HR

Research

 

 

 

UNIVERSITY OF OXFORD
POSTDOCTORAL RESEARCH FELLOW IN MOLECULAR GENETICS OF CANCER
WELLCOME TRUST CENTRE FOR HUMAN GENETICS, ROOSEVELT DRIVE, HEADINGTON, OXFORD, OX3 7BN 
Grade 7: Salary in the range £31,076 - £34,956 p.a.

Applications are invited for a Postdoctoral Research Fellow in the Molecular Genetics of Cancer to join Professor Ian Tomlinson group. The group’s main interests are susceptibility to cancer and related diseases, functional analysis of cancer genes, and the roles of selection and genomic instability in tumour evolution. The group has combined expertise in human genetics, population genetics, molecular biology and models of disease.

You will work principally on projects that address questions in human cancer susceptibility and tumour evolution. The responsibilities will be varied, but will include sample collection and preparation, experiments on cancer gene function and the analysis of genomic data from patients and their tumours. Experience in all of these areas is needed (see Selection Criteria) although training will be provided in the specialised laboratory techniques involved if required. Technical, academic and analytical/computational ability is required, together with enthusiasm and a high quality of work.

You will have an honours degree and PhD in a relevant subject (applications from PhD students about to submit their theses will be considered) with demonstrable academic and technical ability; experience of the genetic analysis of human diseases, including cancer; experience of the analysis of genome-scale genetic data from human cancers. You will have high-level expertise in phylogenetic, mutation signature and tumour evolution analysis, for example in multiple sample analysis in time and/or space and ability to learn rapidly and master several laboratory techniques. You will also be able to demonstrate commitment to high standards, including record keeping and have good oral, written and electronic communication skills. You will need to be able to work both as part of a team and with some degree of independence and a demonstrable interest in medical research is desirable.

The position is fixed-term until 30th September 2018, with possible extension thereafter depending on available grant funding and funded by Cancer Research UK.

Applications for this position are to be made online. You will be required to upload a CV and supporting statement as part of your online application.

To apply for this role and for further details, including a job description and person specification, please click on the link below:

https://www.recruit.ox.ac.uk/pls/hrisliverecruit/erq_jobspec_version_4.jobspec?p_id=126581

Only applications received before 12.00pm on Friday, 9th December 2016 can be considered. Please quote ref. 126581 on all correspondence.

 

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UNIVERSITY OF OXFORD
POSTDOCTORAL RESEARCH SCIENTIST IN RNA VIRUS GENOMICS 
WELLCOME TRUST CENTRE FOR HUMAN GENETICS, ROOSEVELT DRIVE, HEADINGTON, OXFORD, OX3 7BN 
Grade 7: Salary in the range £31,076 - £32,958p.a.

Applications are invited for a Postdoctoral Research Scientist in RNA Virus Genomics to join the sequencing of Virus Genomics Group at the Wellcome Trust Centre for Human Genetics. Nanopore sequencing is a fast-developing technology in which long reads, portable instruments and the potential to quickly analyse native molecules without copying or amplification are set to revolutionise many investigations in biology and medicine.

You will be responsible primarily for the continuous development of methods for sequencing these human RNA virus pathogens, focusing on the application of Oxford Nanopore Technologies platform(s), specifically the recently released direct RNA sequencing module.

You will have a PhD in a subject relevant to the post, or close to completion, or closely comparable skills and experience with a profound understanding of the molecular biology of cells and nucleic acids, especially with respect to nucleic acid enzymology, nucleic acid hybridisation and enzyme kinetics. You will have extensive hands-on experience and demonstrable ability in the practice, optimisation and development of molecular biology processes such as nucleic acid extraction, sequencing library preparation and quantitation methods including e.g. qPCR, especially at high sample throughput; demonstrable interest in one or more specific aspects of biology and/or medicine, evidenced by an ability to discuss, explain and write about such a subject of personal experience. You will also have a publication record and/or conference attendance at an appropriate level for the stage of career that demonstrates a strong ability to communicate the results and implications of scientific research and demonstrable understanding of the fundamentals of sequence, bioinformatics and evolutionary analyses.

This position is fixed-term for one year in the first instance and funded by the National Institutes of Health (NIH).

To apply for this role and for further details, including a job description and a person specification, please click on the link below:

http://www.ndm.ox.ac.uk/current-job-vacancies/vacancy/126066-Postdoctoral-Research-Scientist-in-RNA-Virus-Genomics

Only applications received before 12.00 midday, on Monday, 12th December 2016 can be considered. Please quote ref. 126066 on all correspondence. You will be required to upload a CV and supporting statement as part of your online application.

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UNIVERSITY OF OXFORD
POSTDOCTORAL RESEARCH SCIENTIST IN NANOPORE SEQUENCE DATA CHARACTERIZATION AND SEQUENCE INFERENCE
WELLCOME TRUST CENTRE FOR HUMAN GENETICS, ROOSEVELT DRIVE, HEADINGTON, OXFORD, OX3 7BN 

Grade 7: Salary in the range £31,076 - £32,958p.a.

Applications are invited for a Postdoctoral Research Scientist in Nanopore Sequence Data Characterization and Sequence Inference to join the Virus Genomics Group at the Wellcome Trust Centre for Human Genetics. Nanopore sequencing is a fast-developing technology in which long reads, portable instruments and the potential to quickly analyse native molecules without copying or amplification are set to revolutionise many investigations in biology and medicine.

You will be primarily responsible for the development of methods for analysing and interpreting Nanopore sequencing data, including raw and/or base-called data, in order to enable a large-scale human RNA virus sequencing project centred on Zika and related viruses. Specific responsibilities will include collaborating with wet-lab staff on the development and optimisation of Nanopore sequencing methods, focusing on the newly released and unique Oxford Nanopore direct RNA sequencing application.

You will have a PhD in statistics, machine learning, or close to completion or a closely related subject with experience in developing methods for signal processing or data analysis in an applied context and demonstrable interest in one or more specific aspects of scientific research, evidenced by an ability to discuss, explain and write about such a subject of personal experience. You will also have extensive experience with R or an equivalent data analysis and programming environment, and strong skills in Python or a similar scripting language and a publication record and/or conference attendance at an appropriate level for the stage of career that demonstrates a strong ability to communicate the results and implications of scientific research.

This position is fixed-term for one year in the first instance and funded by the National Institutes of Health (NIH).

To apply for this role and for further details, including a job description and a person specification, please click on the link below:

http://www.ndm.ox.ac.uk/current-job-vacancies/vacancy/125691-Postdoctoral-Research-Scientist-in-Nanopore-Sequence-Data-Characterization-and-Sequence-Inference

Only applications received before 12.00 midday, on Monday, 12th December 2016 can be considered. Please quote ref. 125691on all correspondence. You will be required to upload a CV and supporting statement as part of your online application.

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UNIVERSITY OF OXFORD
SENIOR POSTDOCTORAL RESEARCHER IN MALARIA EPIDEMIOLOGY
WELLCOME TRUST CENTRE FOR HUMAN GENETICS (MOVING TO BIG DATA INSTITUTE UPON COMPLETION IN EARLY 2017), ROOSEVELT DRIVE, HEADINGTON, OXFORD, OX3 7BN

Grade 8: £39,324 - £46,924 with a discretionary range to £51,260p.a.

Applications are invited for a Senior Postdoctoral Researcher in Malaria Epidemiology to join the Malaria Atlas Project (MAP) at the new Oxford Big Data Institute under the supervision of Professor Peter Gething at the Wellcome Trust Centre for Human Genetics.

Your role is to liaise between the MAP and the NIH project on areas of methodological overlap. You will be required to travel to Madagascar to oversee the project’s field activities. You will develop research questions within a specific context, conduct individual research, analysing detailed and complex qualitative and/or quantitative data from a variety of sources, and generate original ideas by building on existing concepts; develop, establish, and pursue appropriate analytical protocols and techniques to support research and coordinating the research activities of the project’s different partners in Madagascar, the USA and Madagascar to ensure continuity from field surveys, to laboratory activities, to model-based analyses.

You will have a PhD in infectious disease modelling, applied computing, applied mathematics, statistics with a strong publication record and familiarity with the existing literature and research in the field. You will possess sufficient specialist knowledge in the discipline to develop research projects; methodologies and ability to independently plan and manage a research project, including a research budget and experience of coordinating epidemiological surveys. You should also have experience of spatial analysis techniques and thorough knowledge of the epidemiology of malaria, particularly of Plasmodium vivax malaria.

This position is fixed-term until 31 August 2017 and funded by NIH and a CWRU sub-contract.

To apply for this role and for further details, including a job description and a person specification, please click on the link below:

https://www.recruit.ox.ac.uk/pls/hrisliverecruit/erq_jobspec_version_4.jobspec?p_id=126362

Only applications received before 12.00 midday, on Monday 12 December 2016 can be considered. Please quote reference 126362 on all correspondence. You will be required to make your application online and upload a supporting statement.

 

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UNIVERSITY OF OXFORD
RESEARCHER IN INFECTIOUS DISEASE MODELLING 

WELLCOME TRUST CENTRE FOR HUMAN GENETICS (MOVING TO BIG DATA INSTITUTE UPON COMPLETION IN EARLY 2017), ROOSEVELT DRIVE, HEADINGTON, OXFORD, OX3 7BN
Grade 8: £39,324 - £46,924 with a discretionary range to £51,260p.a.

Applications are invited for a Researcher in Infectious Disease Modelling to join the Pathogen Dynamics group at the new Oxford Big Data Institute under the supervision of Professor Christophe Fraser at the Wellcome Trust Centre for Human Genetics. This is an exciting opportunity to join a large team trialling an intervention to tackle the HIV epidemic in Zambia and South Africa.

You will join a team working on the HPTN 071 (PopART) intervention trial, which started in 2014, and where field activities are due to continue for a further two years. In this cluster randomized trial, funded by an international consortium, investigators are testing the hypothesis that HIV transmission can be substantially reduced by a combination of prevention measures delivered to people’s houses, including universal testing and immediate treatment to prevent transmission. The trial is taking place in 21 communities, comprising 1.2 million people, and where adult HIV prevalence ranges from 15% to 30%.

You will have a PhD in infectious disease modelling, applied computing, applied mathematics, statistics, epidemiology or relevant quantitative science, together with relevant experience in modelling or simulation science. You will ppossess sufficient specialist knowledge in infectious disease modelling, epidemiology or simulation science to work within established research programmes and have the ability to independently plan and manager a research project.  In addition you will have a strong publication record and familiarity with the existing literature and research in the field.

An appointment at Grade 7: £31,076 - £38,183 with a discretionary range to £41,709 p.a. may also be considered for a less experienced candidate with suitable adjustment of the responsibilities.

This position is fixed-term for two years in the first instance and funded by the US National Institutes of Health, the US Office of the Global AIDS coordinator, and the Bill and Melinda Gates Foundation.

To apply for this role and for further details, including a job description and a person specification, please click on the link below:

http://www.ndm.ox.ac.uk/current-job-vacancies/vacancy/126184-Researcher-in-Infectious-Disease-Modelling

Only applications received before 12.00 midday, on Wednesday 14 December 2016 can be considered. Please quote reference 126184 on all correspondence. You will be required to make your application online and upload a supporting statement.

 

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UNIVERSITY OF OXFORD
RESEARCHER IN STATISTICAL GENETICS AND PATHOGEN DYNAMICS
WELLCOME TRUST CENTRE FOR HUMAN GENETICS (MOVING TO BIG DATA INSTITUTE UPON COMPLETION IN EARLY 2017), ROOSEVELT DRIVE, HEADINGTON, OXFORD, OX3 7BN

Grade 7: £31,076 - £38,183 with a discretionary range to £41,709 p.a.

Applications are invited for a Researcher in Statistical Genetics and Pathogen Dynamics to join the Pathogen Dynamics group at the new Oxford Big Data Institute under the supervision of Professor Christophe Fraser at the Wellcome Trust Centre for Human Genetics. This is an exciting opportunity to join a large team trialling an intervention to tackle the HIV epidemic in Zambia and South Africa.

Members of the group study the dynamics of several human infectious diseases using both modelling and pathogen genetics, and the post offers substantial opportunities for career development.  This is an exciting opportunity to join a team dedicated to discovering the causes of variation in virulence in HIV-1 infected patients.

You will join a team working on the BEEHIVE project. In this European-wide project, led from Oxford, over 3,000 well-characterised patients are being studied using cutting-edge techniques in viral genomics. The primary aims of the project are 1, to test the role of viral genome variation in determining the severity of infection, and so understand the basis of viral virulence and pathogenesis, 2, to use viral genomics to infer past patterns of epidemic spread across Europe, 3, to test the role of viral genetic diversity in predicting clinical outcomes of treatment.

You will have a PhD in statistical genetics, applied computing, statistics, infectious disease epidemiology, applied mathematics, data sciences, or relevant quantitative science, together with relevant experience in genetics or statistics.  You will possess sufficient specialist knowledge in genetics or pathogen dynamics to work within established research programmes.  In addition you will have experience of contributing to scientific publications or presentations.

This position is fixed-term until 30 April 2019 with a possible renewal for a further year.  It is funded by the European Research Council Advanced Grant ‘Bridging the Evolution and Epidemiology of HIV in Europe’ (BEEHIVE).

To apply for this role and for further details, including a job description and a person specification, please click on the link below:

http://www.ndm.ox.ac.uk/current-job-vacancies/vacancy/125978-Researcher-in-Statistical-Genetics-and-Pathogen-Dynamics

Only applications received before 12.00 midday, on Wednesday 14 December 2016 can be considered. Please quote reference 125978 on all correspondence. You will be required to make your application online and upload a supporting statement.

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UNIVERSITY OF OXFORD
RESEARCH ASSISTANT IN MALARIA ATLAS PROJECT (MAP) - 2 POSTS
WELLCOME TRUST CENTRE FOR HUMAN GENETICS (MOVING TO THE BIG DATA INSTITUTE, OLD ROAD CAMPUS HEADINGTON, UPON COMPLETION) LOCATED AT THE PETER MEDAWAR BUILDING FOR PATHOGEN RESEARCH, UNIVERSITY OF OXFORD, SOUTH PARKS ROAD, OX1 3SY

Grade 6: £27,629 - £32,958 with a discretionary range to £36,001 p.a.

Applications are invited for a Research Assistant in Malaria Atlas Project (MAP), led by Professor Peter Gething.  MAP brings together researchers based around the world with expertise in a wide range of disciplines from public health to mathematics, geography, and epidemiology. We work together to generate new and innovative methods of mapping malaria risk. Ultimately our goal is to produce a comprehensive range of maps and estimates that will support effective planning of malaria control at national and international scales.

Currently, the MAP group is engaged on two flagship programmes: the creation of global prediction maps of malaria prevalence and incidence in collaboration with the Institute of Health Metrics and Evaluation, Washington (led by Professor Peter Gething), and the creation of a suite of databases and online applications to enable effective curation of malariometric data (led by the MAP Programme Manage, Mike Thorn).

The primary role of this position will be to assist core MAP researchers in the preparation of model inputs, implementation of workflows, and dissemination of results, including assisting writing papers for peer reviewed publication and presenting results.  As such, we view this position as a potential springboard towards an academic career and thus we’re seeking an ambitious applicant who is eager to contribute to high-level research.

You will have a first class or upper second class undergraduate degree in a relevant subject and excellent levels of numeracy as evidenced by either a maths A-level, a degree with mathematical content, or work experience requiring strong numeracy skills.  You will have strong data manipulation skills, knowledge of the basics of infectious disease epidemiology, and proficiency in scientific writing.

The position is fixed-term for one year in the first instance and is funded by the Institute of Health Metrics and Evaluation (IHME), The University of Washington, Seattle.

To apply for this role and for further details, including a job description and a person specification, please click on the link below:

http://www.ndm.ox.ac.uk/current-job-vacancies/vacancy/126346-Research-Assistant-in-Malaria-Atlas-Project-(MAP)---2-posts

Only applications received before 12.00 midday, on Monday, 19th December 2016 can be considered. Please quote ref. 126346 on all correspondence. You will be required to upload a CV and supporting statement as part of your online application.

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UNIVERSITY OF OXFORD
LABORATORY SCIENTIFIC OFFICER/HEAD OF SAMPLE PROCESSING
WELLCOME TRUST CENTRE FOR HUMAN GENETICS, ROOSEVELT DRIVE, HEADINGTON, OXFORD, OX3 7BN
Grade 7: £31,076 - £38,183 with a discretionary range to £41,709 p.a.

The Diabetes and Inflammation Laboratory (DIL) relocated from Cambridge to the Wellcome Trust Centre for Human Genetics on 1 October 2016.

Applications are invited for a Laboratory Scientific Officer/Head of Sample Processing to work alongside the Director, Professor John Todd, FRS, and the Co-Director, Professor Linda Wicker, to set up and manage the Sample and Processing operations of the DIL in Oxford. This will comprise a team of research assistants and you will work closely with the Laboratory Manager and the Data Manager.  You will have joint responsibility for the ongoing success of the research programme and will be a key ambassador for the DIL’s approach and mission.

The DIL aims to treat and prevent the causes of the common autoimmune disease, type 1 diabetes (T1D), in which 50% of cases are diagnosed under age 18 years and consequently run the highest risk of serious complications. This unmet clinical need requires an understanding of the underlying mechanisms of disease.

Our interdisciplinary research programme – from disease gene discovery to translational clinical studies – involves national and international collaborations and funding agencies.  The DIL is a vibrant, enthusiastic, innovative and strategic enterprise in an internationally-leading position to make a real difference, not only to diabetes families in the future, but also to contributing significantly to basic knowledge of the disease process, and to develop and apply research methods and experimental medicine approaches. We have a fantastic track record of success and a reputation for a can-do attitude to tackling challenging research goals.  At the heart of the DIL is a deep commitment to training and career development of laboratory, computer and statistical scientists.

You will have proven ability in laboratory management in a medical research environment, a BSc degree in a biological subject plus experience involving high throughout laboratory techniques, and significant experience of sample handling for large scale research studies. You will have strong communication skills, including proven ability in report writing, and the ability to work independently using your own initiative. You will have the ability to establish effective working relationships with senior academic, clinical, research, and support staff, and will have the ability to work closely with the research team to co-ordinate work flows. A track record of project management and a relevant postgraduate or professional qualification are desirable.

The post is available for a fixed term until 30 September 2020 in the first instance and is funded by the Wellcome Trust.

To apply for this role and for further details, including a job description and person specification, please click on the link below:

http://www.ndm.ox.ac.uk/current-job-vacancies/vacancy/126467-Laboratory-Scientific-Officer/Head-of-Sample-Processing

Only applications received before 12pm, Monday 9 January 2017 can be considered. Please quote ref. 126467 on all correspondence. Interviews will take place in the week commencing 23 January 2017.

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