The Centre is composed of scientific research groups that work to understand the genetic foundations of human variation and disease. Scientists in the Centre work in diverse fields, developing and applying statistical, computational, and experimental methods to a wide range of medical conditions. The main areas of research include bioinformatics, cardiovascular disease, genomics, structural biology, immunity and inflammation, cancer genetics, metabolism, neurogenetics, statistical genetics and transgenics.
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Prof. Jonathan Flint: Anxiety and depression |
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Prof. Richard Mott: Bioinformatics applications, mouse genetics and statistical bioinformatics |
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Prof. Anthony Monaco: Neurodevelopmental genetics (autism and dyslexia) |
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Dr Dianne Newbury: Speech and language impairments |
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Prof. Adrian Hill: Vaccine development against malaria and other pathogens; genetics susceptibility to bacterial and other infectious diseases |
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Prof. Dominic Kwiatkowski: Host determinants of malarial pathogenesis |
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Dr Julian Knight: Functional genomics of immunity |
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Prof. Shoumo Bhattacharya: Cardiac development, congenital heart disease and myocardial homeostasis |
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Prof. Barbara Casadei: Nitric oxide/redox signalling in health and disease (e.g., myocardial ischaemia, diabetes, heart failure and atrial fibrillation) |
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Prof. Keith Channon: The role of nitric oxide and superoxide in the early endothelial dysfunction characteristic of pre-atherosclerotic states |
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Prof. Stefan Neubauer: The role of cardiac energetics in heart failure and magnetic resonance techniques for phenotyping cardiovascular disease |
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Prof. Hugh Watkins: Molecular genetics and molecular biology of heart muscle disease; molecular genetics of complex cardiovascular phenotypes |
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Dr Robin Choudhury: Development and application of magnetic resonance imaging to characterise atherosclerosis and vascular disease |
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Prof. Martin Farrall: The molecular basis and population genetics of multifactorial cardiovascular disease and associated quantitative (intermediate) phenotypes |
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Dr Jurgen Schneider: Development of fast cardiac MRI techniques at ultra-high fields |
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Prof. Mark McCarthy: Human Type 2 diabetes and obesity |
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Dr Cecilia Lindgren: Genetics and genomics of obesity |
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Prof. Peter Donnelly: Genome-wide association methods; statistical genetics; genomic epidemiology; genomics |
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Prof. Chris Holmes: Theory, methods and applications of statistical models in the fields of statistical genetics and geo-spatial statistics |
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Dr Gerton Lunter: Genome evolution; indel mutations |
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Prof. Gil McVean: Population genetics; coalescent modelling; statistical genetics; pathogen evolution and variation |
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Dr Jonathan Marchini: Statistical genetics; genome-wide association studies; computationally intensive statistics; Bayesian statistics; image analysis |
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Dr Andrew Morris: Genomic epidemiology; statistical genetics |
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Dr Simon Myers: Population genetics, specifically the use of stochastic models to understand patterns of variation in samples drawn from a population  |
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Dr Chris Spencer: Statistical and population genetics; in particular autoimmune and infectious disease with a focus on African populations. |
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Dr Krina Zondervan: Genomic epidemiology |
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Prof. Yvonne Jones: Cell-cell communication and signalling systems in developmental biology |
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Prof. Dave Stuart: Viruses, viral proteins and cell surface receptors |
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Dr Radu Aricescu: The structural biology of memory |
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Dr Robert Gilbert: Structural biology of membrane proteins, viruses and ribosomes |
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Dr Jonathan Grimes: Structural virology |
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Prof Kay Grünewald: Cryo electron tomographic studies of complex viruses |
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Dr Juha Huiskonen: Structures of haemorrhagic viruses |
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Dr Erika Mancini: Helicases and ATP-driven nucleic acid motors |
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Dr Ray Owens: Oxford Protein Production Facility |
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Dr Christian Siebold: Molecular mechanisms of hedgehog signalling |
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Dr Sergi Padilla-Parra: Regulation of virus entry mechanisms, and core cellular imaging |
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Prof. Ian Tomlinson: Cancer genetics, population genetics, roles of selection and genomic instability in tumorigenesis, gastrointestinal cancer, renal cancer, mouse models, mitochondrial tumour suppressor genes |
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Dr Simon Leedham: Molecular and Population Genetics |
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Dr Ross Chapman: Chromatin and genome integrity |
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Dr David Buck: Head of Core Genomics |
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Chromosome Dynamics |
Transgenics | ||
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Dr Catherine Green: Chromosome stability during DNA replication, and core cytogenetics support for other groups |
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Dr Ben Davies: Transgenic methodologies and adapting existing technologies to tackle the functional analysis of genetic variation |
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Dr Jenny Taylor: Translation of genetics research into clinical practice |
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Dr Samantha Knight: Translational genetics: bringing clinically relevant research into routine diagnostic practice. |
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