HR

Research Positions

 

 

 

 

UNIVERSITY OF OXFORD                                                                                                 POSTDOCTORAL RESEARCH SCIENTIST IN GENOME STABILITY                                      WELLCOME TRUST CENTRE FOR HUMAN GENETICS, ROOSEVELT DRIVE, HEADINGTON, OXFORD, OX3 7BN                                                                                                                    Grade 7: £30,434 - £31,342p.a.

Applications are invited for a Postdoctoral Research Scientist in Genome Stability to join the Chromatin & Genome Integrity group headed by Dr Ross Chapman. Their research aims to understand how DNA double-strand breaks (DSBs) are detected, signalled and repaired in mammalian cells, and why inappropriate DSB repair regulation underlies the pathology of common human cancers and primary immunodeficiency disorders.

You will research a newly identified chromatin factor with a central role in inhibiting nucleolytic DNA end-resection during DNA repair. Combining transgenics and established immunological and cellular systems to model DSB repair events in both physiological and pathological contexts, you will define the molecular mechanisms by which this factor regulates chromatin states at break sites to coordinate DNA repair outcomes.

You will have a relevant PhD and research expertise in the fields of genome stability, chromatin biology, or cellular immunology. You will also have demonstrable expertise in molecular biology, in mammalian tissue culture, protein interaction studies and general biochemical and cell-biology techniques. You will also have a good publication record relative to career stage, ideally with at least two first or second author articles in leading refereed journals and presentations of papers at international conferences, or equivalent. Working as part of a team, you will manage the day-to-day running of a research project including assisting the work of junior researchers and research assistants, and managing resources effectively.

The position is funded by the Medical Research Council and is fixed term for 3 years in the first instance.

To apply for this role and for further details, including a job description and a person specification, please click on the link below:

https://www.recruit.ox.ac.uk/pls/hrisliverecruit/erq_jobspec_version_4.jobspec?p_id=116792

Only applications received before 12:00 midday on Wednesday 18th February 2015 will be considered.

Please quote ref. 116792 on all correspondence. You will be required to upload a CV and supporting statement as part of your online application.

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UNIVERSITY OF OXFORD                                                                                                     RESEARCH SCIENTIST AND PROJECT MANAGER IN GENOMICS OF IMMUNITY                     WELLCOME TRUST CENTRE FOR HUMAN GENETICS, ROOSEVELT DRIVE, HEADINGTON, OXFORD, OX3 7BN                                                                                                                   Grade 7: Salary in the range £30,434 - £34,233 p.a.

Applications are invited for the position of Research Scientist and Project Manager in Genomics of Immunity. You will join an exciting new research programme to understand pathogenesis and improve treatment of patients with ankylosing spondylitis (AS) using an integrated functional immunogenomics approach. This research will build on recent success in genome-wide association studies of AS to now fine-map associations and establish function for disease associated genetic variants in a disease context, defining mechanistic links with particular gene(s) and pathways that can be taken forward as potential drug targets.

We are seeking an exceptional individual, who is motivated to excel in both wet lab genomic research at the bench and in facilitating project delivery. You will have a PhD in genetics, biochemistry, molecular biology or a related field, or evidence of substantial relevant expertise and laboratory management experience. This is an opportunity to perform outstanding genomics research in a world-leading institute and develop your management and people skills, building on your track record of scientific excellence, outstanding communication skills, experience of supervision, effective team working and relevant laboratory experience.

The position is funded by Arthritis Research UK and is fixed term for 5 years.

To apply for this role and for further details, including a job description and a person specification, please click on the link below:

https://www.recruit.ox.ac.uk/pls/hrisliverecruit/erq_jobspec_version_4.jobspec?p_id=116888

Only applications received before 12:00 midday on Friday 27th February 2015 will be considered.

Please quote ref. 116888 on all correspondence. You will be required to upload a CV and supporting statement as part of your online application.

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