Research jobs                             HR

 

 

 

 

Postdoctoral Bioinformatician

Wellcome Centre for Human Genetics, Roosevelt Drive, Headington, Oxford, OX3 7BN

Grade 8: £40,792 - £48,677 p.a.

Applications are invited for a Postdoctoral Bioinformatician in Dr Simon Leedham’s research group at the Wellcome Centre for Human Genetics.

We are looking for a Postdoctoral Bioinformatician in cancer, with interests in the fields of cancer genomics or transcriptomics. You will take the lead in providing bioinformatics expertise to this multi-disciplinary team by processing, analysing and interrogating bioinformatics data, creating mathematical models, and performing pattern analyses of biological systems to find and apply bioinformatics solutions to biomedical problems.

You will conduct detailed analysis of datasets and carry out data processing and integration, statistical analysis, presentation and interpretation of bioinformatics data. You will develop informatics structures to manage large datasets, including the organisation of data storage and repository solutions that meet current publishing standards.

You will have a very good first degree in a relevant subject and a PhD in Biostatistics, Mathematics, Statistics, Computing, Mathematical Biology or a related subject as well as several years’ demonstrable experience, ability and practical success in biostatistics or bioinformatics. You will have proficiency in the use of statistical programming languages such as R/BioConductor and have excellent data analysis skills, including experience with analysing RNAseq data and next generation sequencing data.

You will also have the ability to work efficiently and intensively, both independently and as part of a team and demonstrable ability to organise and prioritise work efficiently whilst delivering results to the required standard and to an agreed schedule.

The position is fixed term until 1 January 2021 in the first instance and funded by the Wellcome.

To apply for this role and for further details, including a job description and person specification, please click on the link below:

https://www.ndm.ox.ac.uk/current-job-vacancies/vacancy/137179-Postdoctoral-Bioinformatician

Only applications received before 12:00 midday on Monday 22 October 2018 can be considered.

Please quote ref. 137179 on all correspondence. You will be required to upload a CV and supporting statement as part of your online application.

 

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Research Assistant in Functional Genomics

Wellcome Centre for Human Genetics, Roosevelt Drive, Headington, Oxford, OX3 7BN

Grade 6: £28,660 – 34,189 p.a.  

Applications are invited for a Research Assistant in Functional Genomics at the Functional Genomics of Immunity Group, led by Professor Julian Knight, based in the Wellcome Centre for Human Genetics.

You will play a key role in a substantial research programme aiming to use functional genomic approaches to define regulatory genetic variants that are responsible for observed associations with susceptibility to disease found by recent genome-wide association studies.

You will be responsible for managing on-going sample collections from recruited patients and healthy volunteers, including separation of peripheral blood samples into different leukocyte populations, flow cytometry analysis, purifying DNA, RNA and chromatin, and application of different cutting-edge genomic approaches including whole genome sequencing, RNA-sequencing and assays of chromatin accessibility and chromatin interactions.

You will have a degree in genetics, biochemistry, molecular biology or related field. You will have experience in tissue culture and standard molecular biology techniques and experience of functional genomic protocols. You will have the ability to organise and prioritise work efficiently delivering results to required standard and to an agreed schedule alongside with demonstrable high level of communication skills both written and oral and ability to work within a team effectively.

The position is funded by Specialist Diabetes Research and Treatment Centre LLC and is fixed-term until 31 December 2020 in the first instance.

Applications for this vacancy are to be made online. You will be required to upload a CV and supporting statement as part of your online application.

To apply for this role and for further details, including a job description and person specification, please click on the link below:

https://www.ndm.ox.ac.uk/current-job-vacancies/vacancy/136524-Research-Assistant-in-Functional-Genomics

Only applications received before 12.00 midday on Monday 15 October 2018 can be considered.

Please quote ref. 136524 on all correspondence.  

 

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 FACS Facility Manager

Wellcome Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN

Grade 7: £32,236 - £39,609 p.a. (with a discretionary range to £43,267 p.a.)

The Wellcome Centre for Human Genetics, one of the world’s leading research institutes in the field of human genetics, is seeking a FACS Facility Manager to be responsible for running, maintaining, and developing the Centre’s FACS core services.

Reporting to the Head of the Chromosome Dynamics Core Facility, you will be responsible for establishing working protocols, training users, organising user liaison forums, managing bookings, and ensuring all required maintenance and development is undertaken to maintain an effective service. You will interact with the Centre’s scientists directly, supporting a wide range of research programmes in cell and molecular biology, immunology, and virology, and you will also act as a focal point for collaborations between scientific groups.

You will have a PhD (or close to completion) or extensive equivalent experience in a relevant subject in biological sciences with basic knowledge of cell biology, experience with multi-colour, multi-dimensional flow cytometric equipment, and demonstrable hands-on experience in producing high quality, high-throughput cell sorting and flow cytometric analysis, using a variety of sample sources.

You will have excellent interpersonal skills and experience of interacting with diverse groups of researchff and students, as well as a proven good work ethic and proven ability in trouble-shooting in the design and execution of experimental protocols. Excellent communication, time management, and organisation skills are essential, as is a strong drive to learn and develop your skills within a highly dynamic setting.

The post is fixed-term contract until 30 November 2021 and funded by the Wellcome.

To apply for this role and for further details, including a job description and a person specification, please click on the link below:

https://www.ndm.ox.ac.uk/current-job-vacancies/vacancy/136888-FACS-Facility-Manager

Only applications received before 12:00 midday on Wednesday 14 November 2018 can be considered. Interviews are expected to be held on 27-29 November 2018.

Please quote reference 136888 on all correspondence. You will be required to upload a CV and supporting statement as part of your online application.

 

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Postdoctoral Research Fellow in HIV-host Interactions

Division of Structural Biology, Wellcome Centre for Human Genetics, Roosevelt Drive, Headington, Oxford, OX3 7BN

Grade 7: £32,236 - £39,609 p.a. (with a discretionary range to £43,267 p.a.)

Applications are invited for a Postdoctoral Research Fellow in HIV-host Interactions to join a Wellcome funded project in Professor Peijun Zhang group based in the Division of Structural Biology at the Wellcome Trust Centre for Human Genetics.

The project is focused on defining the molecular mechanism by which host factors act on the function of capsid and viral infectivity, by carrying out structural and functional studies of HIV-1 capsid and host factor complexes using cyroEM methods, combined with mutagenesis and functional assays.

You will manage the project day-to-day, including both design and action of strategies in molecular biology, protein expression and purification, structural studies using cryoEM and other appropriate methods. You will use specialist scientific equipment in a laboratory environment and will act as a source of information and advice to other group members and will act in a co-supervisory role towards graduate students within the research programme. You will carry out collaborative projects with partner research groups and contribute to the preparation of scientific results and the overall development of the programme.

You will have a PhD/DPhil (or in exceptional cases expected to obtain soon) in the structural and functional studies of proteins and protein complexes with a research experience in production and purification of proteins for structure/function studies using mammalian and E. coli expression systems; research experience in cryoEM, and/or X-ray crystallography including both experimental and computational; and with substantial research experience in protein biochemistry and structural biology. You should demonstrate a good publication record, including work at level of first author in a leading referred journal, and have good written and oral communication skills. Ability to manage the day-to-day running of a research project including assisting the work of junior researchers is also essential.

The position is fixed term until 31 May 2020 in the first instance and funded by the Wellcome.

To apply for this role and for further details, including a job description and person specification, please click on the link below:

https://www.ndm.ox.ac.uk/current-job-vacancies/vacancy/137029-Postdoctoral-Research-Fellow-in-HIV-host-Interactions

Only applications received before 12:00 midday on Monday 12 November 2018 can be considered.

Please quote ref. 137029 on all correspondence. You will be required to upload a CV and supporting statement as part of your online application.

 

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Postdoctoral Research Fellow in HIV-host Interactions

Division of Structural Biology, Wellcome Centre for Human Genetics, Roosevelt Drive, Headington, Oxford, OX3 7BN

Grade 7: £32,236 - £39,609 p.a. (with a discretionary range to £43,267 p.a.)

Applications are invited for a Postdoctoral Research Fellow in HIV-host Interactions to join a Wellcome funded project in Professor Peijun Zhang group based in the Division of Structural Biology at the Wellcome Trust Centre for Human Genetics.

Using cutting-edge cryoEM technologies, combined with mutagenesis and functional assays, this project aim to determine the molecular interactions between the viral capsid and host restriction factors that underpin their capsid pattern-sensing capability and ability to inhibit HIV-1 replication.

You will manage the project day-to-day, including both design and action of strategies in molecular biology, protein expression and purification, structural studies using cryoEM and other appropriate methods. You will use specialist scientific equipment in a laboratory environment and will act as a source of information and advice to other group members and will act in a co-supervisory role towards graduate students within the research programme. You will carry out collaborative projects with partner research groups and contribute to the preparation of scientific results and the overall development of the programme.

You will have a PhD/DPhil (or in exceptional cases expected to obtain soon) in the structural and functional studies of proteins and protein complexes with a research experience in production and purification of proteins for structure/function studies using mammalian and E. coli expression systems; research experience in cryoEM, and/or X-ray crystallography including both experimental and computational; and with substantial research experience in protein biochemistry and structural biology. You should demonstrate a good publication record, including work at level of first author in a leading referred journal, and have good written and oral communication skills. Ability to manage the day-to-day running of a research project including assisting the work of junior researchers is also essential.

The position is fixed term until 31 December 2021 in the first instance and funded by the Wellcome.

To apply for this role and for further details, including a job description and person specification, please click on the link below:

https://www.ndm.ox.ac.uk/current-job-vacancies/vacancy/137630-Postdoctoral-Research-Fellow-in-HIV-host-Interactions

Only applications received before 12:00 midday on Monday 12 November 2018 can be considered.

Please quote ref. 137630 on all correspondence. You will be required to upload a CV and supporting statement as part of your online application.

 

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Postdoctoral Research Scientist in Single Cell Analysis of Adaptive Immunity

Wellcome Centre for Human Genetics, Roosevelt Drive, Headington, Oxford, OX3 7BN

Grade 7: £32,236 - £39,609 p.a. (with a discretionary range to £43,267 p.a.)

Applications are invited for a Postdoctoral Research Scientist in Single Cell Analysis of Adaptive Immunity within Adaptive Immunity Group led by Dr Rachael Bashford-Rogers based at the Wellcome Centre for Human Genetics.

You will be a member of a research group and involved in an exciting research programme with responsibility for characterising the effect of genetic and environmental variation on B and T cell fate in health and disease using single cell transcriptomics across a range of diseases and tissues in patients, determining changes associated with genetic, environmental factors, and different therapeutic approaches. You will be developing and applying novel single-cell experimental and computational approaches to clinical samples, and will be working in partnership with a global network of clinicians, immunologists and sample cohorts.

You will hold a relevant PhD/Dphil PhD (or, in exceptional cases, expected to obtain soon) and prior research skills in molecular biology including isolating, staining and FACS sorting primary human cells or tissues. You will preferably have prior experience performing RNA-seq (library preparation and next generation sequencing) for bulk or single cells; prior experience of computational data analysis of genetic data and expertise in human immunology - investigating immunological or genetic pathophysiological mechanisms underlying immune-mediated diseases. You will have excellent written and oral communication skills and the ability to work as part of a team as well as independently. You will have demonstrable ability to manage the day-to-day running of a research project from initiation to completion, including assisting the work of junior researchers and technicians, and managing resources effectively.

The position is fixed term for 2 years in the first instance and funded by the Department.

To apply for this role and for further details, including a job description and person specification, please click on the link below:

https://www.ndm.ox.ac.uk/current-job-vacancies/vacancy/136522-Postdoctoral-Research-Scientist-in-Single-Cell-Analysis-of-Adaptive-Immunity

Only applications received before 12:00 midday on Wednesday 14 November 2018 can be considered.

Please quote ref. 136522 on all correspondence. You will be required to upload a CV and supporting statement as part of your online application.

 

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Postdoctoral Research Fellow in bacterial chemotaxis signalling

Division of Structural Biology, Wellcome Centre for Human Genetics, Roosevelt Drive, Headington, Oxford, OX3 7BN

Grade 7: £32,236 - £39,609 p.a. (with a discretionary range to £43,267 p.a.)

Applications are invited for a Postdoctoral Research Fellow in bacterial chemotaxis signalling to join a BBSRC funded project in Professor Peijun Zhang group based in the Division of Structural Biology at the Wellcome Centre for Human Genetics.

This project is focused on understanding the underlying molecular mechanisms of chemosensory array assembly, activation upon binding of its stimulus and high cooperativity, by determining the precise interactions between the core signalling components, in vitro and in native cells.

You will manage the project day-to-day, including both design and action of strategies in molecular biology, protein expression and purification, in vitro reconstitution, structural studies using cryoEM and other appropriate methods, and publication of results. You will use specialist scientific equipment in a laboratory environment and will act as a source of information and advice to other group members and will act in a co-supervisory role towards graduate students within the research programme. You will carry out collaborative projects with partner research groups and contribute to the preparation of scientific results and the overall development of the programme.

You will have a PhD/DPhil (or in exceptional cases expected to obtain soon) in the structural and functional studies of proteins and protein complexes with a research experience in production and purification of proteins for structure/function studies; research experience in cryoEM, and/or X-ray crystallography including both experimental and computational; and with substantial research experience in protein biochemistry and structural biology. You should demonstrate a good publication record, including work at level of first author in a leading referred journal, and have good written and oral communication skills. Ability to manage the day-to-day running of a research project including assisting the work of junior researchers is also essential.

The position is fixed term until 30 September 2021 in the first instance and funded by the BBSRC.

To apply for this role and for further details, including a job description and person specification, please click on the link below:

https://www.ndm.ox.ac.uk/current-job-vacancies/vacancy/137030-Postdoctoral-Research-Fellow-in-bacterial-chemotaxis-signalling

Only applications received before 12:00 midday on Monday 12 November 2018 can be considered.

Please quote ref. 137030 on all correspondence. You will be required to upload a CV and supporting statement as part of your online application.

 

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Data Analyst in the Diabetes and Inflammation Laboratory (DIL)

Wellcome Centre for Human Genetics, Roosevelt Drive, Headington, Oxford, OX3 7BN

Grade 7: £32,236 - £39,609 p.a. (with a discretionary range to £43,267 p.a.)

Applications are invited for a Data Analyst in the Diabetes and Inflammation Laboratory (DIL) at the Wellcome Centre for Human Genetics.

The DIL aims to treat and prevent the causes of the common autoimmune disease, type 1 diabetes (T1D), in which 50% of cases are diagnosed under age 18 years and consequently run the highest risk of serious complications. This unmet clinical need requires an understanding of the underlying mechanisms of disease.

You will provide data management support to DIL research activities. The primary focus of this role will be coordinating the ongoing roll-out of the sample inventory software within the DIL; this will require the post holder to establish close working relationships with the researchers and Sample Processing Team.

This is an exciting opportunity to implement and develop new software and technologies which will make a real difference to the functionality and efficiency our research and clinical trials.

You will have a degree in a relevant subject and a post-graduate degree (or near completion) or demonstrable professional experience in Biostatistics, Mathematics, Statistics, Computing, Mathematical Biology or a related subject as well as demonstrable experience, ability and practical success in biostatistics or bioinformatics. You will also have proficiency in the use of statistical programming languages such as evidence of implementing, developing, maintaining and testing SQL and relational database technologies, including interfacing and integration between applications; experience of developing complete computer applications from gathering user requirements, through development and test to implementation and support and experience with web-based technologies: HTML, JavaScript, XML and CSS.

Demonstrable ability to organise and prioritise work efficiently whilst delivering results to the required standard and to an agreed schedule is essential as is excellent communication skills and ability to work effectively within a team.

The position is fixed term until 30 September 2020, in the first instance and funded by the JDRF.

To apply for this role and for further details, including a job description and person specification, please click on the link below:

https://www.ndm.ox.ac.uk/current-job-vacancies/vacancy/136885-Data-Analyst

Only applications received before 12:00 midday on Monday 19 November 2018 can be considered.

Please quote ref. 136885 on all correspondence. You will be required to upload a CV and supporting statement as part of your online application.