Genome-wide association (GWA) studies have been widely recognised as having huge potential to map genetic polymorphisms contributing to complex human diseases. Consequently, GWA studies of many thousands of SNPs are being undertaken by scientific research groups worldwide, with large samples large enough to detect the modest genetic effects we expect for complex human traits. To maximise the potential of this investment, powerful statistical methods are required for the analysis of GWA data, the development of which forms the basis of my research programme. Specifically, I focus on modelling of multi-locus and haplotype effects, epistasis and gene-environment interaction, multiple phenotypes and rare variants.
My group forms part of the Genetic and Genomic Epidemiology Unit at the Wellcome Trust Centre for Human Genetics, co-led by myself, Dr Cecilia Lindgren and Dr Krina Zondervan. I have close collaborations with Prof. Mark McCarthy and am a member of the analysis groups of the DIAGRAM, ENGAGE, and MAGIC consortia, with a focus on type 2 diabetes and metabolic traits. I am also a member of the NEURODYS consortium (dyslexia), and the fine-mapping and re-sequencing analysis groups of the second phase of the Wellcome Trust Case Control Consortium.
*Andrew Morris has left the Centre for a post at the University of Liverpool, but continues to supervise work in an honorary capacity.