Research groups at WTCHG

The Centre is composed of scientific research groups that work to understand the genetic foundations of human variation and disease. Scientists in the Centre work in diverse fields, developing and applying statistical, computational, and experimental methods to a wide range of medical conditions. The main areas of research include bioinformatics, cardiovascular disease, genomics, structural biology, immunity and inflammation, cancer genetics, metabolism, neurogenetics, statistical genetics and transgenics.

 

Neurogenetics and Psychiatric Genetics 

TonyMonaco

Prof. Anthony Monaco: Neurodevelopmental genetics (autism and dyslexia)

   

Immunity, Inflammation and Infectious Disease

AdrianHill

Prof. Adrian Hill: Vaccine development against malaria and other pathogens; genetics susceptibility to bacterial and other infectious diseases

D Kwaitkowski

Prof. Dominic Kwiatkowski: Host determinants of malarial pathogenesis

JulianKnight

Prof. Julian Knight: Functional genomics of immunity

john-todd-thumb

Prof. John Todd: JDRF/Wellcome Trust Diabetes and Inflammation Laboratory (DIL)

Cardiovascular Disease

Shoumo Bhattacharya

Prof. Shoumo Bhattacharya: Cardiac development, congenital heart disease and myocardial homeostasis

Barbara Casadei

Prof. Barbara Casadei: Nitric oxide/redox signalling in health and disease (e.g. myocardial ischaemia, diabetes, heart failure and atrial fibrillation)

Keith Channon

Prof. Keith Channon: The role of nitric oxide and superoxide in the early endothelial dysfunction characteristic of pre-atherosclerotic states

Robin Choudhury

Prof. Robin Choudhury: Development and application of magnetic resonance imaging to characterise atherosclerosis and vascular disease

MartinFarrall

Prof. Martin Farrall: The molecular basis and population genetics of multifactorial cardiovascular disease and associated quantitative (intermediate) phenotypes. Visit the PROCARDIS webpages

StefanNeubauer

Prof. Stefan Neubauer: The role of cardiac energetics in heart failure and magnetic resonance techniques for phenotyping cardiovascular disease

Ellie Tzima

Prof. Ellie Tzima: Cardiovascular Science and Molecular, Cell & Systems Biology

 

JurgenSchneider

Prof. Jurgen Schneider: Development of fast cardiac MRI techniques at ultra-high fields

Hugh Watkins

Prof. Hugh Watkins: Molecular genetics and molecular biology of heart muscle disease; molecular genetics of complex cardiovascular phenotypes. Visit the PROCARDIS webpages

   

Genetics of Type 2 Diabetes

Anna Gloyn

Prof. Anna GloynHuman Type 2 diabetes and glycaemic traits

C Lindgren

Prof. Cecilia LindgrenGenetics and genomics of obesity

Mark McCarthy

Prof. Mark McCarthyHuman Type 2 diabetes and obesity

Statistical and Population Genetics

Peter Donnelly

Prof. Peter Donnelly: Genome-wide association methods; statistical genetics; genomic epidemiology; genomics

C Holmes

Prof. Chris Holmes: Theory, methods and applications of statistical models in the fields of statistical genetics and geo-spatial statistics

Zam Iqbal

Dr Zamin Iqbal: Computational methods, pathogen genomics

Gerton Lunter

Prof. Gerton Lunter: Genome evolution; indel mutations

GilMcVean

Prof. Gil McVean: Population genetics; coalescent modelling; statistical genetics; pathogen evolution and variation

J Marchini

Prof. Jonathan Marchini: Statistical genetics; genome-wide association studies; computationally intensive statistics; Bayesian statistics; image analysis

A Morris

Dr Andrew Morris: Genomic epidemiology; statistical genetics

S Myers

Prof. Simon Myers: Population genetics, specifically the use of stochastic models to understand patterns of variation in samples drawn from a population

Chris Spencer

Dr Chris Spencer: Statistical and population genetics; in particular autoimmune and infectious disease with a focus on African populations

Christopher Yau

Prof. Chris Yau: Computational statistical methods for applications in cancer genetics and genomics

Krina Zondervan
Prof. Krina Zondervan: Genomic epidemiology, Endometriosis, Women's Health

Structural Biology

YvonneJones

Prof. Yvonne Jones: Cell-cell communication and signalling systems in developmental biology

Dave Stuart

Prof. Dave Stuart: Viruses, viral proteins and cell surface receptors

RaduAricescu

Prof. Radu Aricescu: The structural biology of memory

Thomas Bowden

Dr Thomas Bowden: Viral attachment glycoproteins during infection

RobertGilbert

Prof. Robert Gilbert: Structural biology of membrane proteins, viruses and ribosomes

JonGrimes

Prof. Jonathan Grimes: Structural virology

KayGrunewald

Prof Kay Grünewald: Cryo electron tomographic studies of complex viruses

JuhaHuiskonen

Prof. Juha Huiskonen: Structures of haemorrhagic viruses

ray owens

Prof. Ray Owens: Oxford Protein Production Facility

ChristianSiebold

Prof. Christian Siebold: Molecular mechanisms of hedgehog signalling

sergipadilla

Dr Sergi Padilla-Parra: Regulation of virus entry mechanisms, and core cellular imaging

Tzviya Zeev-Ben-Mordehai

Dr Tzviya Zeev-Ben-Mordehai: Mechanisms of membrane fusion

Cancer Genetics

IanTomlinson

Prof. Ian Tomlinson: Cancer genetics, population genetics, roles of selection and genomic instability in tumorigenesis, gastrointestinal cancer, renal cancer, mouse models, mitochondrial tumour suppressor genes

SimonLeedham

Prof. Simon Leedham: Molecular and Population Genetics

Ross Chapman

Dr Ross ChapmanChromatin and genome integrity

David Church

Dr David Church: Tumor and host interactions

Genomics

DavidBuck

Dr David Buck: Head of Core Genomics

 

 

Chromosome Dynamics

Transgenics

CathGREENphoto_1

Prof. Catherine Green: Chromosome stability during DNA replication, and core cytogenetics support for other groups

BenDavies Dr Ben Davies: Transgenic methodologies and adapting existing technologies to tackle the functional analysis of genetic variation

Translational Genetics

J Taylor

Prof. Jenny Taylor: Translation of genetics research into clinical practice

SamKnight

Dr Samantha Knight: Translational genetics: bringing clinically relevant research into routine diagnostic practice