Oxford Genomics Centre

The Oxford Genomics Centre, incorporating an MRC High-Throughput Sequencing Hub, is based at the Wellcome Trust Centre for Human Genetics (WTCHG), a research institute of the University of Oxford funded by the Wellcome Trust, MRC and numerous other sponsors.

Genomic technologies, and in particular high-throughput sequencing are revolutionizing modern biomedical genetics, both in pure research and in translating research discoveries into the clinic. Sustaining capability and high-level expertise in these technologies is a key strategic priority of the WTCHG in maintaining its position as one of the leading international research institutes in the field.

The central objective of the Oxford Genomics Centre is to bring together genomics and analysis services to support scientists from Oxford and elsewhere wanting to exploit the latest in high-throughput genomics techniques in their research. We collaborate with the WTCHG’s multidisciplinary research teams in human genetics, functional genomics, epidemiology and structural biology, and with researchers across the world.

The Oxford Genomics Centre is one of the largest genomics facilities in the UK. We specialize in the latest in sequencing and array technology from Illumina, with five Hiseq2000s, two MiSeqs and an iScan system. Our sequencing applications include whole-genome sequencing, targeted sequencing, RNAseq, ChIPseq and methylation analysis. We also undertake focused genotyping using the Sequenom system. With dedicated automation and QC pipelines we support a wide range of experimental protocols.

The Oxford Genomics Centre represents the integration of two strong core groups, High-Throughput Genomics (HTG) led by Dr David Buck and Bioinformatics and Statistical Genetics (BSG) led by Professor Gilean McVean. A real strength of the WTCHG are the scientists who lead the world in the development of bioinformatics tools and analysis methods for high-throughput sequencing and other genomics technologies. We are uniquely placed to apply these tools to the high-quality data we produce.

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