Nanogenomics: Research Areas
Selective DNA Sequencing
We are developing a single platform for selection and sequencing of DNA fragments of choice direct from genomic DNA. This involves capturing molecules from a complex whole genomic DNA sample onto a microarray and using the array capture probes as primers to initiate DNA synthesis.
Single Molecule Technology
We are approaching the analysis of single DNA molecules from genomic DNA in three ways. The first approach is to make the analysis massively parallel.The second is to make the analysis ultra-fast.The third is to make the analysis long-range or contextual. The work of the group by necessity is multi-disciplinary. In addition to single molecule techniques, this involves molecular biology, fluorescence microscopy, microarray/DNA chip technology, instrumentation, bioinformatics and nanotechnology. To move the work forward we have established a number of collaborations with colleagues within and outside the centre. The group is currently supported by grants from the Wellcome Trust.
Massively parallel analysis of single molecules on surfaces
We have proposed a new platform technology comprising
Based on this platform we are developing novel methods for
Ultra-fast analysis of single molecules moving through nano-confined space
We are also interested detecting local features of linear single DNA polymers as they are
Based on such platforms we are interested in developing ultra-fast methods for