Senior Statistical Geneticist

Reedik_standardResearch Summary

My main interest is in implementing current statistical methods to computer software and developing new methods for association mapping. I am currently involved in several meta-analyses of various genome-wide association studies. I am also interested in studying homozygous regions of Human genome, CNVs and in application of these methods in association analyses. I have worked on several studies concerning linkage disequilibrium mapping of populations, population structure, marker selection and haplotype analysis. I am particularly interested in tagging SNP selection for association analysis and transferability of these tagging SNPs among populations.

Publication List

2010

Männik, K; Parkel, S; Palta, P; Žilina, O; Puusepp, H; Esko, T; Mägi, R; Nõukas, M;Veidenberg, A; Nelis, M; Metspalu, A; Remm, M; Õunap, K; Kurg, A. (2010). A Parallel SNP Array Study of Genomic Aberrations Associated With Mental Retardation in Patients and General Population in Estonia. European Journal of Medical Genetics. [in press]

Chaubey, Gyaneshwer; Metspalu, Mait; Choi, Ying; Mägi, Reedik; Gallego Romero, Irene; Soares, Pedro; van Oven, Mannis; Behar, Doron M; Rootsi, Siiri; Hudjashov, Georgi; Basu Mallick, Chandana; Karmin, Monika; Nelis, Mari; Parik, Jüri; Goverdhana Reddy, Alla; Metspalu, Ene; vanDriem, George; Xue, Yali; Tyler-Smith, Chris; Thangaraj, Kumarasamy; Singh, Lalji; Remm, Maido; Richards, Martin B; Mirazon Lahr, Marta; Kayser, Manfred; Villems, Richard; Kivisild, Toomas. (2010). Population Genetic Structure in Indian Austroasiatic speakers: The Role of Landscape Barriers and Sex-specific Admixture. Molecular Biology and Evolution. [in press]

Soranzo, Nicole; Sanna, Serena; Wheeler, Eleanor; Gieger, Christian; Radke, Dörte; Dupuis, Josée; Bouatia-Naji, Nabila; Langenberg, Claudia; Prokopenko, Inga; Stolerman, Elliot; Sandhu, Manjinder S; Heeney, Matthew M; Devaney, Joseph M; et al. (2010). Common variants at ten genomic loci influence hemoglobin A1C levels via glycemic and non-glycemic pathways. Diabetes. 59(12), 3229 - 3239.

Mägi, Reedik; Lindgren, Cecilia M.; Morris, Andrew P. (2010). Meta-analysis of sex-specific genome-wide association studies. Genetic Epidemiology. 34(8), 846 - 853.  PMID: 21104887

Lango Allen, Hana; Estrada, Karol; Lettre, Guillaume; Berndt, Sonja I; Weedon, Michael N; Rivadeneira, Fernando; Willer, Cristen J; Jackson, Anne U; Vedantam, Sailaja; Raychaudhuri, Soumya; Ferreira, Teresa; Wood, Andrew R; Weyant, Robert J; et al.(2010). Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature. 467(7317), 832 - 838.

Oitmaa, E.; Peters, M.; Vaidla, K.; Andreson, R.; Mägi, R.; Slavin, G.; Velthut, A.; Tõnisson, N.; Reimand, T.; Remm, M.; Schneider, M.; Õunap, K.; Salumets, A.; Metspalu, A. (2010). Molecular diagnosis of Down Syndrome using Quantitative APEX-2 microarrays. Prenatal Diagnosis. 30: 1170–1177.  PMID: 20949644

Heid, I.M.; Jackson, A.U.; Randall, J.C.; Winkler, T.W.; Qi, L.; Steinthorsdottir, V.; Thorleifsson, G.; Zillikens, M.C.; Speliotes, E.K.; Mägi, R.; et al. (2010). Meta analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution . Nature Genetics. 42(11), 949 - 960.  

Speliotes, E.K.; Willer, C.J.; Berndt, S.I.; Monda, K.L.; Thorleifsson, G.; Jackson, A.U.; Allen, H.L.; Lindgren, C.M.; Luan, J.; Mägi, R.; Randall, J.C.; Vedantam, S.; Winkler, T.W.; Workalemahu, T.; Heid, I.M.; Qi, L.; Steinthorsdottir, V.; et al. (2010). Genome-wide association study of 249,796 individuals reveals eighteen loci associated with body mass index. Nature Genetics. 42, 937 - 948.

Mägi, R; Morris, AP. (2010). GWAMA: software for genome-wide association meta-analysis. BMC Bioinformatics. 11(288).  PMID: 20509871

Ingelsson, E.; Langenberg, C.; Hivert, M.F.; Prokopenko, I.; Lyssenko, V.; Dupuis, J.; Mägi, R.; Sharp, S.; Jackson, A.U.; Assimes, T.L.; Shrader, P.; Knowles, J.W.; Zethelius, B.; et al. (2010). Detailed physiologic characterization reveals diverse mechanisms for novel genetic loci regulating glucose and insulin metabolism in humans. In: DIABETES: 59th Annual Meeting of the American-Society-of-Human-Genetics; Honolulu, HI, USA; OCT 20-24, 2009. 2010(5), 1266 - 1275.

Freathy, R.M.; Mook-Kanamori, D.O.; Sovio, U.; Prokopenko, I.; Timpson, N.J.; Berry, D.J.; Warrington, N.M.; Widen, E.; Hottenga, J.J.; Kaakinen, M.; Lange, L.A.; Bradfield, J.P.; Kerkhof, M.; Marsh, J.A.; Mägi, R.; et, al. (2010). Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. Nature Genetics. 42(5), 430 - 435.

Köttgen, A.; Pattaro, C.; Böger, C.A.; Fuchsberger, C.; Olden, M.; Glazer, N.L.; Parsa, A.; Gao, X.; Yang, Q.; Smith, A.V.; O'Connell, J.R.; et, al.; Mägi, R.; et, al. (2010). New loci associated with kidney function and chronic kidney disease. Nature Genetics. 42(5), 376 - 384.

Thorgeirsson, TE.; Gudbjartsson, DF.; Surakka, I.; Vink, JM.; Amin, N.; Geller, F.; Sulem, P.; Rafnar, T.; Esko, T.; Walter, S.; Gieger, C.; Rawal, R.; Mangino, M.; Prokopenko, I.; Mägi, R.; Keskitalo, K.; Gudjonsdottir, IH et al. Nature Genetics. 42(5), 448 - 453.

Dupuis, Josée; Langenberg, Claudia; Prokopenko, Inga; Saxena, Richa; Soranzo, Nicole; Jackson, Anne; Wheeler, Eleanor; Glazer, Nicole; Bouatia-Naji, Nabila; Gloyn, Anna; Lindgren, Cecilia; Mägi, Reedik; Morris, Andrew; Randall, Joshua; et al. (2010). New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nature Genetics. 42(2), 105 - 116.

2009

Nelis, M.; Esko, T.; Mägi, R.; Zimprich, F.; Zimprich, A.; Toncheva, D.; Karachanak, S.; Piskácková, T.; Balascák, I.; Peltonen, L.; Jakkula, E.; Rehnström, K.; Lathrop, M.; Heath, S.; Galan, P.; Schreiber, S.; Meitinger, T.; Pfeufer, A.; Wichmann, HE.; Melegh, B.; Polgár, N.; Toniolo, D.; Gasparini, P.; D'Adamo, P.; Klovins, J.; Nikitina-Zake, L.; Kucinskas, V.; Kasnauskiene, J.; Lubinski, J.; Debniak, T.; Limborska, S.; Khrunin, A.; Estivill, X.; Rabionet, R.; Marsal, S.; Julià, A.; Antonarakis, SE.; Deutsch, S.; Borel, C.; Attar, H.; Gagnebin, M.; Macek, M.; Krawczak, M.; Remm, M.; Metspalu, A. (2009). Genetic structure of Europeans: a view from the North-East. PLoS ONE. 4(5), e5472.  PMID: 19424496

2008

Krjutskov, K.; Andreson, R.; Mägi, R.; Nikopensius, T.; Khrunin, A.; Mihailov, E.; Tammekivi, V.; Sork, H.; Remm, M.; Metspalu, A. (2008). Development of a single tube 640-plex genotyping method for detection of nucleic acid variations on microarrays. Nucleic Acids Research. 36(12), e75. PMID: 18539607

Tamm, R.; Oselin, K.; Kallassalu, K.; Mägi, R.; Anier, K.; Remm, M.; Metspalu, A. (2008). Thiopurine S-methyltransferase (TPMT) pharmacogenetics: three new mutations and haplotype analysis in the Estonian population. Clinical Chemistry and Laboratory Medicine. 46(7), 974 - 979. PMID: 18605963

2007

Mägi, R.; Pfeufer, A.; Nelis, M.; Montpetit, A.; Metspalu, A.; Remm, M. (2007). Evaluating the performance of commercial whole-genome marker sets for capturing common genetic variation. BMC Genomics. 8(159), x. PMID: 17562002

Kuningas, M.; Mägi, R.; Westendorp, R.G.; Slagboom, P.E.; Remm, M.; van Heemst, D. (2007). Haplotypes in the human Foxo1a and Foxo3a genes; impact on disease and mortality at old age. (2007).  European Journal of Human Genetics. 15(3), 294 - 301. PMID: 17245409

2006

Montpetit, A.; Nelis, M.; Laflamme, P.; Mägi, R.; Ke, X.Y.; Remm, M.; Cardon, L.; Hudson, T.J.; Metspalu, A. (2006). An evaluation of the performance of tag SNPs derived from HapMap in a Caucasian population . PLOS GENETICS, 2(3), 282 - 290. PMID: 16532062

Mägi, R.; Kaplinski, L.; Remm, M. (2006). The Whole Genome TagSNP Selection and Transferability Among HapMap Populations. In: Pacific Symposium on Biocomputing 2006: 2006. World Scientific Publ Co Pte Ltd. 2006, 535 - 543. PMID: 17094267

2005

Mueller, J. C.; Lõhmussaar, E.; Mägi, R.; Remm, M.; Bettecken, T.; Lichtner, P.; Huber, S.; Illig, T; Luedemann, J.; Schreiber, S.; Wichmann, H. E.; Pramstaller, P.; Romeo, G.; Testa, A.; Metspalu, A.; Meitinger, T. (2005). Linkage Disequilibrium Patterns and tagSNP Transferability among European Populations. American Journal of Human Genetics. 76(3), 387 - 398. PMID: 15637659

2002

Dawson, E.; Abecasis, GR.; Bumpstead, S.; Chen, Y.; Hunt, S.; Beare, DM.; Pabial, J.; Dibling, T.; Tinsley, E.; Kirby, S.; Carter, D.; Papaspyridonos, M.; Livingstone, S.; Ganske, R.; Lohmmussaar, E.; Zernant, J.; Tonisson, N.; Remm, M.; Mägi, R.; Puurand, T.; Vilo, J.; Kurg, A.; Rice, K.; Deloukas, P.; Mott, R.; Metspalu, A.; Bentley, D.R.; Cardon, L.R.; Dunham, I. (2002). A first-generation linkage disequilibrium map of human chromosome 22. Nature. 418(6897), 544 - 548. PMID: 12110843

Research Areas

Statistical genetics and population genetics

Keywords

Association analysis, population genetics

Contact Details

Wellcome Trust Centre for Human Genetics
University of Oxford
Roosevelt Drive
Oxford; OX3 7BN; UK

email: reedik@well.ox.ac.uk

tel: +44 (0)1865 287829

fax: +44 (0)1865 287664