Dyslexia

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Publications

2011

DCDC2, KIAA0319 and CMIP Are Associated with Reading-Related Traits. (2011) Scerri TS, Morris AP, Buckingham LL, Newbury DF, Miller LL, Monaco AP, Bishop DV, Paracchini S. Biol Psychiatry. Mar 30. PMID: 21457949 [Epub ahead of print]

  

2010

Investigation of Dyslexia and SLI Risk Variants in Reading- and Language-Impaired Subjects. (2010) Newbury DF, Paracchini S, Scerri TS, Winchester L, Addis L, Richardson AJ, Walter J, Stein JF, Talcott JB, Monaco AP. Behav Genet. Dec 17. PMID: 21165691 [Epub ahead of print]

PCSK6 is associated with handedness in individuals with dyslexia. (2010) Scerri TS, Brandler WM, Paracchini S, Morris AP, Ring SM, Talcott JB, Stein J, Monaco AP. Hum Mol Genet. Nov 9. PMID: 21051773 [Epub ahead of print] 

Identification of candidate genes for dyslexia susceptibility on chromosome 18. Scerri TS, Paracchini S, Morris A, MacPhie IL, Talcott J, Stein J, Smith SD, Pennington BF, Olson RK, DeFries JC, Monaco AP. PLoS One. 2010 Oct 28;5(10):e13712. PMID: 21060895 [Epub ahead of print] 

The dyslexia-associated KIAA0319 protein undergoes proteolytic processing with {gamma}-secretase-independent intramembrane cleavage (2010) Velayos-Baeza A, Levecque C, Kobayashi K, Holloway ZG, Monaco AP. J Biol Chem.  Oct 13 [Epub ahead of print] 

An Allele-specific Gene Expression Assay to test the Functional Basis of Genetic Associations. Paracchini S, Monaco AP, and Knight JC. (2010)  Journal of Visualized Experiments. Nov 3;(45). pii: 2279. doi: 10.3791/2279. PMID: 21085102 [Open access]  

Analysis of dyslexia candidate genes in the Raine cohort representing the general Australian population. (2010) Paracchini S, Ang QW, Stanley FJ, Monaco AP, Pennell CE, and Whitehouse AJO. Genes, Brain and Behavior. Sep 16. doi: 10.1111/j.1601-183X.2010.00651.x. [Epub ahead of print]

 

2009

Genetics of Developmental Dyslexia.(2009)
Scerri TS, Schulte-Körne, G. European Child and Adolescent Psychiatry. November online  

The dyslexia-associated protein KIAA0319 interacts with Adaptor Protein 2 and follows the classical clathrin-mediated endocytosis pathway.
Levecque C, Velayos-Baeza A, Holloway ZG, Monaco AP.
In Am J Physiol Cell Physiol. 2009 May 6. [Epub ahead of print] [PMID: 19419997] [Open Access pdf]

A Common Variant Associated with Dyslexia Reduces Expression of the KIAA0319 Gene
Megan Y. Dennis, Silvia Paracchini, Thomas S. Scerri, Ludmila Prokunina-Olsson, Julian C. Knight, Richard Wade-Martins, Penny Coggill, Stephan Beck, Eric D. Green, Anthony P. Monaco.
In PLOS Genetics March 2009 vol 5(3). [Link to full article (open access pdf)]

2008

Association of the KIAA0319 Dyslexia Susceptibility Gene With Reading Skills in the General Population (2008)
Silvia Paracchini, Colin D. Steer, Lyn-Louise Buckingham, Andrew P. Morris, Susan Ring, Thomas Scerri, John Stein, Marcus E. Pembrey, Jiannis Ragoussis, Jean Golding, and Anthony P. Monaco.
Am J Psychiatry: Advanced online publication.  Published October 1, 2008 doi: 10.1176/appi.ajp.2008.07121872

2007 

The Dyslexia-Associated Gene KIAA0319 encodes highly N- and O-Glycosylated plasma mebrane and secreted isoform (2007)
Antonio Velayos-Baeza, Claudio Toma, Silvia Paracchini, Anthony P. Monaco.
Human Molecular Genetics: Advanced online publication.
[Full article] [PubMed record] 

The Genetic Lexicon of Dyslexia (2007)

Silvia Paracchini, Thomas Scerri, Anthony P. Monaco.
Annual Review of Genomics and Human Genetics: 8. September 2007
[Full article] [PubMed record] 

Alternative splicing in the dyslexia-associated gene KIAA0319. (2007)

Antonio Velayos-Baeza, Claudio Toma, Stephanie da Roza, Silvia Paracchini, Anthony P. Monaco.
Mammalian Genome: Online first, September 2007.
[Abstract] [PubMed record]

2006

The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronal migration (2006)
Silvia Paracchini, Ankur Thomas, Sandra Castro, Cecilia Lai, Murugan Paramasivam, Yu Wang, Brendan J. Keating, Jennifer M. Taylor, Douglas F. Hacking, Thomas Scerri, Clyde Francks, Alex J. Richardson, Richard Wade-Martins, John F. Stein, Julian C. Knight, Andrew J. Copp, Joseph LoTurco and Anthony P. Monaco.
Human Molecular Genetics. 15: 10 1659-1666
[Full article] [PubMed record]

Further evidence that the KIAA0319 gene confers susceptibility to developmental dyslexia. (2006)
Harold D*, Paracchini S*, Scerri T, Dennis M, Cope N, Hill G, Moskvina V,  Walter J, Richardson AJ, Owen MJ, Stein JF, Green ED, O'Donovan MC, Williams J, Monaco AP.
*Joint authorship.
Mol Psychiatry. 11(12):1085-1091.
[PubMed record]

Pre 2006

Francks C*, Paracchini S*, Smith SD, Richardson AJ, Scerri TS, Cardon LR, Marlow AJ, Macphie IL, Walter J, Pennington BF, Fisher SE, Olson RK, Defries JC, Stein JF, Monaco AP (2004) 
A 77-kilobase region of chromosome 6p22.2 is associated with dyslexia in families from the United kingdom and from the United States.
Am. J. Hum. Genet. 75: 1046-1058 *joint first authors 
[Pubmed record]

Scerri TS, Fisher SE, Francks C, MacPhie IL, Paracchini S, Richardson AJ, Stein JF, Monaco AP. (2004)
Putative functional alleles of DYX1C1 are not associated with dyslexia susceptibility in a large sample of sibling pairs from the UK.
J. Med. Genet.  41: 853-857 [Pubmed record] [Full article] [pdf from journal website]

Francks C, Fisher SE, Marlow AJ, MacPhie IL, Taylor KE, Richardson AJ, Stein JF, Monaco AP. (2003)
Familial and genetic effects on motor coordination, laterality, and reading-related cognition.
Am J Psych 160: 1970-1977 [Abstract] [pdf from journal website]

Marlow AJ, Fisher SE, Francks C, MacPhie IL, Richardson AJ, Talcott JB, Stein JF, Monaco AP & Cardon LR. (2003)
Use of multivariate linkage analysis for dissection of a complex cognitive trait.
Am J Hum Genet 72: 561-570 [Abstract]

Fisher SE*, Francks C*, Marlow AJ, MacPhie IL, Newbury DF, Cardon LR, Ishikawa-Brush Y, Richardson AJ, Talcott JB, Gayán J, Olson RK, Pennington BF, Smith SD, DeFries JC, Stein JF & Monaco AP. (2002)
Independent genome-wide scans identify a chromosome 18 quantitative-trait locus influencing dyslexia.
Nature Genet 30: 86-91*joint first authors [abstract] [pdf from journal website]

Fisher SE & DeFries JC. (2002)
Developmental dyslexia: genetic dissection of a complex cognitive trait.
Nature Rev Neurosci 3: 767-780

Francks C, Fisher SE, Olson RK, Pennington BF, Smith SD, DeFries JC & Monaco AP (2002).
Quantitative association analysis within the chromosome 2p12-16 dyslexia susceptibility region: Microsatellite markers and candidate genes SEMA4F and OTX1.
Psych Genet 12: 35-41 [abstract] [journal website]

Francks C, MacPhie IL & Monaco AP. (2002)
The genetic basis of dyslexia.  
Lancet Neurol 1: 483-490

Fisher SE & Smith SD (2001)
Progress towards the identification of genes influencing developmental dyslexia.
In Dyslexia: Theory and good practice (ed. Fawcett AJ) 39-64 (Whurr, London, UK) [Book information from Blackwell's]

Marlow AJ, Fisher SE, Richardson AJ, Francks C, Talcott JB, Monaco AP, Stein JF & Cardon LR. (2001)
Investigation of quantitative measures related to reading disability in a large sample of sib-pairs from the UK.
Behav Genet 31:219-230 [abstract]

Francks C, Fisher SE, Marlow AJ, Richardson AJ, Stein JF & Monaco AP. (2000)
A sibling-pair based approach for mapping genetic loci that influence quantitative measures of reading disability.
Prostaglandins, Leukotrienes & Essential Fatty Acids 63:27-31 [abstract]

Fisher SE, Marlow AJ, Lamb J, Maestrini E, Williams DF, Richardson AJ, Weeks DE, Stein JF & Monaco AP. (1999)
A quantitative trait locus on chromosome 6p influences different aspects of developmental dyslexia.
Am J Hum Genet 64:146-156 [abstract]

Fisher SE, Stein JF & Monaco AP. (1999)
A genome-wide search strategy for identifying quantitative trait loci involved in reading and spelling disability (developmental dyslexia).
Eur Child & Adolescent Psych  8(S3):47-51 [abstract]