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University of Oxford
Postdoctoral Research Scientist in Genetics

Wellcome Centre for Human Genetics, Roosevelt Drive, Headington, Oxford, OX3 7BN
Grade 7: £31,604 - £38,833 p.a. (with a discretionary range to £42,418p.a.) 

Applications are invited for a Postdoctoral Research Scientist in Genetics to join Professor Adrian Hill’s group at the Wellcome Centre for Human Genetics.

This work aims to understand how variation in human genetic architecture shapes the responses to vaccines and infectious agents across populations in order to facilitate discoveries that can be translated into effective preventative strategies such as improved vaccination.

You will be motivated scientist who strives to produce work of the highest quality and who is keen to support the international development of capacity for genetics and genomics. The research work will involve using bioinformatic tools including genome-wide association analyses in structured populations to identify genetic signals that impact on the host immune system and the ability to respond to infectious agents. It is likely that the post will involve periods of overseas travel to support ongoing initiatives developing capacity for genetics and genomics in low-to-middle income countries such as Mexico.

You will have a PhD/DPhil (or be in the process of completing) with appropriate research experience; strong publication record and familiarity with the existing literature and research in human genetics, immunology and infectious disease; significant experience in human bioinformatics and proficient in statistical programming using R or equivalent. You will work effectively within an international team of scientists, manage your work-time efficiently and deliver high quality results to a required standard schedule. Previous laboratory experience, computer skills, good communication skills and the ability to work as part of a team are essential.

This position is fixed-term until 13th April 2019 in the first instance and funded by the Research Councils UK.

To apply for this role and for further details, including a job description and a person specification, please click on the link below:

http://www.ndm.ox.ac.uk/current-job-vacancies/vacancy/131497-Postdoctoral-Research-Scientist-in-Genetics

Only applications received before 12.00 midday, on Wednesday 22 November 2017 can be considered. Please quote ref. 131497 on all correspondence. You will be required to upload a CV and supporting statement as part of your online application.

 

 

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University of Oxford
Postdoctoral Research Scientist in Immunogenomics

Wellcome Centre for Human Genetics, Roosevelt Drive, Headington, Oxford, OX3 7BN
Grade 7: Salary in range £31,604 to £35,550 p.a.

Applications are invited for a Postdoctoral Research Scientist in Immunogenomics to join an established team with a track record of innovation and high impact research in the functional genomics of immunity led by Professor Julian Knight at the Wellcome Centre for Human Genetics (WHG).

We seek Postdoctoral Research Scientist in Immunogenomics with the ability to use immunological methods in the setting of a genomics programme to address challenging, cutting-edge scientific questions. You will use your skills and experience to play a key role in research to investigate the functional basis of extreme innate immune response phenotypes contributing to disease, building on our recent work in this area (Science 2014, Lancet Respiratory Medicine 2016). The goal is to advance understanding of the functional alleles driving such differences between individuals, their mechanism of action and their biological consequences in terms of gene regulation, pathophysiology and therapeutic opportunities. You will define and functionally characterise specific genes and alleles, and perform the required immune phenotyping and cellular assays. Your work will define the landscape of variable gene regulation in the extreme innate immune response within which disease associated variants act and establish mechanism.

You will hold a PhD, or in exceptional cases expected to obtain soon, in genetics, biochemistry, molecular biology or related field with a demonstrable interest in the research described here. You will have experience of immunology and molecular biology techniques. Experience of functional genomics is desirable. You will have sufficient specialist knowledge to be able to work independently, to identify major challenges and obstacles to the realisation of scientific objectives, and to set out strategies to overcome them. You will also have a strong publication record and motivation to work in a stimulating and ambitious research environment and demonstrable high level of communication skills both written and oral.

The position is funded by the Wellcome and is fixed term until 30th September 2022.

To apply for this role and for further details, including a job description and person specification, please click on the link below:

http://www.ndm.ox.ac.uk/current-job-vacancies/vacancy/131786-Postdoctoral-Research-Scientist-in-Immunogenomics

Only applications received before 12:00 midday on Monday, 27 November 2017 can be considered.

Please quote ref. 131786 on all correspondence. You will be required to upload a CV and supporting statement as part of your online application. Interviews will be held on Tuesday 5 December.

 

 

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University of Oxford
Postdoctoral Research Scientist in the Molecular Drivers of Cancer
Wellcome Centre for Human Genetics, Roosevelt Drive, Headington, Oxford, OX3 7BN
Grade 7: £31,604 - £38,833 p.a. (with a discretionary range to £42,418p.a.) 

Applications are invited for a Postdoctoral Research Scientist in the Molecular Drivers of Cancer to join Dr David Church’s group at the Wellcome Centre for Human Genetics, in close collaboration with Dr David Wedge’s research group at the recently opened Big Data Institute. 

You will have extensive experience in laboratory techniques for molecular analysis and proficiency in bioinformatic analysis of next generation sequencing data. Working within the Molecular Diagnostics theme, you will explore the role of somatic cancer driver mutations in patients and their tumours, including in situ analysis. The responsibilities will be varied, but will include sample collection and preparation, experiments on cancer gene function and the analysis of genomic data from patients and their tumours.

You will have a PhD, or be near completion, in a relevant subject and the ability to work with a high degree of independence, to learn rapidly and to master several laboratory techniques. You will have experience of the genetic analysis of human diseases, including cancer and experience of other techniques of cancer analysis, specifically including western blotting and immunohistochemistry.

You will have excellent communication skills and evidence of ability to conduct and complete high quality research both independently and in collaboration as well as basic statistical proficiency and specific expertise in the analysis of next-generation sequencing data, including bioinfomatic skills in variant effect prediction and annotation. 

The position is fixed-term until 31 March 2020 in the first instance and funded by the National Institute for Health Research (NIHR) through the Oxford Biomedical Research Centre (BRC). 

To apply for this role and for further details, including a job description and person specification, please click on the link below:

http://www.ndm.ox.ac.uk/current-job-vacancies/vacancy/131838-Postdoctoral-Research-Scientist-in-the-Molecular-Drivers-of-Cancer

Only applications received before 12.00 midday on Monday 27th November 2017 can be considered. Please quote reference 131838 on all correspondence. You will be required to upload a CV and supporting statement as part of your online application.