May
2009Dyslexia New Paper! The dyslexia-associated protein KIAA0319 interacts with Adaptor Protein 2 and follows the classical clathrin-mediated endocytosis pathway.
Levecque C, Velayos-Baeza A, Holloway ZG, Monaco AP.
In Am J Physiol Cell Physiol. 2009 May 6. [Epub ahead of print] [PMID: 19419997] [Open Access pdf]April
2009Autism New Paper! High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicates the IMMP2L-DOCK4 gene region in autism susceptibility.
In Molecular Psychiatry, advance online publication, Apr. 28. [Open Access pdf]March
2009Dyslexia A Common Variant Associated with Dyslexia Reduces Expression of the KIAA0319 Gene
In PLOS Genetics March 2009 vol 5(3). [Link to full article (open access pdf)]February
2009Autism Mapping of partially overlapping de novo deletions across an autism susceptibility region (AUTS5) in two unrelated individuals affected by developmental delays with communication impairment.
Accepted by American Journal of Medical GeneticsFebruary
2009Autism Copy number variation and association analysis of SHANK3 as a candidate gene for autism in the IMGSAC collection
Nuala H. Sykes, Claudio Toma, Natalie Wilson, Emanuela V. Volpi, Inês Sousa, Alistair T. Pagnamenta, Raffaella Tancredi, Agatino Battaglia, Elena Maestrini, Anthony J. Bailey, Anthony P. Monaco, IMGSAC
Accepted by European Journal of Human GeneticsFebruary
2009Autism New Paper! High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicates the IMMP2L-DOCK4 gene region in autism susceptibility.
Maestrini E1, Pagnamenta AT, Lamb JA, Bacchelli E, Sykes NH, Sousa I, Toma C, Barnby G, Butler H, Winchester L, Scerri TS, Minopoli F, Reichert J, Cai G, Buxbaum JD, Korvatska O, Schellenberg GD, Dawson G, de Bildt A, Minderaa RB, Mulder EJ, Morris AP, Bailey AJ, Monaco AP, IMGSAC
Accepted by Molecular PsychiatryDecember
2008Autism New Paper! A 15q13.3 microdeletion segregating with autism
Alistair T Pagnamenta, Kirsty Wing, Elham Sadighi Akha, Samantha JL Knight, Sven Bo¨lte, Gabriele Schmo¨tzer, Eftichia Duketis, Fritz Poustka, Sabine M Klauck, Annemarie Poustka, Jiannis Ragoussis, Anthony J Bailey, Anthony P Monaco and IMGSAC
European Journal of Human Genetics (2008), 1 – 6. (advance online publication, 3 December 2008; doi:10.1038/ejhg.200)
[Open Access pdf] [PMID: 19050728]November
2008Autism New Paper! MET and autism susceptibility: family and case-control studies
Sousa I, Clark TG, Toma C, Kobayashi K, Choma M, Holt R, Sykes NH, Lamb JA, Bailey AJ, Battaglia A, Maestrini E, Monaco AP.
European Journal of Human Genetics (2008) Nov 12. [Epub ahead of print]
[Open Access pdf] [PMID: 19002214]
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MONACO GROUP OVERVIEW
1. News
2. People
3. Research teams:
(C) Specific Language Impairment (SLI)
(E) Chorea acanthocytosis (CHAC)
(G) HAndedness and Schizophrenia
4. Publications
5. Funders
7. Further information / Links
8. Contact us
9. Vacancies
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NEUROGENETICS & PSYCHIATRIC DISORDERS: Neurodevelopmental and Neurological Disorders Group Professor Anthony P. Monaco - Group Head
MONACO GROUP OVERVIEW
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| December 2007 | MONACO GROUP NEWSLETTER: Newsletter from the Monaco Group: MONACO GROUP 2007 NEWSLETTER |
| December 2007 | DYSLEXIA NEWSLETTER: Newsletter from the Monaco Dyslexia research team: DYSLEXIA 2007 NEWSLETTER |
Wellcome Trust article: The FOXP2 story
2. People
3. Research
3.1 Neurogenetics research at the Centre
Neurogenetics is one of the main research areas at the Wellcome Trust Centre for Human Genetics (WTCHG).
There are currently six Research Groups working in this area. Link to Centre organigram
3.2 The Monaco Research Group |
The Monaco Research Group aims to identify and characterise genes involved in human neurodevelopmental and neurological disorders.
The study of the genetic basis of these disorders is the first step towards understanding the mechanism of disease and normal brain function as well as providing better strategies for therapy.
The Group works in two main areas:
(1) The genetics of neurodevelopmental disorders: the Group is currently engaged in research on the genetics of the following single-gene (monogenic) neurological diseases: Chorea Acanthocytosis (CHAC) and Menkes disease.
(2) The positional cloning and functional characterization of monogenic neurological diseases: the Group is also engaged in research on the genetics of the following neurodevelopmental disorders: autism, Specific Language Impairment (SLI) and developmental dyslexia. These are all complex genetic disorders. Over the past 15 years or so, there has been remarkable success tracking down genes for single-gene disorders, such as cystic fibrosis, Duchenne muscular dystrophy and Huntington’s disease. But such approaches are not usually powerful enough for complex genetic disorders. Recently, however, novel strategies have been developed that are more appropriate for finding genes influencing complex disorders.
The Group currently comprises the following research teams - please click on the links for further information on the research being carried out by each research team:
Research Teams
Researchers
Neurodevelopmental
disorders
Mr Richard Holt, Dr Alistair Pagnamenta, Ms Inês Sousa, Ms Nuala Sykes, Ms Kirsty Wing
Ms Megan Dennis, Dr Clotilde Lévecque, Dr Silvia Paracchini, Mr Tom Scerri, Dr Antonio Velayos-Baeza
Ms Laura Addis, Dr Dianne Newbury
Mr Julian Asher
Neurological
diseases
Dr Antonio Velayos-Baeza, Dr Clotilde Lévecque
Dr Zoe Holloway
Dr Clyde Franks
In the past, the Neurodevelopmental and Neurological Disorders Group has also carried out research into the following disorders:
Attention-Deficit/ Hyperactivity Disorder (ADHD) / Speech and Language Disorder (SPCH1) / Movement disorders and ataxias / Wilson disease / McLeod Neuroacanthocytosis Syndrome (MLS)
4. Publications
4.1 Most recent publications (2009):
4.2 List of all publications
List of publications for each Research Team:
5. Funders
The Monaco Group is currently receiving grants from the following funders:
6. Research consortia
The Monaco Research Group is a member of the following research consortia and international projects:
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Autism Genome Project (AGP): a large-scale, collaborative international genetics research project that aims to identify autism susceptibility genes.
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Autism MOLGEN Project: an EU-funded autism research project that aims to identify susceptibility alleles for autism and to characterise their biological role.
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Neurodys Project: an EU-funded dyslexia research project that aims to identify candidate genes and the neurobiological basis of dyslexia.
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The International Molecular Genetic Study of Autism Consortium (IMGSAC): a large-scale, collaborative international genetics research project that aims to generate an extensive collection of families with autism and to identify autism susceptibility genes.
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The SLI Consortium (SLIC): a group of scientists in the UK who are working together to unravel the role that genetics plays in the development of Specific Language Impairment (SLI).
7. Further information / Links
7.1 Further information on genetics:
For non-scientists:
Understanding genetic disorders
Techniques for researching genetic disorders
For scientists:
GENE SEARCH: references to specific genes and QTLs on the Monaco Group website
7.2 Links on this site:
7.3 Other links
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Oxford Autism Research Group (Oxford University)
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Oxford Neuroscience website (Oxford University)
8. Contact
For general enquiries to the Monaco Group (Neurodevelopmental and Neurological Disorders Group): monacopa@well.ox.ac.uk
9. Vacancies
The Monaco Group has no vacancies at present.
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Page last updated on Wed Jul 1 10:26:23 2009 |