HR

Research

 

 

 

UNIVERSITY OF OXFORD 
SENIOR CLINICAL TRIAL MANAGER
WELLCOME TRUST CENTRE FOR HUMAN GENETICS, ROOSEVELT DRIVE, HEADINGTON, OXFORD, OX3 7BN
Grade 8: £39,324 - £46,924 with a discretionary range to £51,260 p.a.

A lower grade offer may be made (Grade 7: £31,076 - £38,183 p.a.) with commensurate reduction in responsibilities if a suitable candidate cannot be found to fill the Grade 8 position.

The JDRF/Wellcome Trust Diabetes and Inflammation Laboratory (DIL) relocated from Cambridge to the Wellcome Trust Centre for Human Genetics on 1 October 2016.  

Applications are invited for a Senior Clinical Trial Manager to be responsible for the overall management of the DIL’s next trial of interleukin-2 (IL-2) in the treatment of T1D, Interleukin-2 therapy of autoimmunity and disease (ITAD).  In addition, you will work with the Director, Professor John Todd, FRS, in initiating, developing and executing other prevention and intervention trials in T1D, in adults and in children. 

You will have a degree in a relevant biomedical or associated subject, with a demonstrable experience of coordinating clinical trials and have experience of line-managing clinical trial staff, including providing training on clinical research projects.  You will have in-depth working knowledge of existing UK clinical research structures, GCP and regulatory and ethical systems.  Presentation, negotiation and interpersonal skills, including the ability to make and sustain good working contacts with a variety of research professionals will be essential as is the ability to work on your own initiative and problem solve. You need to be able to demonstrate critical and intelligent attention to detail and have high standards of accuracy.  You need to be able to travel easily in the UK and further afield on occasion, possibly requiring overnight stays.

Experience of QA systems, trial audit and monitoring applicable to clinical research, including development of written procedures for clinical trials run to high levels of GCP is desirable.  Other desirable skills are experience of clinical research in paediatrics and/or diabetes, experience of developing funding/grant applications, experience of trial contracting, trial budget management and managing trials in a non-commercial (academic) setting.   A working knowledge of clinical research structures, ethical and regulatory systems in EU Member States is also desirable.

The post is available until 30 September 2020 in the first instance and is funded by the JDRF.

Applications for this vacancy are to be made online. To apply for this role and for further details, including a job description and person specification, please click on the link below:

http://www.ndm.ox.ac.uk/current-job-vacancies/vacancy/126948-Senior-Clinical-Trial-Manager

Only applications received before 12pm, Friday 20th January 2017 can be considered. Please quote reference 126948 on all correspondence. Interviews to take place on 27 January 2017.

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UNIVERSITY OF OXFORD
RESEARCH ASSISTANT - DIABETES AND INFLAMMATION LABORATORY (2 POSTS) WELLCOME TRUST CENTRE FOR HUMAN GENETICS, ROOSEVELT DRIVE, HEADINGTON, OXFORD, OX3 7BN
Grade 6: £27,629 - £32,958 pa with a discretionary range to £36,001 p.a.

Applications are invited for a Research Assistant to join the JDRF/Wellcome Trust Diabetes and Inflammation Laboratory (DIL).  As a member of the DIL you will have responsibility for the provision of research support in genetic/genomic analyses of regions of the genome altering risk of autoimmune diabetes, in the analysis of the immune system in blood samples from patients and healthy volunteers. 

Our interdisciplinary research programme – from disease gene discovery to translational clinical studies – involves national and international collaborations and funding agencies.  The DIL is a vibrant, enthusiastic, innovative and strategic enterprise in an internationally-leading position to make a real difference, not only to diabetes families in the future, but also to contributing significantly to basic knowledge of the disease process, and to develop and apply research methods and experimental medicine approaches. We have a fantastic track record of success and a reputation for a can-do attitude to tackling challenging research goals.  At the heart of the DIL is a deep commitment to training and career development of laboratory, computer and statistical scientists.

You will hold a first degree, together with some relevant experience and possess sufficient specialist knowledge in the discipline to work within established research programmes.  The ability to manage own research work and administrative activities is essential.  It is also essential that you have excellent communication skills, including the ability to write text that can be published, present data at conferences, and represent the research group at meetings.  You will have experience of following and adapting protocols and developing and selecting appropriate experimental methodologies.  Your skills will include bioinformatics, flow cytometry, RNA sequence expression, protein expression using ELISA, western blotting, microscopy and molecular biology. 

The two posts are available until 30 September 2020 in the first instance.  Post 1 is funded by the Wellcome Trust and Post 2 is funded by the JDRF.  We are willing to consider applications from those wishing to work part-time, at no less than 0.6 FTE for the post funded by the JDRF.  If you wish to be considered for part-time work, please indicate this clearly in your application.

Applications for this vacancy are to be made online. To apply for this role and for further details, including a job description and person specification, please click on the link below:

http://www.ndm.ox.ac.uk/current-job-vacancies/vacancy/126585-Research-Assistant-in-DIL-–-2-posts

Only applications received before 12pm, Monday 23 January 2017 can be considered. Please quote reference 126585 on all correspondence. Interviews to take place on 2 February 2017.

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UNIVERSITY OF OXFORD
RESEARCH ASSISTANT IN VACCINE DEVELOPMENT
CENTRE FOR CELLULAR AND MOLECULAR PHYSIOLOGY, JENNER INSTITUTE, HENRY WELLCOME BUILDING FOR MOLECULAR PHYSIOLOGY, ROOSEVELT DRIVE, HEADINGTON, OXOFRD, OX3 7BN

Grade 6: £27,629 - £31,076 p.a

Applications are invited for a Research Assistant in Vaccine Development at the Jenner Institute located at the Centre for Cellular and Molecular Physiology, Wellcome Trust Centre for Human Genetics.

You will work on the development of vaccines against arboviruses, in particular Zika, Dengue and Chikungunya. The post-holder will perform the pre-clinical work to assess efficacy of new vaccine candidates, as well as the development of new vaccine candidates in the form of proteins or recombinant viral vectors.

You will be principally involved in performing in vivo procedures, isolating suitable samples to assess the outcome of an immunization by flow cytometry, ELISPOT and ELISA techniques. Additional work will include protein vaccine production, cell culture and molecular biology techniques such as the use of restriction enzymes to clone transgenes into plasmids/vectors.

You will be required to support the Principal Investigator and other senior, junior researchers and students in the day-to-day work of this project. You will supply information to the team and project manager to support tracking progress against objectives and compiling project reports in a timely manner for efficient running of the projects.

You will have a degree in biological sciences and you should have the ability to work independently and with own initiative whilst reporting regularly to Project Leader and project manager about work progress and assignment of priorities and resources with excellent interpersonal skills, including ability to form relationships with key stakeholders. You will have excellent verbal and written communication skills, including ability to communicate with people from multiple disciplines, particularly clinicians, scientists and bioinformaticians and excellent organisation skills, with the ability to prioritise tasks, adapt to changing demands and manage a complex workload of their own and that of other project members to work together to meet deadlines.

The position is fixed-term contract until 30 September 2017, with possibility for extension until March 2018 and funded by Innovate UK.

To apply for this role and for further details, including a job description and a person specification, please click on the link below:

http://www.ndm.ox.ac.uk/current-job-vacancies/vacancy/126928-Research-Assistant-in-Vaccine-Development

Only applications received before 12.00 midday, on Thursday 26th January 2017 can be considered. Please quote ref. 126928 on all correspondence. You will be required to upload a CV and supporting statement as part of your online application.

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UNIVERSITY OF OXFORD
POSTDOCTORAL RESEARCH SCIENTIST - DIABETES AND INFLAMMATION LABORATORY (2 POSTS)
WELLCOME TRUST CENTRE FOR HUMAN GENETICS, ROOSEVELT DRIVE, HEADINGTON, OXFORD, OX3 7BN
Grade 7: £31,076 - £38,183 pa with a discretionary range to £41,709 p.a.

The JDRF/Wellcome Trust Diabetes and Inflammation Laboratory (DIL) relocated from Cambridge to the Wellcome Trust Centre for Human Genetics on 1 October 2016. 

Applications are invited for a Postdoctoral Research Scientist in DIL to lead on one or more research projects, including genetic/genomic analyses of regions of the genome altering risk of autoimmune diabetes, in the analysis of the immune system in blood samples from patients and healthy volunteers and in the role of amyloidgenic proteins in pancreatic beta cells and other cells outside the brain. You will also provide advice and guidance to research students where appropriate and assist in the preparation of grant applications.

Our interdisciplinary research programme – from disease gene discovery to translational clinical studies – involves national and international collaborations and funding agencies.  The DIL is a vibrant, enthusiastic, innovative and strategic enterprise in an internationally-leading position to make a real difference, not only to diabetes families in the future, but also to contributing significantly to basic knowledge of the disease process, and to develop and apply research methods and experimental medicine approaches. We have a fantastic track record of success and a reputation for a can-do attitude to tackling challenging research goals.  At the heart of the DIL is a deep commitment to training and career development of laboratory, computer and statistical scientists.

You will hold a PhD or equivalent in an appropriate area, such as immunology, cell biology, genetics, genomics.  You will possess sufficient specialist knowledge in the discipline to work within established research programmes.  The ability to manage own research work and administrative activities is essential.  It is also essential that you have excellent communication skills, including the ability to write text that can be published, present data at conferences, and represent the research group at meetings.  You will have experience of following and adapting protocols and developing and selecting appropriate experimental methodologies.  Your skills will include bioinformatics, flow cytometry, RNA sequence expression, protein expression using ELISA, western blotting, microscopy and molecular biology. 

The two posts are available until 30 September 2020 in the first instance.  Post 1 is funded by the Wellcome Trust and Post 2 is funded by the JDRF.

Applications for this vacancy are to be made online. To apply for this role and for further details, including a job description and person specification, please click on the link below:

http://www.ndm.ox.ac.uk/current-job-vacancies/vacancy/127054-Postdoctoral-Research-Scientists-in-DIL-–-2-posts

Only applications received before 12pm, Monday 30 January 2017 can be considered. Please quote reference 127054 on all correspondence. Interviews to take place on 9 February 2017.

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UNIVERSITY OF OXFORD
POSTDOCTORAL RESEARCH SCIENTIST IN STRUBI - 2 POSTS
DIVISION OF STRUCTURAL BIOLOGY, WELLCOME TRUST CENTRE FOR HUMAN GENETICS, ROOSEVELT DRIVE, HEADINGTON, OXFORD, OX3 7BN

Grade 7: £31,076 - £38,183 p.a. (with a discretionary range to £41,709p.a.)                                                                                                                                                             

Applications are invited for two Postdoctoral Research Scientists in STRUBI to join Associate Professor Jonathan Grimes’s group in the Division of Structural Biology at the Wellcome Trust Centre for Human Genetics.

Associate Professor Grimes’s group incorporates structural biology and multidisciplinary bio-imaging approaches to characterize Influenza virus replication and transcription. Key to viral replication is the viral polymerase that copies the viral genome and produces viral messenger RNA which is then used to make building blocks for new virus particles.  Specifically, the group aims to understand in molecular level detail the mechanisms and dynamics of viral replication and transcription. Although strongly rooted in basic molecular biology research, the fundamental insights revealed from this work are aimed towards rational design of antivirals. 

You will have a PhD in structural biology, biochemistry, neuroscience or a related field with a research experience in either production of viral proteins for structure/function studies or Crystallization and X-ray crystallography, or single-particle cryo-electron microscopy, analysis of viruses or viral proteins. You will also have experience with multiple biophysical and cell-based assays, to validate structural information. You will also have an excellent publication record in a leading refereed journal, ability to manage the day-to-day running of a research project including assisting the work of junior researchers, good communication skills, and the ability to present work at international symposia and to non-specialist audiences.

The position is fixed term for three years and funded by Wellcome Trust.

To apply for this role and for further details, including a job description and person specification, please click on the link below:

http://www.ndm.ox.ac.uk/current-job-vacancies/vacancy/126664-Postdoctoral-Research-Scientists-on-a-BBSRC-Project-Grant-–-2-posts

Only applications received before 12:00 midday on Monday 6th February 2017 can be considered.

Please quote ref. 126664 on all correspondence. You will be required to upload a CV and supporting statement as part of your online application.

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UNIVERSITY OF OXFORD 
SENIOR BIOINFORMATICIAN - DIABETES AND INFLAMMATION LABORATORY
WELLCOME TRUST CENTRE FOR HUMAN GENETICS, ROOSEVELT DRIVE, HEADINGTON, OXFORD, OX3 7BN
Grade 8: £39,324 - £46,924 with a discretionary range to £51,260 p.a.

Applications are invited for the post of Senior Bioinformatician in the JDRF/Wellcome Trust Diabetes and Inflammation Laboratory (DIL).  The DIL relocated from Cambridge to the Wellcome Trust Centre for Human Genetics on 1 October 2016.

You will work alongside the Director, Professor John Todd, FRS, and the Co-Director, Professor Linda Wicker, to set up and manage the Genome informatics operations of the DIL in Oxford, in particular the maintenance and development of ImmunoBase: a community-wide tool for genetic, genomic and biological analyses of inflammatory diseases.  You will work closely with the DIL’s Programme Administrator, Head of Sample Processing and the Senior Data Manager.  You will have joint responsibility for the ongoing success of the research programme and will be a key ambassador for the DIL’s approach and mission.

Our interdisciplinary research programme – from disease gene discovery to translational clinical studies – involves national and international collaborations and funding agencies.  The DIL is a vibrant, enthusiastic, innovative and strategic enterprise in an internationally-leading position to make a real difference, not only to diabetes families in the future, but also to contributing significantly to basic knowledge of the disease process, and to develop and apply research methods and experimental medicine approaches. We have a fantastic track record of success and a reputation for a can-do attitude to tackling challenging research goals.  At the heart of the DIL is a deep commitment to training and career development of laboratory, computer and statistical scientists.

You will be responsible for all aspects of genomics projects, in particular the maintenance and development of our custom database, ImmunoBase.org. You will lead software development projects that supports the DIL and its collaborators, national and international.  You will be expected to manage and oversee the informatics requirements, the multiple research projects, set the overall software design principals, provide a considerable level of technical expertise to the projects, and will be responsible for selecting solutions and driving them through to practical realisation.

You will hold a PhD in a relevant subject area or have a strong track record of data management and programming in a scientific environment.  You will have project management experience of the planning, development, roll-out, and support of software systems.  The ability to communicate project plans and status to an extended team of stakeholders is essential.  A full list of the essential skills, attributes and experience can be found in the job description.

The post is available until 30 September 2020 in the first instance and is funded by the Wellcome Trust. 

To apply for this role and for further details, including a job description and person specification, please click on the link below:

http://www.ndm.ox.ac.uk/current-job-vacancies/vacancy/126970-Senior-Bioinformatician-in-DIL

Only applications received before 12pm, Monday 6 February 2017 can be considered. Please quote reference 126970 on all correspondence. Interviews will take place on 23 February 2017.

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UNIVERSITY OF OXFORD
POSTDOCTORAL RESEARCH SCIENTIST IN MALARIA VACCINE DEVELOPMENT
CENTRE FOR CELLULAR AND MOLECULAR PHYSIOLOGY, JENNER INSTITUTE, HENRY WELLCOME BUILDING FOR MOLECULAR PHYSIOLOGY, ROOSEVELT DRIVE, HEADINGTON, OXOFRD, OX3 7BN

Grade 7: Salary in the range £31,076 – £33,943 per annum

Applications are invited for a Postdoctoral Research Scientist in Malaria Vaccine Development at the Jenner Institute located at the Centre for Cellular and Molecular Physiology, Wellcome Trust Centre for Human Genetics.

You will work on the development of a Plasmodium vivax malaria vaccine, including pre-clinical, pre-GMP and liaising with external contractors for the GMP development. You will have a PhD degree in a relevant Biological Sciences or related subject and demonstrable experience in VLP and protein production and purification, particularly using the HepB S Antigen as a platform. This project consists on production of a VLP in Pichia, purification using AKTA systems and production of additional proteins suitable for assessment of antibody responses in a future clinical trial. You will also support other projects that are reaching GMP production and clinical trial stages, as well as some at an earlier stage of pre-clinical development.

You will be required to support the Principal Investigator and other senior, junior researchers and students in the day-to-day work of this project. You will supply information to the team and project manager to support tracking progress against objectives and compiling project reports in a timely manner for efficient running of the projects.

You will work closely with Prof. Arturo Reyes-Sandoval and his team and should be highly motivated, efficient, well-organised, pro-active, and able to take initiative and to work autonomously in a fast-paced, scientific environment, whilst reporting regularly to the Principal Investigator.

You will have a PhD in a relevant biological subject and significant proven experience in VLP production and GMP process development. You should have the ability to work independently and with own initiative whilst reporting regularly to Project Leader and project manager about work progress and assignment of priorities and resources with excellent interpersonal skills, including ability to form relationships with key stakeholders. You will have excellent verbal and written communication skills, including ability to communicate with people from multiple disciplines, particularly clinicians, scientists and bioinformaticians and excellent organisation skills, with the ability to prioritise tasks, adapt to changing demands and manage a complex workload of their own and that of other project members to work together to meet deadlines.

The post is fixed-term contract until 28 February 2018, with possibility of extension and funded by the Medical Research Council.

To apply for this role and for further details, including a job description and a person specification, please click on the link below:

http://www.ndm.ox.ac.uk/current-job-vacancies/vacancy/126929-Postdoctoral-Research-Scientist-in-Malaria-Vaccine-Development

Only applications received before 12:00 midday on Monday, 13 February 2017 will be considered.

Please quote reference 126929 on all correspondence. You will be required to upload a CV and supporting statement as part of your online application.

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UNIVERSITY OF OXFORD
BIOINFORMATICIAN IN PROSTATE CANCER
WELLCOME TRUST CENTRE FOR HUMAN GENETICS (MOVING TO BIG DATA INSTITUTE UPON COMPLETION IN EARLY 2017) ROOSEVELT DRIVE, HEADINGTON, OXOFRD, OX3 7BN

Grade 7: £31,076 - £38,183 with a discretionary range to £41,709 p.a.

THIS IS A READVERTISEMENT, PREVIOUS APPLICANTS NEED NOT APPLY. Applications are invited for a Bioinformatician in Prostate Cancer at the Big Data Institute under the supervision of Dr David Wedge currently based in the Wellcome Trust Centre for Human Genetics.

We are looking for a Bioinformatician in Prostate Cancer with interests in the fields of cancer genomics and bioinformatics. You will have extensive experience in the analysis of cancer genomics or other ‘big data’. The post is focused on the analysis of whole genome sequenced (WGS) data from more than 1200 prostate cancers. You will carry out the development of computational models, the statistical analysis of data and the scientific interpretation of data, as a member of a multi-disciplinary team.

You will have a PhD in a relevant subject (or MSc plus extensive practical experience); knowledge or interest in cancer biology / genetics; general bioinformatics skills; exemplary programming skills in R; experience of dealing with large datasets and highly developed problem solving and reasoning skills. You will also have excellent communication skills, ability to work both independently and as part of a multidisciplinary team with willingness to learn new techniques.

The post is fixed-term until 28th February 2019 with a possibility to extend to February 2020and funded by Cancer Research UK through the International Cancer Genome Consortium (ICGC).

To apply for this role and for further details, including a job description and person specification, please click on the link below:

http://www.ndm.ox.ac.uk/current-job-vacancies/vacancy/127210-Bioinformatician-in-Prostate-Cancer

Only applications received before 12:00, midday on Wednesday, 15th February 2017 can be considered.

Please quote reference 127210 on all correspondence. You will be required to make your application on-line and upload a supporting statement.

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