Research areas

People

 
Wellcome Trust Centre for Human Genetics

The Nanogenomics Group

The main objective of the group is to develop experimental tools that will accelerate the finding of genomic factors (e.g. genes, polymorphisms, methylation patterns) that contribute to complex traits. In the long term this may lead to predictive medicine based on personalized genomic information.

Currently available molecular tools are too slow, cumbersome and expensive to allow comprehensive genomic information to be easily obtained from a large number of individuals in a population (e.g. for case/control studies). A radical re-invention of the way genes and DNA are analyzed is needed.

We believe that the analysis of single DNA molecules can overcome many of the present limitations and in addition will reveal information which is inaccessible by conventional methods. To this end, we are also developing methods for sequencing DNA in real time using novel means for observing enzymes during template-directed DNA synthesis.

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