Chapman group publications

Selected Publications

Cuella-Martin R, Oliveira C, Lockstone H, Snellenberg S, Gromulsova N, Chapman JR (2016). 53BP1 Integrates DNA Repair and p53-Dependent Cell Fate Decisions via Distinct Mechanisms. Molecular Cell, 64(1):51-64.

Xu, G., Chapman, J.R., Brandsma, I., Yuan, J., Mistrik, M., Bouwman, P., Bartkova, J. et al. (2015). REV7 counteracts DNA double-strand break resection and affects PARP inhibitionNature, 521(7553):541–4.

Figure 3 website
RIF1-deficiency in mice results in aberrant nucleolytic processing of DSBs during immunoglobulin class-switch recombination. Chromatin immunoprecipitation of the single stranded DNA binding protein RPA32 at Immunoglobulin heavy chain (IgH) and control (Rpp30) loci in stimulated primary B-cells.

Chapman, J. R., Barral, P., Vannier, J.-B., Borel, V., Steger, M., Tomas-Loba, A., et al. (2013). RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection. Molecular Cell, 49(5), 858–871.

Chapman, J. R., Sossick, A. J., Boulton, S. J., & Jackson, S. P. (2012). BRCA1-associated exclusion of 53BP1 from DNA damage sites underlies temporal control of DNA repair. Journal of Cell Science, 125(Pt 15), 3529–3534.

Polo, S. E.*, Blackford, A. N.*, Chapman, J. R., Baskcomb, L., Gravel, S., Rusch, A., et al. (2012). Regulation of DNA-end resection by hnRNPU-like proteins promotes DNA double-strand break signaling and repair. Molecular Cell, 45(4), 505–516. (*equal contribution)

Lloyd, J*., Chapman, J. R*., Clapperton, J. A.*, Haire, L. F., Hartsuiker, E., Li, J., et al. (2009). A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage. Cell, 139(1), 100–111. (*equal contribution)

Chapman, J. R., & Jackson, S. P. (2008). Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage. EMBO reports, 9(8), 795–801.

Gravel, S., Chapman, J. R., Magill, C., & Jackson, S. P. (2008). DNA helicases Sgs1 and BLM promote DNA double-strand break resection. Genes & Development, 22(20), 2767–2772.

Kolas, N. K.*, Chapman, J. R.*, Nakada, S.*, Ylanko, J., Chahwan, R., Sweeney, F. D., et al. (2007). Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase. Science, 318(5856), 1637–1640. (*equal contribution)

Jones, R. E., Chapman, J. R., Puligilla, C., Murray, J. M., Car, A. M., Ford, C. C., & Lindsay, H. D. (2003). XRad17 is required for the activation of XChk1 but not XCds1 during checkpoint signaling in Xenopus. Molecular biology of the cell, 14(9), 3898–3910.

Reviews

Chapman, J. R., Taylor, M. R. G., & Boulton, S. J. (2012). Playing the end game: DNA double-strand break repair pathway choice. Molecular Cell, 47(4), 497–510.