Selected recent publications

Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study. Davenport EE, Burnham KL, Radhakrishnan J, Humburg P, Hutton P, Mills TC, Rautanen A, Gordon AC, Garrard C, Hill AV, Hinds CJ, Knight JC. Lancet Respir Med. 2016 Feb 22. pii: S2213-2600(16)00046-1.

Killer-cell-Immunoglobulin-like Receptor (KIR) gene profiles modify HIV disease course, not HIV acquisition in South African women. Naranbhai V, de Assess Rosa D, Werner L, Moodley R, Hong H, Kharsany A, Mlisana K, Sibeko S, Garrett N, Chopera D, Carr WHC, Abdool Karim Q, Hill AVS, Abdool Karim SS, Altfeld M, Gray C, Ndungu T.BMC Infect Dis. 2016 Jan 25;16(1):27.

Variants in the Mannose-binding Lectin Gene MBL2 do not Associate With Sepsis Susceptibility or Survival in a Large European Cohort. Mills TC, Chapman S, Hutton P, Gordon AC, Bion J, Chiche JD, Holloway PA, Stüber F, Garrard CS, Hinds CJ, Hill AV, Rautanen A; ESICM/ECCRN GenOSept Investigators. Clin Infect Dis. 2015 Sep 1;61(5):695-703.

Genetic susceptibility to invasive Salmonella disease. Gilchrist JJ, MacLennan CA, Hill AV. Nat Rev Immunol. 2015 Jul;15(7):452-63. doi: 10.1038/nri3858.

Searching for the human genetic factors standing in the way of universally effective vaccines. Mentzer AJ, O'Connor D, Pollard AJ, Hill AV. Philos Trans R Soc Lond B Biol Sci. 2015 Jun 19;370(1671)

Rare variants in MYD88, IRAK4 and IKBKG and susceptibility to invasive pneumococcal disease: a population-based case-control study. Ellis MK, Elliott KS, Rautanen A, Crook DW, Hill AV, Chapman SJ. PLoS One. 2015 Apr 17;10(4):e0123532.

Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study. Rautanen A, Mills TC, Gordon AC, Hutton P, Steffens M, Nuamah R, Chiche JD, Parks T, Chapman SJ, Davenport EE, Elliott KS, Bion J, Lichtner P, Meitinger T, Wienker TF, Caulfield MJ, Mein C, Bloos F, Bobek I, Cotogni P, Sramek V, Sarapuu S, Kobilay M, Ranieri VM, Rello J, Sirgo G, Weiss YG, Russwurm S, Schneider EM, Reinhart K, Holloway PA, Knight JC, Garrard CS, Russell JA, Walley KR, Stüber F, Hill AV, Hinds CJ; ESICM/ECCRN GenOSept Investigators. Lancet Respir Med. 2015 Jan;3(1):53-60.

Distinct transcriptional and anti-mycobacterial profiles of peripheral blood monocytes dependent on the ratio of monocytes:lymphocytes. Naranbhai V, Fletcher HA, Tanner R, O’Shea M, McShane H, Fairfax BP, Knight JC, Hill AVS. EBiomedicine. 2015 Sep 24;2(11):1619-1626.

Genomic modulators of gene expression in human neutrophils. Naranbhai V, Fairfax BP, Makino S, Humburg P, Wong D, Ng E, Hill AV, Knight JC. Nat Commun. 2015 Jul 7;6:7545.

The association between the ratio of monocytes: lymphocytes and risk of tuberculosis among HIV-infected postpartum women. Naranbhai V, Moodley D, Chipato T, Stranix-Chibanda L, Nakabaiito C, Kamateeka M, Musoke P, Manji K, George K, Emel LM, Richardson P, Andrew P, Fowler M, Fletcher H, McShane H, Coovadia HM, Hill AV; HPTN 046 Protocol Team. J Acquir Immune Defic Syndr. 2014 Dec 15;67(5):573-5.

The association between the ratio of monocytes:lymphocytes at age 3 months and risk of tuberculosis (TB) in the first two years of life. Naranbhai V, Kim S, Fletcher H, Cotton MF, Violari A, Mitchell C, Nachman S, McSherry G, McShane H, Hill AV, Madhi SA.
12. BMC Med. 2014 Jul 17;12:120.

Ratio of monocytes to lymphocytes in peripheral blood identifies adults at risk of incident tuberculosis among HIV-infected adults initiating antiretroviral therapy. Naranbhai V, Hill AV, Abdool Karim SS, Naidoo K, Abdool Karim Q, Warimwe GM, McShane H, Fletcher H. J Infect Dis. 2014 Feb 15;209(4):500-9.

Mills TC, Rautanen A, Elliott KS, Parks T, Naranbhai V, Ieven MM, Butler CC, Little P, Verheij T, Garrard CS, Hinds C, Goossens H, Chapman S, Hill AV. IFITM3 and susceptibility to respiratory viral infections in the community. J Infect Dis. 2014 Apr 1;209(7):1028-31. PMID: 23997235

Bowdish DM, Sakamoto K, Lack NA, Hill PC, Sirugo G, Newport MJ, Gordon S, Hill AV, Vannberg FO. Genetic variants of MARCO are associated with susceptibility to pulmonary tuberculosis in a Gambian population. BMC Med Genet. 2013 Apr 23;14:47. PMID: 23617307

Grossman SR, Andersen KG, Shlyakhter I, Tabrizi S, Winnicki S, Yen A, Park DJ, Griesemer D, Karlsson EK, Wong SH, Cabili M, Adegbola RA, Bamezai RN, Hill AV, Vannberg FO, Rinn JL; 1000 Genomes Project, Lander ES, Schaffner SF, Sabeti PC. Identifying recent adaptations in large-scale genomic data. Cell. 2013 Feb 14;152(4):703-13. PMID: 23415221

Parks T, Hill AV, Chapman SJ. The perpetual challenge of infectious diseases. N Engl J Med. 2012 Jul 5;367(1):90; author reply 90. PMID: 22762339

Hill AV. Evolution, revolution and heresy in the genetics of infectious disease susceptibility. Philos Trans R Soc Lond B Biol Sci. 2012 Mar 19;367(1590):840-9. PMID: 22312051

Chapman SJ, Hill AV. Human genetic susceptibility to infectious disease. Nat Rev Genet. 2012 Feb 7;13(3):175-88. PMID: 22310894

Thye T, Owusu-Dabo E, Vannberg FO, van Crevel R, Curtis J, Sahiratmadja E, Balabanova Y, Ehmen C, Muntau B, Ruge G, Sievertsen J, Gyapong J, Nikolayevskyy V, Hill PC, Sirugo G, Drobniewski F, van de Vosse E, Newport M, Alisjahbana B, Nejentsev S, Ottenhoff TH, Hill AV, Horstmann RD, Meyer CG. Common variants at 11p13 are associated with susceptibility to tuberculosis. Nat Genet. 2012 Feb 5;44(3):257-9. PMID: 22306650

Vannberg FO, Chapman SJ, Hill AV. Human genetic susceptibility to intracellular pathogens. Immunol Rev. 2011 Mar;240(1):105-16. PMID: 21349089

Chapman SJ, Khor CC, Vannberg FO, Rautanen A, Walley A, Segal S, Moore CE, Davies RJ, Day NP, Peshu N, Crook DW, Berkley JA, Williams TN, Scott JA, Hill AV. Common NFKBIL2 polymorphisms and susceptibility to pneumococcal disease: a genetic association study. Crit Care. 2010;14(6):R227. PMID:21171993

George J, Motshwene PG, Wang H, Kubarenko AV, Rautanen A, Mills TC, Hill AV, Gay NJ, Weber AN. Two human MYD88 variants, S34Y and R98C, interfere with MyD88-IRAK4-myddosome assembly. J Biol Chem. 2011 Jan 14;286(2):1341-53. PMID: 20966070

Kubarenko AV, Ranjan S, Rautanen A, Mills TC, Wong S, Vannberg F, Neumaier M, Bekeredjian-Ding I, Hill AV, Ahmad-Nejad P, Weber AN. A naturally occurring variant in human TLR9, P99L, is associated with loss of CpG oligonucleotide responsiveness. J Biol Chem. 2010 Nov 19;285(47):36486-94. PMID: 20843814

Thye T, Vannberg FO, Wong SH, Owusu-Dabo E, Osei I, Gyapong J, Sirugo G, Sisay-Joof F, Enimil A, Chinbuah MA, Floyd S, Warndorff DK, Sichali L, Malema S, Crampin AC, Ngwira B, Teo YY, Small K, Rockett K, Kwiatkowski D, Fine PE, Hill PC, Newport M, Lienhardt C, Adegbola RA, Corrah T, Ziegler A; African TB Genetics Consortium; Wellcome Trust Case Control Consortium, Morris AP, Meyer CG, Horstmann RD, Hill AV. Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2. Nat Genet. 2010 Sep;42(9):739-41. PMID:20694014

Wong SH, Gochhait S, Malhotra D, Pettersson FH, Teo YY, Khor CC, Rautanen A, Chapman SJ, Mills TC, Srivastava A, Rudko A, Freidin MB, Puzyrev VP, Ali S, Aggarwal S, Chopra R, Reddy BS, Garg VK, Roy S, Meisner S, Hazra SK, Saha B, Floyd S, Keating BJ, Kim C, Fairfax BP, Knight JC, Hill PC, Adegbola RA, Hakonarson H, Fine PE, Pitchappan RM, Bamezai RN, Hill AV, Vannberg FO. Leprosy and the adaptation of human toll-like receptor 1. PLoS Pathog. 2010 Jul 1;6:e1000979. PMID: 20617178

Khor CC, Vannberg FO, Chapman SJ, Guo H, Wong SH, Walley AJ, Vukcevic D, Rautanen A, Mills TC, Chang KC, Kam KM, Crampin AC, Ngwira B, Leung CC, Tam CM, Chan CY, Sung JJ, Yew WW, Toh KY, Tay SK, Kwiatkowski D, Lienhardt C, Hien TT, Day NP, Peshu N, Marsh K, Maitland K, Scott JA, Williams TN, Berkley JA, Floyd S, Tang NL, Fine PE, Goh DL, Hill AV. CISH and susceptibility to infectious diseases. N Engl J Med. 2010 Jun 3;362(22):2092-101. PMID:20484391

Wong SH, Hill AV, Vannberg FO; India-Africa-United Kingdom Leprosy Genetics Consortium. Genomewide association study of leprosy. N Engl J Med. 2010 Apr 15;362(15):1446-7; author reply 1447-8. PMID: 20393182

Chapman SJ, Vannberg FO, Khor CC, Rautanen A, Maskell NA, Davies CW, Moore CE, Day NP, Crook DW, Davies RJ, Hill AV. Mannose-binding lectin genotypes: lack of association with susceptibility to thoracic empyema. BMC Med Genet. 2010 Jan 15;11:5.PMID: 20078874

Lyons EJ, Amos W, Berkley JA, Mwangi I, Shafi M, Williams TN, Newton CR, Peshu N, Marsh K, Scott JA, Hill AV. Homozygosity and risk of childhood death due to invasive bacterial disease. BMC Med Genet. 2009 Jun 12;10:55.PMID:19523202   

Chapman SJ, Khor CC, Vannberg FO, Rautanen A, Segal S, Moore CE, Davies RJ, Day NP, Peshu N, Crook DW, Berkley JA, Williams TN, Scott JA, Hill AV. NFKBIZ polymorphisms and susceptibility to pneumococcal disease in European and African populations. Genes Immun. 2010 Jun;11(4):319-25. Epub 2009 Oct 1. PMID: 19798075

Vannberg FO, Chapman SJ, Khor CC, Tosh K, Floyd S, Jackson-Sillah D, Crampin A, Sichali L, Bah B, Gustafson P, Aaby P, McAdam KP, Bah-Sow O, Lienhardt C,Sirugo G, Fine P, Hill AV. CD209 genetic polymorphism and tuberculosis disease.PLoS ONE. 2008 Jan 2;3(1):e1388.PMID: 18167547 

Hennig BJ, Fielding K, Broxholme J, Diatta M, Mendy M, Moore C, Pollard AJ,Rayco-Solon P, Sirugo G, van der Sande MA, Waight P, Whittle HC, Zaman SM, Hill AV, Hall AJ. Host genetic factors and vaccine-induced immunity to hepatitis B virus infection.PLoS ONE. 2008 Mar 26;3(3):e1898.PMID: 18365030

Cooke GS, Campbell SJ, Bennett S, Lienhardt C, McAdam KP, Sirugo G, Sow O,Gustafson P, Mwangulu F, van Helden P, Fine P, Hoal EG, Hill AV. Mapping of a novel susceptibility locus suggests a role for MC3R and CTSZ inhuman tuberculosis. Am J Respir Crit Care Med. 2008 Jul 15;178(2):203-7. PMID: 18420963

Khor CC, Vannberg FO, Chapman SJ, Walley A, Aucan C, Loke H, White NJ, Peto T,Khor LK, Kwiatkowski D, Day N, Scott A, Berkley JA, Marsh K, Peshu N, Maitland K,Williams TN, Hill AV. Positive replication and linkage disequilibrium mapping of the chromosome 21q22.1 malaria susceptibility locus. Genes Immun. 2007 Oct;8(7):570-6. PMID: 17703179

Chapman SJ, Khor CC, Vannberg FO, Frodsham A, Walley A, Maskell NA, Davies CW, Segal S, Moore CE, Gillespie SH, Denny P, Day NP, Crook DW, Davies RJ, Hill AV. IkappaB genetic polymorphisms and invasive pneumococcal disease. Am J Respir Crit Care Med. 2007 Jul 15;176(2):181-7. PMID: 17463416

Khor CC, Chapman SJ, Vannberg FO, Dunne A, Murphy C, Ling EY, Frodsham AJ, Walley AJ, Kyrieleis O, Khan A, Aucan C, Segal S, Moore CE, Knox K, Campbell SJ, Lienhardt C, Scott A, Aaby P, Sow OY, Grignani RT, Sillah J, Sirugo G, Peshu N, Williams TN, Maitland K, Davies RJ, Kwiatkowski DP, Day NP, Yala D, Crook DW, Marsh K, Berkley JA, O'Neill LA, Hill AV. A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis. Nat Genet. 2007 Apr;39(4):523-8. PMID: 17322885

Chapman SJ, Khor CC, Vannberg FO, Maskell NA, Davies CW, Hedley EL, Segal S, Moore CE, Knox K, Day NP, Gillespie SH, Crook DW, Davies RJ, Hill AV. PTPN22 and invasive bacterial disease. Nat Genet. 2006 May;38(5):499-500. PMID: 16642008

Roy S Knox K, Segal S, Griffiths D, Moore CE, Welsh KI, Smarason A, Day NP, McPheat WL, Crook DW, Hill AV, and the Oxford Pneumococcal Surveillance Group. MBL genotype and risk of invasive pneumococcal disease: a case-control study. Lancet 2002; 359: 1569-73. PMID: 12047967

Roy S, Knox K, Griffiths D, Crook D, Hill AVS. C reactive protein polymorphism is associated with susceptibility to invasive pneumococcal disease. BMJ 2002; 324: 1369. PMID: 12052806