Current vacancies 

Postdoctoral Research Scientist in Functional Genomics of Immunity
Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Headington, Oxford
Grade 7: Salary in range £31,604 - £35,550 p.a.

Applications are invited for a Postdoctoral Research Scientist in Functional Genomics of Immunity to join an established team with a track record of innovation and high impact research in the functional genomics of immunity led by Professor Julian Knight at the Wellcome Trust Centre for Human Genetics (WTCHG).

We seek a postdoctoral researcher who is motivated by the opportunity to do outstanding science using recent advances in functional genomics involving induced pluripotent stem cells and genome editing applied to translational research questions. This will be a key component of an exciting new research programme to investigate the functional basis of extreme innate immune response phenotypes contributing to disease, building on our recent work in this area (Science 2014, Lancet Respiratory Medicine 2016). The goal is to advance understanding of the functional alleles driving such differences between individuals, their mechanism of action and their biological consequences in terms of gene regulation, pathophysiology and therapeutic opportunities. You will undertake laboratory work to investigate the functional genomics of the extreme innate immune response and the impact of genetic variation, leveraging the opportunities afforded by induced pluripotent stem cells and high-throughput screens using CRISPR and screening assays together with functional characterisation of specific genes and functional alleles to establish mechanism using appropriate molecular and functional genomic approaches.

You will hold a PhD, or in exceptional cases expected to obtain soon, in genetics, biochemistry, molecular biology or related field and a demonstrable interest in the research described here. You will have demonstrated excellence in molecular biology and functional genomics laboratory techniques. You will have sufficient specialist knowledge to be able to work independently, to identify major challenges and obstacles to the realisation of scientific objectives, and to set out strategies to overcome them. You will also have a strong publication record and motivation to work in a stimulating and ambitious research environment.

We are currently recruiting to three posts for this new programme including this position, a Postdoctoral Research Scientist in Immunogenomics (vacancy ref. 130845) and a Research Assistant in Functional Genomics (vacancy ref. 130844). If you wish to be considered for any of these other posts please submit a separate application for the relevant post.

The position is funded by the Wellcome Trust and is fixed-term until 30 September 2022.

Please quote ref. 130843 on all correspondence. You will be required to upload a CV and supporting statement as part of your online application.

Only applications received before 12.00 midday on Monday 2 October 2017 can be considered.

Please note that the University of Oxford's retirement policy is changing. With effect from October 1 2017, all employees at Grade 8 and above will have a retirement age of 68, and all employees at Grades 6 and 7 will no longer have a set retirement age. Further details are available at: www.ox.ac.uk/about/jobs/preemploymentscreening.

Contact Person : Sarah Hickin Vacancy ID : 130843
Contact Phone : 01865 287507 Closing Date : 02-Oct-2017
Contact Email : personnel@well.ox.ac.uk
Click on the link(s) below to view documentsFilesize 
130843 Postdoctoral Research Scientist-JD 488

 

Postdoctoral Research Scientist in Immunogenomics

Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Headington, Oxford
Grade 7: Salary in range £31,604 - £35,550 p.a.

Applications are invited for a Postdoctoral Research Scientist in Immunogenomics to join an established team with a track record of innovation and high impact research in the functional genomics of immunity led by Professor Julian Knight at the Wellcome Trust Centre for Human Genetics (WTCHG).

We seek a postdoctoral researcher with the ability to use immunological methods in the setting of a genomics programme to address challenging, cutting-edge scientific questions. You will use your skills and experience to play a key role in research to investigate the functional basis of extreme innate immune response phenotypes contributing to disease, building on our recent work in this area (Science 2014, Lancet Respiratory Medicine 2016). The goal is to advance understanding of the functional alleles driving such differences between individuals, their mechanism of action and their biological consequences in terms of gene regulation, pathophysiology and therapeutic opportunities. You will define and functionally characterise specific genes and alleles, and perform the required immune phenotyping and cellular assays. Your work will define the landscape of variable gene regulation in the extreme innate immune response within which disease associated variants act and establish mechanism.

You will hold a PhD, or in exceptional cases expected to obtain soon, in genetics, biochemistry, molecular biology or related field with a demonstrable interest in the research described here. You will have experience of immunology and molecular biology techniques. Experience of functional genomics is desirable. You will have sufficient specialist knowledge to be able to work independently, to identify major challenges and obstacles to the realisation of scientific objectives, and to set out strategies to overcome them. You will also have a strong publication record and motivation to work in a stimulating and ambitious research environment and demonstrable high level of communication skills both written and oral.

We are currently recruiting to three posts for this new programme including this position, a Postdoctoral Research Scientist in Functional Genomics of Immunity (vacancy ref. 130843) and a Research Assistant in Functional Genomics (vacancy ref. 130844). If you wish to be considered for any of these other posts please submit a separate application for the relevant post.

The position is funded by the Wellcome Trust and is fixed-term until 30 September 2022.

Please quote ref. 130845 on all correspondence. You will be required to upload a CV and supporting statement as part of your online application.

Only applications received before 12.00 midday on Monday 2 October 2017 can be considered.

Please note that the University of Oxford's retirement policy is changing. With effect from October 1 2017, all employees at Grade 8 and above will have a retirement age of 68, and all employees at Grades 6 and 7 will no longer have a set retirement age. Further details are available at: www.ox.ac.uk/about/jobs/preemploymentscreening.

Contact Person : Sarah Hickin Vacancy ID : 130845
Contact Phone : 01865 287507 Closing Date : 02-Oct-2017
Contact Email : personnel@well.ox.ac.uk
Click on the link(s) below to view documentsFilesize 
130845 Postdoctoral Research Scientist in Immunogenomics-JD 486.5
     

 Research Assistant in Functional Genomics

Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Headington, Oxford
Grade 6: Salary in range £28,098 - £31,604 p.a.

Applications are invited for a Research Assistant in Functional Genomics to join an established team with a track record of innovation and high impact research in the functional genomics of immunity led by Professor Julian Knight at the Wellcome Trust Centre for Human Genetics (WTCHG).

We seek a highly motivated, organised and proactive individual who will benefit from the exceptional research environment at WTCHG. You will play a key role in an exciting new research programme to investigate the functional basis of extreme innate immune response phenotypes contributing to disease, building on our recent work in this area (Science 2014, Lancet Respiratory Medicine 2016). The goal is to advance understanding of the functional alleles driving such differences between individuals, their mechanism of action and their biological consequences in terms of gene regulation, pathophysiology and therapeutic opportunities. You will be responsible for managing the ongoing sample collection, delivering cell culture and cell purification work together with cloning, sequencing and general molecular biology. You will also play a role in the application of different ‘omic approaches and immunological assays to samples together with opportunities to functionally characterise putative regulatory variants.

You will have a degree in genetics, biochemistry, molecular biology or related field and a demonstrable interest in the research described here. You will also have an experience in standard molecular biology techniques as well as having demonstrable high level of communication skills, both written and oral, and the ability to organise and prioritise work to efficiently deliver results to the required standard and to an agreed schedule. You will be motivated by a stimulating and ambitious research environment with a desire to deliver high quality cutting-edge science and work in a laboratory offering the opportunity for career development and acquiring new expertise.

We are currently recruiting to three posts for this new programme including this position, a Postdoctoral Research Scientist in Functional Genomics of Immunity (vacancy ref. 130843) and Postdoctoral Research Scientist in Immunogenomics (vacancy ref. 130845). If you wish to be considered for any of these other posts please submit a separate application for the relevant post.

The position is funded by the Wellcome Trust and is fixed-term until 30 September 2022.

Please quote ref. 130844 on all correspondence. You will be required to upload a CV and supporting statement as part of your online application.

Only applications received before 12.00 midday on Monday 2 October 2017 can be considered.

Please note that the University of Oxford's retirement policy is changing. With effect from October 1 2017, all employees at Grade 8 and above will have a retirement age of 68, and all employees at Grades 6 and 7 will no longer have a set retirement age. Further details are available at: www.ox.ac.uk/about/jobs/preemploymentscreening.

Contact Person : Sarah Hickin Vacancy ID : 130844
Contact Phone : 01865 287507 Closing Date : 02-Oct-2017
Contact Email : personnel@well.ox.ac.uk
Click on the link(s) below to view documentsFilesize 
130844 Research Assistant in Functional Genomics-JD 487
     

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Studentship

Master of Science (MSc) by Research Studentship in the Functional  genomics of ankylosing spondylitis

Supervisors: Professor Julian Knight and Professor Paul Bowness, University of Oxford; Professor Matt Brown, Queensland University of Technology

Funded by: Arthritis Research UK

Project duration: 2 years

Scientific summary: Applications are invited for a funded research studentship to undertake a Master of Science (MSc) by Research in the Functional Genomics of Ankylosing Spondylitis (AS) at the University of Oxford, with the research to be conducted over two years in Australia and the UK.

We seek a highly motivated, proactive individual who will benefit from an exceptional research opportunity. For the first year, you will be based in Professor Matt Brown’s lab at the Queensland University of Technology in Brisbane Australia (http://staff.qut.edu.au/staff/brownm20/) with the second year at the University of Oxford working under the supervision of Professor Julian Knight (http://www.well.ox.ac.uk/julian-knight-group) and Professor Paul Bowness (https://www.ndorms.ox.ac.uk/team/paul-bowness). You will carry out research to generate a body of work to submit for a Masters by Research. This will require you to undertake laboratory work investigating the functional genomics of ankylosing spondylitis and the impact of genetic variation together with bioinformatic analysis. The research builds on the success of recent genome-wide association studies of this disease (IGAS Consortium 2013 Nature Genetics 45, 730-738), approaches to resolve regulatory variants modulating immune function (Fairfax et al 2014 Science 343: 1246949), and improved understanding of the immunological basis of disease and potential therapy (Hammitzsch 2015 PNAS 112, 10768-73). We aim to fine-map disease associations and establish function for associated genetic variants in a disease context. We propose to characterise the functional alleles driving differences between patients and controls, their mechanism of action and biological consequences in terms of gene regulation, cellular function and disease, helping to enable novel therapeutic insights. You will work as part of a team and be expected to manage your time effectively, prioritising your workload and keep detailed, accurate and comprehensible records of your work. You will be expected to produce work of a high quality, to participate in laboratory meetings and in public engagement activities.

Person specification: Applications are invited from candidates who hold or expect to obtain a First or Upper Second Class Honours Degree in genetics, biochemistry, molecular biology or related field.

Value of the award: The studentship covers the full cost of UK/EU tuition fees for the MSc at the University of Oxford. There is a generous stipend of £14,553 per annum, which is tax-free.

Application process: If you consider that you meet the person specification please email your application to Sibel Ruc, HR Officer at sibel.ruc@well.ox.ac.uk. Your application should consist of an up to date CV and supporting statement, which describes why in your opinion you would be the best candidate for the Masters by Research Studentship. You should also provide full details of two referees and indicate whether they can be contacted at this stage.

Closing date: Applications are to be received by 12:00, noon on Wednesday 11th October 2017.

Other opportunities

Graduate students interested in potentially joining the lab to study for a DPhil are encouraged to contact Julian Knight. A variety of funding opportunities are available including NDM Doctoral Prize Studentships and the Wellcome Trust 4 year PhD programmes in Genomic Medicine and Statistics and Infection, Immunity and Translational Medicine. Funding for clinicians includes the 3 year Wellcome Trust Training Fellowship Programme for Clinicians in Basic Sciences.