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POSTDOCTORAL RESEARCH SCIENTIST IN STRUBI
DIVISION OF STRUCTURAL BIOLOGY, WELLCOME TRUST CENTRE FOR HUMAN GENETICS, ROOSEVELT DRIVE, HEADINGTON, OXFORD, OX3 7BN

Grade 7: £ 31,076 to £ 38,183 with a discretionary range to £ 41,709 per annum

Applications are invited for a Postdoctoral Research Scientist  in STRUBI to join a National Institute of Health funded project in Professor Peijun Zhang group based in the Division of Structural Biology at the Wellcome Trust Centre for Human Genetics.

The project aims to investigate transmembrane protein SERINCs and their functional role in HIV-1 infection. You will carry out structural and functional analyses of HIV-1 virions produced from the cells in the presence or absence of SERINCs, as well as cryo-correlative light and electron tomography (cryo-CLEM) of membrane fusion between viral particles with or without SERINCs, and target cells expressing CD4 and CXCR4 or CCR5.

You will manage the project day-to-day, including both design and action of strategies in molecular biology, protein expression, fluorescence labelling, structural analysis using cryoEM and other appropriate methods. You will use specialist scientific equipment in a laboratory environment, including cryo-electron microscopes and optical microscopes. You will act as a source of information and advice to other group members and will act in a co-supervisory role towards graduate students within the research programme. You will carry out collaborative projects with partner research groups and contribute to the preparation of scientific results and the overall development of the programme.

You will have a PhD/DPhil in the structural and functional studies of proteins and protein complexes or in exceptional cases expected to obtain soon. You will have a research experience in production and purification of proteins for structure/function studies using mammalian and E. coli expression systems; research experience in X-ray crystallography including both experimental and model-based phasing, and a willingness to learn cryoEM techniques and research experience in biophysical and cell-based assays, especially analytical ultracentrifugation and surface plasmon resonance.

You will also have an ability to manage the day-to-day running of a research project including assisting the work of junior researchers; a good publication record, including work at level of first author in a leading referred journal, and have good written and oral communication skills. Research on protein-protein interactions expression are desirable.

The position is fixed term contract until 30th June 2018 in the first instance and funded by the National Institute of Health.

To apply for this role and for further details, including a job description and person specification, please click on the link below:

http://www.ndm.ox.ac.uk/current-job-vacancies/vacancy/129709-Postdoctoral-Research-Scientist-in-STRUBI  

Only applications received before 12:00 midday on Monday 7 August 2017 can be considered.

Please quote ref. 129709 on all correspondence. You will be required to upload a CV and supporting statement as part of your online application.

 

 

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POSTDOCTORAL RESEARCH FELLOW IN CORRELATIVE MIRCOSCOPY
DIVISION OF STRUCTURAL BIOLOGY, WELLCOME TRUST CENTRE FOR HUMAN GENETICS, ROOSEVELT DRIVE, HEADINGTON, OXFORD, OX3 7BN

Grade 7: £ 31,076 to £ 38,183 with a discretionary range to £ 41,709 per annum

Applications are invited for a Postdoctoral Research Fellow in Correlative Microscopy to join a Wellcome funded project in Professor Peijun Zhang group based in the Division of Structural Biology at the Wellcome Trust Centre for Human Genetics.

This project aims to define the effects of host factors on the function of capsid and viral infectivity in the context of native host cells, using cellular cryo-electron tomography (cryoET) and correlative live-cell and cryoET imaging in super-resolution. In collaboration with OPIC and Micron in Oxford, and eBIC in Diamond Light Source, you will further develop a correlative super-resolution microscopy workflow, in conjunction with cryoFIB, to gain a detailed spatial and temporal understanding of HIV-1 and host cell interactions.

You will manage the project day-to-day, including both design and action of strategies in molecular biology, protein expression and depletion by siRNA and CRISPR/Cas9, cell culture, virus infection, and fluorescence labelling of viruses and target host proteins. You will use specialist scientific equipment in a laboratory environment, including super-resolution optical microscopes and cryoEM. You will act as a source of information and advice to other group members and will act in a co-supervisory role towards graduate students within the research programme. You will contribute to the preparation of scientific results and the overall development of the programme.

You will have a PhD/DPhil in the structural and functional studies of proteins and protein interactions or in exceptional cases expected to obtain soon. You will have a research experience in cryoEM techniques, in particular cryoET, and fluorescence light microscopy and substantial experience in molecular biology, cell culture, protein depletion/knockdown, protein labeling and expression. You should also have a good publication record, including work at level of first author in a leading referred journal, and have good written and oral communication skills. Research experience in biochemical, biophysical and cell-based assays; in retroviruses and viral infection and in super-resolution optical microscopy are desirable.

The position is fixed term until 31st May 2020 and funded by the Wellcome Trust.

To apply for this role and for further details, including a job description and person specification, please click on the link below:

http://www.ndm.ox.ac.uk/current-job-vacancies/vacancy/129296-Postdoctoral-Research-Fellow-in-Correlative-Microscopy

Only applications received before 12:00 midday on Monday 7 August 2017 can be considered.

Please quote ref. 129296 on all correspondence. You will be required to upload a CV and supporting statement as part of your online application.

 

 

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POSTDOCTORAL RESEARCH FELLOW IN HIV-HOST INTERACTIONS
DIVISION OF STRUCTURAL BIOLOGY, WELLCOME TRUST CENTRE FOR HUMAN GENETICS, ROOSEVELT DRIVE, HEADINGTON, OXFORD, OX3 7BN

Grade 7: £ 31,076 to £ 38,183 with a discretionary range to £ 41,709 per annum

Applications are invited for a Postdoctoral Research Fellow in HIV-host interactions to join a Wellcome funded project in Professor Peijun Zhang group based in the Division of Structural Biology at the Wellcome Trust Centre for Human Genetics.

The project is focused on determining the mechanism of capsid-pattern sensing by host cell defense proteins and examining the consequence for HIV-1 infection upon alteration of host protein’s pattern-sensing ability. To define the molecular mechanism by which host factors act on the function of capsid and viral infectivity, we are carrying out structural and functional studies of HIV-1 capsid and host factor complexes using cyroEM methods, combined with computation, mutagenesis and functional assays.

You will manage the project day-to-day, including both design and action of strategies in molecular biology, protein expression and purification, structural studies using cryoEM and other appropriate methods. You will use specialist scientific equipment in a laboratory environment and will act as a source of information and advice to other group members and will act in a co-supervisory role towards graduate students within the research programme. You will carry out collaborative projects with partner research groups and contribute to the preparation of scientific results and the overall development of the programme.

You will have a PhD/DPhil in the structural and functional studies of proteins and protein complexes or in exceptional cases expected to obtain soon. You will have a research experience in production and purification of proteins for structure/function studies using mammalian and E. coli expression systems; research experience in cryoEM and cryoET, and/or X-ray crystallography including both experimental and computational and substantial experience in protein biochemistry and structural biology. You should also demonstrate a good publication record, including work at level of first author in a leading referred journal, and have good written and oral communication skills.

The position is fixed term until 31st May 2020 and funded by the Wellcome Trust.

To apply for this role and for further details, including a job description and person specification, please click on the link below:

http://www.ndm.ox.ac.uk/current-job-vacancies/vacancy/129294-Postdoctoral-Research-Fellow-in-HIV-host-interactions

Only applications received before 12:00 midday on Monday 7 August 2017 can be considered.

Please quote ref. 129294 on all correspondence. You will be required to upload a CV and supporting statement as part of your online application.

 

 

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POSTDOCTORAL RESEARCH SCIENTIST IN TRANSGENIC TECHNOLOGIES
WELLCOME TRUST CENTRE FOR HUMAN GENETICS, ROOSEVELT DRIVE, HEADINGTON, OXFORD, OX3 7BN
Grade 7: £31,076 - £38,183 p.a. (with a discretionary range to £41,709p.a.)

Applications are invited for a Postdoctoral Research Scientist in Transgenic Technologies to join a research project in Dr. Ben Davies’s group based at the Wellcome Trust Centre for Human Genetics, funded by the NC3Rs (National Centre for the Replacement, Refinement and Reduction of Animals in Research).

The project involves the development of new protocols for CRISPR-Cas9 mutagenesis in mouse embryos, aimed at addressing various shortcomings which might limit the full 3Rs potential of this technology to be realised. We seek an enthusiastic and motivated postdoctoral research scientist, reporting to the group leader, who will be perform high quality research to meet the research aims of the project.

You will have a PhD in Molecular Biology, Biochemistry, Genetics, a related discipline or expectation that your thesis will be submitted before August 2017 and expertise and detailed knowledge of CRISPR/Cas9 technology. You will have experience with handling pre-implantation embryos; experience with complex molecular biology and genotyping techniques; experience of scientific computing using at least one programming language and proven experience in scientific project management. You will have excellent communication skills and evidence of ability to conduct and complete high quality research both independently and in collaboration.

The position is fixed-term for three years in the first instance and funded by the National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs).

To apply for this role and for further details, including a job description and person specification, please click on the link below:

http://www.ndm.ox.ac.uk/current-job-vacancies/vacancy/130152-Postdoctoral-Research-Scientist-in-Transgenic-Technologies 

Only applications received before 12.00 midday on Monday, 7 August 2017 can be considered. Please quote reference 130152 on all correspondence. You will be required to upload a CV and supporting statement as part of your online application.

Interviews will take place on Tuesday 15th August 2017.