funded project in Professor James Naismith’s group based in the Research Complex at Harwell.

You will manage your own academic research activities, involving small scale project management to co-ordinate multiple aspects of work and meet deadlines. You will adapt existing and develop new scientific techniques and experimental protocols and test hypotheses and analyse scientific data from a variety of sources, reviewing and refining working hypotheses as appropriate. You will contribute ideas for new research projects and present scientific results through journal articles, posters and presentations at national/international conferences. You will use specialist scientific equipment in a laboratory environment and will act as a source of information and advice to other group members. You will carry out collaborative projects with partner institutions.

You should be highly motivated and have a PhD in structural biology, biochemistry, protein lipid chemistry or a related field and research experience in at least one of the following areas: production of proteins; sophisticated assays; peptide synthesis. You should have experience with Biophysics with demonstrated ability to report results in peer reviewed journal. You will have the ability to manage the day-to-day running of a research project, working as part of a team and show the ability to organise and prioritse your own work with minimal supervision. You will have excellent communication skills.

The position is fixed term for 1 year in the first instance and is funded by the European Research Council.

Applications for this vacancy are to be made online. You will be required to upload a CV and supporting statement as part of your online application.

To apply for this role and for further details, including a job description and person specification, please click on the link below:

http://www.ndm.ox.ac.uk/current-job-vacancies/vacancy/131839-Postdoctoral-Research-Scientist-in-Structural-Biology  

Only applications received before 12:00 midday on Wednesday 3 January 2018 can be considered. Please quote reference 131839 on all correspondence.

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University of Oxford
Postdoctoral Research Scientist in Structural Biology
Division of Structural Biology, Wellcome Centre for Human Genetics, Research Complex at Harwell, Didcot, Oxfordshire OX11 0FA
Grade 7: £31,604 - £38,833 with a discretionary range to £42,418 p.a. 

Applications are invited for a Postdoctoral Research Scientist in Structural Biology to join a Wellcome funded project in Professor James Naismith’s group based in the Research Complex at Harwell.

You will manage your own academic research activities, involving small scale project management to co-ordinate multiple aspects of work and meet deadlines. You will adapt existing and develop new scientific techniques and experimental protocols and test hypotheses and analyse scientific data from a variety of sources, reviewing and refining working hypotheses as appropriate. You will contribute ideas for new research projects and present scientific results through journal articles, posters and presentations at national/international conferences. You will use specialist scientific equipment in a laboratory environment and will act as a source of information and advice to other group members. You will carry out collaborative projects with partner institutions.

You should be highly motivated and have a PhD in structural biology, biochemistry, protein lipid chemistry or a related field and research experience in at least one of the following areas: production of membrane protein; crystallization and X-ray crystallography; single-particle cryo-electron microscopy. You should have experience with Biophysics with demonstrated ability to report results in peer reviewed journal. You will have the ability to manage the day-to-day running of a research project, working as part of a team and show the ability to organise and prioritse your own work with minimal supervision. You will have excellent communication skills.

The position is fixed term for 2 years in the first instance and funded by the Wellcome.

Applications for this vacancy are to be made online. You will be required to upload a CV and supporting statement as part of your online application.

To apply for this role and for further details, including a job description and person specification, please click on the link below:

http://www.ndm.ox.ac.uk/current-job-vacancies/vacancy/131840-Postdoctoral-Research-Scientist-in-Structural-Biology   

Only applications received before 12:00 midday on Wednesday 3 January 2018 can be considered. Please quote ref. 131840 on all correspondence.

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