The Centre's scientific objectives are:
To these ends, it conducts research in the following areas:
The Centre's research encompasses both infectious and non-communicable diseases, affecting both the developing world as well as industrialised countries.
The Structural Biology Division (STRUBI) aims to integrate analyses ranging from the atomic-level precision of X-ray crystallography through cryo-electron microscopy and tomography, the the cellular-level details revealed by fluorescent light microscopy and X-ray microscopy. The research interests of all group leaders are increasingly focused on defining the mechanisms of action of large macromolecular assemblies with the cellular context.
Much of modern biomedical research involves collecting and analysing large-scale data sets on biological variation. The Statistical and Population Genetics programme aims to use statistical analysis and mathematical modelling to describe and understand patterns of biological variation. Group members have played key roles in major international initiatives including the Wellcome Trust Case Control Consortia (WTCCC, WTCCC2), the 1000 Genomes Project and the International HapMap Project. (Peter Donnelly, Chris Holmes, Zamin Iqbal, Gerton Lunter, Gil McVean, Jonathan Marchini, Andrew Morris, Simon Myers, Chris Spencer, Christopher Yau)
Much of the translational work in the Centre is coordinated by the Genomic Medicine Theme of the Oxford Biomedical Research Centre (a partnership between the University of Oxford and Oxford University Hospitals). Its aim is to translate research findings in genetics into clinical practice for a range of clinically-important conditions, and to develop advanced technologies for use in the NHS and healthcare services globally. (Jenny Taylor, Samantha Knight)
The High Throughput Genomics Core at the Centre collaborates with researchers in many fields to develop applications of high throughput sequencing as a route to understanding human disease. (David Buck)
The focus of the transgenics group is to increase the efficiency and reliability of the genetic manipulation and to develop novel transgenic methodologies focused on providing in vivo analysis tools for the study of genetic variation and mutation. (Ben Davies)