Julian Knight Group
List of Publications
2013
Knight JC. 2013 Genomic Modulators of the Immune Response. Trends in Genetics 29, 74-83 View in PubMed
2012
Fairfax BP, Makino S, Radhakrishnan J, Plant K, Leslie S, Dilthey A, Ellis P, Langford C, Vannberg FO, and Knight JC. 2012 Genetics of gene expression in primary immune cells identifies cell type–specific master regulators and roles of HLA alleles. Nature Genetics 44, 502-510 View in PubMed
Knight, JC. 2012. Resolving the Variable Genome and Epigenome in Human Disease. Journal of Internal Medicine 271, 379-391 View in PubMedSimpson PD, Moysi E, Wicks K, Sudan K, Rowland-Jones SL, McMichael AJ, Knight JC, Gillespie GM. 2012 Functional differences exist between TNFa promoters encoding the common -237G SNP and the rarer HLA-B*5701-Linked A variant. PLoS One 7: e40100. View in PubMed
2011
Vandiedonck C, Taylor MS, Lockstone H, Plant K, Taylor JM, Durrant C, Brockholme J, Fairfax BP, Knight JC. 2011 Pervasive haplotypic variation in the spliceo-transcriptome of the human Major Histocompatibility Complex. Genome Research. doi: 10.1101/gr.116681.110 View in PubMed
Holt R, Dixon AL, Zhang Y, Vandiedonck C, Cookson WO, Knight JC, Moffatt MF. 2011 Allele-specific transcription of the asthma associated gene PHF11 modulated by Oct-1. Journal of Clinical & Experimental Immunology 127, 1054-1062 View in PubMed
Wicks K and Knight JC. 2011 Transcriptional repression and DNA looping associated with a novel regulatory element in the final exon of the lymphotoxin beta gene. Genes and Immunity 12, 126-135 View in PubMed
Andraosa C, Koorsena G, Knight JC, Bornman L. 2011 Vitamin D receptor gene methylation is associated with ethnicity, tuberculosis and TaqI polymorphism. Human Immunology 72, 262-268 View in PubMed
Fairfax P, Davenport E, Makino S, Hill AVS, Vannberg FO, Knight JC. 2011 A common haplotype of the tumour necrosis factor receptor 2 gene modulates endotoxin tolerance. Journal of Immunology 186, 3058-3065 View in PubMed
2010
Paracchini S, Monaco AP, Knight JC. 2010 An allele-specific gene expression assay to test the functional basis of genetic associations. Journal of Visualized Experiments 45 pii: 2279. doi: 10.3791/2279 View in PubMed
Maugeri N, Radhakrishnan J, Knight JC. 2010 Genetic determinants of HSP70 gene expression following heat shock. Human Molecular Genetics 19,4939-4947 View in PubMed
Ramagopalan SV, Heger A, Berlanga AJ, Maugeri NJ, Lincoln MR, Handunnetthi L, Orton S, Handel AE, Watson CT, Morahan JM, Giovannoni G, Ponting CP, Ebers GC, Knight JC. 2010 A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution. Genome Research 20, 1352-1360 View in PubMed
Wong SH, Gochhait S, Malhotra D, Pettersson FH, Teo YY, Khor CC, Rautanen A, Chapman SJ, Mills TC, Srivastava A, Rudko A, Freidin MB, Puzyrev VP, Ali S, Aggarwal S, Chopra R, Reddy BSN, Garg VK, Roy S, Meisner S, Hazra SK, Saha B, Floyd S, Keating BK, Kim C, Fairfax B, Knight JC, Hill PC, Adegbola R, Hakonarson H, Fine PE, Pitchappan R, Bamezai RNK, Hill AVS, Vannberg FO. (2010) Leprosy and the adaptation of human Toll-like receptor 1. PLoS Pathogogens. 6: e1000979 View in PubMed
Knight JC. 2010 Understanding human genetic variation in the era of high throughput sequencing. EMBO Reports 11, 650-652 View in PubMed
Fairfax BP, Vannberg F, Radhakrishnan J, Hakonarson H, Keating BJ, Hill AVS, Knight JC. (2010) An integrated expression phenotype mapping approach defines common variants in LEP, ALOX15 and CAPNS1 associated with induction of IL-6. Human Molecular Genetics 19, 720-730 View in PubMed
Radhakrishnan J, Svoren E, Ellis P, Langford C, Hutton P, Garrard C, Hinds CJ, Knight JC. (2010) Evolution of gene expression signatures in septic shock due to community acquired pneumonia. Journal of the Intensive Care Society 11, 60-61
Handunnetthi L, Ramagopalan SV, Ebers GC, Knight JC. (2010) Regulation of major histocompatibility complex class II gene expression, genetic variation and disease. Genes and Immunity 11, 99-112 View in PubMed
2009
Knight JC (2009) Human Genetic Diversity. Functional Consequences for Health and Disease. Oxford, Oxford University Press. Link
Ramagopalan SV, Maugeri NJ, Lincoln MR, Orton S, Dyment DA, DeLuca GC, Herrera BM, Handunnetthi L, Chao MJ, Sadovnick AD, Ebers GC, Knight JC. (2009) Expression of the Multiple Sclerosis associated MHC class II allele HLA-DRB1*1501 is Regulated by Vitamin D. PLoS Genetics 5 e1000369 View in PubMed
Knight JC. (2009) Insights into the nature and consequences of our variable genome. Briefings in Functional Genomics and Proteomics 8, 343-344 View in PubMed
Knight JC. (2009) Genetic diversity, the Major Histocompatibility Complex and disease: another chapter in a remarkable story. Horizons in Medicine 21, 185-193
Knight JC. (2009) Genetics and the general physician: insights, applications and future challenges. Quarterly Journal of Medicine 102, 757-72 View in PubMed
Gašperíková D, Tribble ND, Staník J, Hučková M, Mišovicová N, van de Bunt M, Valentínová L, Barrow BA, Barák L, Dobránsky R, Bereczková E, Michálek J, Wicks K, Colclough K, Knight JC, Ellard S, Klimeš I, Gloyn AL. (2009). Identification of a novel ß-cell glucokinase (GCK) promoter mutation (-71GC) which modulates GCK gene expression through loss of allele-specific Sp1 binding causing mild fasting hyperglycaemia in humans. Diabetes 58, 1929-35 View in PubMed
Vandiedonck C, Knight JC. (2009). The highly polymorphic Major Histocompatibility Complex as a paradigm in genomics research. Briefings in Functional Genomics and Proteomics doi:10.1093/bfgp/elp010 View in PubMed
Ramagopalan SV, Knight JC, Ebers GC. (2009). Multiple sclerosis and the major histocompatibility complex. Curr Opin Neurol 22, 219-25 View in PubMed
Dennis MY, Paracchini S, Scerri TS, Prokunina-Olsson L, Knight JC, Wade-Martins R, Coggill P, Beck S, Green ED, Monaco AP. (2009). A Common Variant Associated with Dyslexia Reduces Expression of the KIAA0319 Gene. PLoS Genetics 5 e1000436 View in PubMed
2008
Taylor, J. M., K. Wicks, C. Vandiedonck and J. C. Knight (2008). Chromatin profiling across the human tumour necrosis factor gene locus reveals a complex, cell type-specific landscape with novel regulatory elements. Nucleic Acids Res 36(15): 4845-62. View in PubMed
Chao, M. J., M. C. Barnardo, M. R. Lincoln, S. V. Ramagopalan, B. M. Herrera, D. A. Dyment, A. Montpetit, A. D. Sadovnick, J. C. Knight and G. C. Ebers (2008). HLA class I alleles tag HLA-DRB1*1501 haplotypes for differential risk in multiple sclerosis susceptibility. Proc Natl Acad Sci U S A 105(35): 13069-74. View in PubMed
Gordon, A., J. C. Knight and C. J. Hinds (2008). Genes and sepsis: how tight is the fit? Crit Care Med 36(5): 1652-4. 18448923
Garrard, C. S., C. Hinds and J. C. Knight (2008). Applications in Critical Care Medicine. Genomics and Clinical Medicine. D. Kumar and D. Weatherall. Oxford, Oxford University Press.
Other selected publications
Hull, J., S. Campino, K. Rowlands, M. S. Chan, R. R. Copley, M. S. Taylor, K. Rockett, G. Elvidge, B. Keating, J. Knight and D. Kwiatkowski (2007). Identification of common genetic variation that modulates alternative splicing. PLoS Genet 3(6): e99. View in PubMed
Ramagopalan, S. V., M. Knight, G. C. Ebers and J. C. Knight (2007). Origins of magic: review of genetic and epigenetic effects. BMJ 335(7633): 1299-301. View in PubMed
Paracchini, S., A. Thomas, S. Castro, C. Lai, M. Paramasivam, Y. Wang, B. J. Keating, J. M. Taylor, D. F. Hacking, T. Scerri, C. Francks, A. J. Richardson, R. Wade-Martins, J. F. Stein, J. C. Knight, A. J. Copp, J. Loturco and A. P. Monaco (2006). "The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronal migration." Hum Mol Genet 15(10): 1659-66. View in PubMed
Knight, J. C. (2005). "Regulatory polymorphisms underlying complex disease traits." J Mol Med 83(2): 97-109. View in PubMed
Hacking, D., J. C. Knight, K. Rockett, H. Brown, J. Frampton, D. P. Kwiatkowski, J. Hull and I. A. Udalova (2004). "Increased in vivo transcription of an IL-8 haplotype associated with respiratory syncytial virus disease-susceptibility." Genes Immun 5(4): 274-82. View in PubMed
Knight, J. C., B. J. Keating and D. P. Kwiatkowski (2004). "Allele-specific repression of lymphotoxin-alpha by activated B cell factor-1." Nat Genet 36(4): 394-9. View in PubMed
Knight, J. C. (2004). "Allele-specific gene expression uncovered." Trends Genet 20(3): 113-6. View in PubMed
Knight, J. C., B. J. Keating, K. A. Rockett and D. P. Kwiatkowski (2003). "In vivo characterization of regulatory polymorphisms by allele-specific quantification of RNA polymerase loading." Nat Genet 33(4): 469-75. View in PubMed
Knight, J. C., I. Udalova, A. V. Hill, B. M. Greenwood, N. Peshu, K. Marsh and D. Kwiatkowski (1999). "A polymorphism that affects OCT-1 binding to the TNF promoter region is associated with severe malaria." Nat Genet 22(2): 145-50. View in PubMed
McGuire, W., J. C. Knight, A. V. Hill, C. E. Allsopp, B. M. Greenwood and D. Kwiatkowski (1999). "Severe malarial anemia and cerebral malaria are associated with different tumor necrosis factor promoter alleles." J Infect Dis 179(1): 287-90. View in PubMed
Udalova, I. A., J. C. Knight, V. Vidal, S. A. Nedospasov and D. Kwiatkowski (1998). "Complex NF-kappaB interactions at the distal tumor necrosis factor promoter region in human monocytes." J Biol Chem 273(33): 21178-86. View in PubMed
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