HR

Research

 

 

 

 

UNIVERSITY OF OXFORD
RESEARCH ASSISTANT IN VIRAL GENOMICS
WELLCOME TRUST CENTRE FOR HUMAN GENETICS (MOVING TO BIG DATA INSTITUTE UPON COMPLETION IN EARLY 2017) ROOSEVELT DRIVE, HEADINGTON, OXFORD, OX3 7BN / PETER MEDAWAR BUILDING

Grade 6: £29,629 to £32,958 per annum

This is an exciting opportunity to join the new Oxford Big Data Institute (BDI), based at the University of Oxford. Research at the BDI will be focussed on analysis of biomedical big data, and generation of health knowledge and information. You will be a Research Assistant in Viral Genomics, reporting to Professor Christophe Fraser in the Pathogen Dynamics group in the Big Data Institute.

We aim to recruit a motivated individual to develop and run a high-throughput system for biological-sample handling. As a laboratory technician you will be responsible for the extraction of high-quality nucleic acids and the early phases of preparing DNA sequencing libraries for downstream viral genotyping of HIV-1 as part of a series of some very large phylogenetic studies of HIV/AIDS in Africa and Europe. Working within a laboratory team across two sites, the Peter Medawar Building for Pathogen Research and the Wellcome Trust Centre for Human Genetics, you will extract viral RNA from frozen infected plasma and prepare the cDNA for downstream sequencing. Under supervision, you will develop systems of sample QC that will maintain high-standards of sample preparation and assist in quantitative normalization and batching of samples for downstream sequencing. You will receive training to operate and maintain an automated system for assaying HIV-1 viral load.

You will take an experimental approach to the development of high-throughput standard operating protocols (SOPS) that you will use, monitor and optimize to achieve high levels of assay sensitivity and sample quality. You will audit and report on your progress and contribute to the publications of the methods you help to develop.

You will hold a first degree in a field relevant to the biological sciences, ideally incorporating the biomedical sciences and/or molecular biology, have the ability to write up experimental results. You will have experience of working in a laboratory environment and knowledge of relevant health and safety regulations.

The position is fixed-term until 30 November 2018 and is funded by the NIH.

To apply for this role and for further details, including a job description and a person specification, please click on the link below:

https://www.recruit.ox.ac.uk/pls/hrisliverecruit/erq_jobspec_version_4.jobspec?p_id=128270

Only applications received before 12:00 midday on Monday 3 April 2017 can be considered.

Please quote reference 128270 on all correspondence. You will be required to upload a CV and supporting statement as part of your online application.

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UNIVERSITY OF OXFORD
SENIOR RESEARCHER IN PATHOGEN PHYLODYNAMICS

WELLCOME TRUST CENTRE FOR HUMAN GENETICS (MOVING TO BIG DATA INSTITUTE UPON COMPLETION IN EARLY 2017) ROOSEVELT DRIVE, HEADINGTON, OXFORD, OX3 7BN
Grade 9: £45,562 - £52,793 with a discretionary range to £57,674 p.a.

Applications are invited for a Senior Researcher in Pathogen Phylodynamicsto to work within the group at the Big Data Institute, currently located at Wellcome Trust Centre for Human Genetics, led by Professor Christophe Fraser.

Together with Professor Fraser, you will develop and co-lead a program of research in phylodynamics of pathogens, that is, the science at the intersection of pathogen genetics and epidemiology. You will push forwards the boundaries of methods development in this highly technical field, and will prioritise applications of phylodynamics that generate actionable knowledge in public health.

Areas of particular interest are the phylodynamics of HIV, and of antimicrobial resistant pathogens. You will be expected to engage with several major projects focussed on using HIV genomes to better characterise the HIV epidemic, including the PANGEA-HIV consortium, the HPTN 071 (PopART) trial, and the BEEHIVE project – all of which have Oxford BDI as a major hub. You will prioritise cross-ranging methodological contributions that will accelerate research across these projects, and contribute to training and co-supervision of new staff joining these projects.  

You will hold a Ph.D/D.Phil in a relevant discipline, such as biology (quantitative), microbiology, physics, computer science, and statistics and have significant post-doctoral research experience.  You will possess sufficient specialist knowledge in phylodynamics to develop and communicate innovative research programmes and methodologies, and a growing, internationally recognised reputation in the area of mathematical modelling of public health interventions. You will have a strong publication record and possess a track record of successful grant or fellowship applications.

The position is fixed-term for five years in the first instance and funded by the Li Ka Shing Fellowship.

To apply for this role and for further details, including a job description and a person specification, please click on the link below:

http://www.ndm.ox.ac.uk/current-job-vacancies/vacancy/127843-Senior-Researcher-in-Pathogen-Phylodynamics

Only applications received before 12:00 midday on Wednesday 5 April 2017 can be considered.

Please quote reference 127843 on all correspondence. You will be required to upload a CV and supporting statement as part of your online application.

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UNIVERSITY OF OXFORD
POSTDOCTORAL RESEARCHER IN SINGLE-CELL TRANSCRIPTOMICS
WELLCOME TRUST CENTRE FOR HUMAN GENETICS, ROOSEVELT DRIVE, HEADINGTON, OXFORD, OX3 7BN

Grade 7: £31,076 - £38,183 p.a. (with a discretionary range to £41,709p.a.)                                                                                                                                                              

Applications are invited for Postdoctoral Researcher in Single-Cell Transcriptomics as part of a Wellcome Trust and Royal Society-funded research programme led by Dr Calli Dendrou at the Wellcome Trust Centre for Human Genetics.

You will be involved in a unique research programme investigating molecular circuits implicated across multiple autoimmune diseases, and in assessing how these circuits may be perturbed by both genetic and environmental factors. You will perform single-cell RNA-seq experiments using primary human immune cells but may also have the opportunity to use other genomics methods and/or carry out protein level analyses as well, including mass cytometry.

You will have a PhD in molecular immunology, molecular biology, biotechnology or related discipline with prior wet lab experience performing single-cell RNA-seq (e.g. RNA-seq library preparation and next generation sequencing). You will have prior experience analysing single-cell RNA-seq data; experience in basic molecular biology and/or cell culture techniques; research experience investigating immunological or genetic pathophysiological mechanisms underlying
immune-mediated diseases and experience working with human samples. You will also have excellent communication skills as demonstrated by both oral presentation skills and a strong publication record (one or more first author publications in peer-reviewed journals)

The position is fixed term for three years and funded by Sir Henry Dale Fellowship.

To apply for this role and for further details, including a job description and person specification, please click on the link below:

http://www.ndm.ox.ac.uk/current-job-vacancies/vacancy/128115-Postdoctoral-Researcher-in-Single---Cell-Transcriptomics

Only applications received before 12:00 midday on Wednesday 26th April 2017 can be considered.

Please quote ref. 128115 on all correspondence. You will be required to upload a CV and supporting statement as part of your online application.

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UNIVERSITY OF OXFORD
POSTDOCTORAL RESEARCH SCIENTIST IN TRANSGENIC TECHNOLOGIES

WELLCOME TRUST CENTRE FOR HUMAN GENETICS, ROOSEVELT DRIVE, HEADINGTON, OXFORD, OX3 7BN
Grade 7: £31,076 - £38,183 p.a. (with a discretionary range to £41,255p.a.)

Applications are invited for an enthusiastic Postdoctoral Research Scientist in Transgenic Technologies to help in the day-to-day management of the centre’s transgenic core research group at the Wellcome Trust Centre for Human Genetics.

You will contribute to the all areas of the core and the research activities of the group by providing project management and scientific support in the areas of molecular biology, cell culture, mouse embryo microinjection, assisted husbandry techniques and cryopreservation. We seek an individual with proven expertise in transgenic technologies and experience in project management who will contribute to the success of the core through supervision of core staff, troubleshooting, hands-on laboratory work and management of projects.

You should have a PhD in molecular biology, biochemistry, genetics, a related discipline or expectation that your thesis will be submitted before June 2017. You should also have expertise in, and detailed knowledge of at least two of the following key transgenic techniques: mammalian embryo microinjection; gene targeting / genome editing; assisted Reproduction e.g. IVF, embryo transfer as well as proven experience in scientific project management. We anticipate the role to be exceptionally diverse and would suit an individual with a proven track record in work with transgenic models who is enthusiastic and motivated to move to a service oriented role within a core facility. Although service would be the predominant task, there remains considerable flexibility and scope for independent research into genome engineering methodologies.

The position is fixed-term for three years in the first instance and funded by the Department.

To apply for this role and for further details, including a job description and person specification, please click on the link below:

http://www.ndm.ox.ac.uk/current-job-vacancies/vacancy/128069-Postdoctoral-Research-Scientist-in-Transgenic-Technologies

Only applications received before 12.00 midday on Wednesday 26 April 2017 can be considered. Please quote reference 128069 on all correspondence. You will be required to upload a CV and supporting statement as part of your online application.

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