Dr Christine Blancher

Senior Post-doctoral Research Scientist

 

Christine completed a PhD in Molecular and Cellular biology at University Paris VI (Dr P.Crisanti) on isolation and characterization of a novel cDNA expressed during the neuroretina development. She was trained in cancer biology for 4 years as a post-doctoral fellow in the Cancer Research UK unit of Prof. A.L.Harris at the Weatherall Institute of Molecular Medicine in Oxford (UK). Her project focused on the role of the hypoxic response pathway in tumour biology. She returned to Paris for a year as a post-doctoral fellow in the INSERM Unit of Dr P. Crisanti and then went to work in Australia as a Senior Research Officer in the Breast and Ovarian Cancer Genetics unit of Pr I. G. Campbell at the Peter McCallum Cancer Institute in Melbourne. She came back to Oxford to work in the Diabetes Genetics Group of Dr D. Gauguier at the Wellcome Trust Centre for Human Genetics where she gained experience in gene expression and microarray technologies. Her two main areas of interest are the identification of new microRNA targets involved in hypoxia and Chromatin Immunoprecipitation on Affymetrix promoter arrays.

 

Recent Publications

Mole, D. R. Blancher, C. Copley, R. R. Pollard, P. J. Gleadle, J. M. Ragoussis, J. Ratcliffe, P. J. (2009) Genome-wide Association of Hypoxia-inducible Factor (HIF)-1{alpha} and HIF-2{alpha} DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts. J Biol Chem. 284(25): 16767-75. [PMID: 19386601]

Fearnside, J. F. Dumas, M. E. Rothwell, A. R. Wilder, S. P. Cloarec, O. Toye, A. Blancher, C. Holmes, E. Tatoud, R. Barton, R. H. Scott, J. Nicholson, J. K. Gauguier, D. (2008) Phylometabonomic patterns of adaptation to high fat diet feeding in inbred mice. PLoS One 3(2): e1668. [PMID: 18301746]

Toye, A. A. Dumas, M. E. Blancher, C. Rothwell, A. R. Fearnside, J. F. Wilder, S. P. Bihoreau, M. T. Cloarec, O. Azzouzi, I. Young, S. Barton, R. H. Holmes, E. McCarthy, M. I. Tatoud, R. Nicholson, J. K. Scott, J. Gauguier, D. (2007) Subtle metabolic and liver gene transcriptional changes underlie diet-induced fatty liver susceptibility in insulin-resistant mice. Diabetologia 50(9): 1867-79. [PMID: 17618414]

Dumas, M. E. Wilder, S. P. Bihoreau, M. T. Barton, R. H. Fearnside, J. F. Argoud, K. D'Amato, L. Wallis, R. H. Blancher, C. Keun, H. C. Baunsgaard. D. Scott, J. Sidelmann, U. G. Nicholson, J. K. Gauguier, D. (2007) Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models. Nat Genet. 39(5): 666-72. [PMID: 17435758]

Dumas, M. E. Barton, R. H. Toye, A. Cloarec, O. Blancher, C. Rothwell, A. Fearnside, J. Tatoud, R. Blanc, V. Lindon, J. C. Mitchell, S. C. Holmes, E. McCarthy, M. I. Scott, J. Gauguier, D. Nicholson, J. K. (2006) Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice. Proc Natl Acad Sci USA 103(33): 12511-6. [PMID: 16895997]