Publications

Irshad, S. et al. BMP and Notch interaction in CRC subtypes. J Pathol, doi:10.1002/path.4891 (2017).

Cheng, T. H. et al. Five endometrial cancer risk loci identified through genome-wide association analysis. Nat Genet 48, 667-674, doi:10.1038/ng.3562 (2016).

Davis, H. et al. Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche. Nat Med 21, 62-70, doi:10.1038/nm.3750 (2015).

Lewis, A. et al. A polymorphic enhancer near GREM1 influences bowel cancer risk through differential CDX2 and TCF7L2 binding. Cell Rep 8, 983-990, doi:10.1016/j.celrep.2014.07.020 (2014).

Davis, H., Lewis, A., Behrens, A. & Tomlinson, I. Investigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines. Gut 63, 792-799, doi:10.1136/gutjnl-2013-304719 (2014).

Leedham, S. J. et al. A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts. Gut 62, 83-93, doi:10.1136/gutjnl-2011-301601 (2013).

Lewis, A. & Tomlinson, I. Cancer. The utility of mouse models in post-GWAS research. Science 338, 1301-1302, doi:10.1126/science.1231733 (2012).

Lewis, A. et al. The C-terminus of Apc does not influence intestinal adenoma development or progression. J Pathol 226, 73-83, doi:10.1002/path.2972 (2012).

Jaeger, E. et al. Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1. Nat Genet 44, 699-703, doi:10.1038/ng.2263 (2012).

Tomlinson, I. P. et al. Multiple common susceptibility variants near BMP pathway loci GREM1, BMP4, and BMP2 explain part of the missing heritability of colorectal cancer. PLoS Genet 7, e1002105, doi:10.1371/journal.pgen.1002105 (2011).

Davis, H. et al. FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development. J Pathol 224, 180-189, doi:10.1002/path.2874 (2011).

Babaei-Jadidi, R. et al. FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation. J Exp Med 208, 295-312, doi:10.1084/jem.20100830 (2011).

Lewis, A. et al. Severe polyposis in Apc(1322T) mice is associated with submaximal Wnt signalling and increased expression of the stem cell marker Lgr5. Gut 59, 1680-1686, doi:10.1136/gut.2009.193680 (2010).

Redrup, L. et al. The long noncoding RNA Kcnq1ot1 organises a lineage-specific nuclear domain for epigenetic gene silencing. Development 136, 525-530, doi:10.1242/dev.031328 (2009).

Pollard, P. et al. The Apc 1322T mouse develops severe polyposis associated with submaximal nuclear beta-catenin expression. Gastroenterology 136, 2204-2213 e2201-2213, doi:10.1053/j.gastro.2009.02.058 (2009).

Green, K. et al. A developmental window of opportunity for imprinted gene silencing mediated by DNA methylation and the Kcnq1ot1 noncoding RNA. Mamm Genome 18, 32-42, doi:10.1007/s00335-006-0092-9 (2007).

Lewis, A. & Reik, W. How imprinting centres work. Cytogenet Genome Res 113, 81-89, doi:10.1159/000090818 (2006).

Lewis, A. et al. Epigenetic dynamics of the Kcnq1 imprinted domain in the early embryo. Development 133, 4203-4210, doi:10.1242/dev.02612 (2006).

Reik, W. & Lewis, A. Co-evolution of X-chromosome inactivation and imprinting in mammals. Nat Rev Genet 6, 403-410, doi:10.1038/nrg1602 (2005).

Reik, W. et al. Chromosome loops, insulators, and histone methylation: new insights into regulation of imprinting in clusters. Cold Spring Harb Symp Quant Biol 69, 29-37, doi:10.1101/sqb.2004.69.29 (2004).

Lewis, A. & Murrell, A. Genomic imprinting: CTCF protects the boundaries. Curr Biol 14, R284-286, doi:10.1016/j.cub.2004.03.026 (2004).

Lewis, A. et al. Imprinting on distal chromosome 7 in the placenta involves repressive histone methylation independent of DNA methylation. Nat Genet 36, 1291-1295, doi:10.1038/ng1468 (2004).

Lewis, A., Mitsuya, K., Constancia, M. & Reik, W. Tandem repeat hypothesis in imprinting: deletion of a conserved direct repeat element upstream of H19 has no effect on imprinting in the Igf2-H19 region. Mol Cell Biol 24, 5650-5656, doi:10.1128/MCB.24.13.5650-5656.2004 (2004).

Lopes, S. et al. Epigenetic modifications in an imprinting cluster are controlled by a hierarchy of DMRs suggesting long-range chromatin interactions. Hum Mol Genet 12, 295-305 (2003).