Mohamed Bellahcene, MSc (Strasbourg), PhD(Basel)

Postdoctoral Fellow

Research summary

Between 2002-2005 I completed a postdoctoral fellowship with Professor Michael Marber at the Rayne Institute, St Thomas’ Hospital, London, investigating signaling pathways initiated by TNFα in the heart.

From 2005-2008 I worked with Professor Michael Cawthorne at the Clore Laboratory, University of Buckingham, on a fellowship from AstraZeneca on the validation of novel targets for diabetes and obesity therapy.

I joined the Department of Cardiovascular Medicine University of Oxford, as part of the Watkins’ group, in 2008. My current primary research interest lies in the role of cardiac energetics and downstream signaling in the development and persistence of cardiomyopathies.

Publication List

Bellahcene, M., J. F. O'Dowd, et al. (2013). "Male mice that lack the G-protein-coupled receptor GPR41 have low energy expenditure and increased body fat content." Br J Nutr 109(10): 1755-1764. View on Pubmed
Oliveira, S. M., Y. H. Zhang, et al. (2012). "AMP-activated protein kinase phosphorylates cardiac troponin I and alters contractility of murine ventricular myocytes." Circ Res 110(9): 1192-1201. View on Pubmed
Ashrafian, H., Czibik, G., Bellahcene, M. & other authors 2012. 'Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway. Cell Metab vol 15, pp 361-371. View on Pubmed
Bellahcene, M., Jacquet, S., Cao, X. B. & other authors 2006. 'Activation of p38 mitogen-activated protein kinase contributes to the early cardiodepressant action of tumor necrosis factor'. J Am Coll Cardiol vol 48, pp 545-555. View on Pubmed

Driamov, S., Bellahcene, M., Ziegler, A., Barbosa, V., Traub, D., Butz, S., Buser, P. T. & Zaugg, C. E. 2004. 'Antiarrhythmic effect of ischemic preconditioning during low-flow ischemia. The role of bradykinin and sarcolemmal versus mitochondrial ATP-sensitive K(+) channels'. Basic Res Cardiol vol 99, pp 299-308. View on Pubmed

Lawrence, K. M., Kabir, A. M., Bellahcene, M. & other authors 2005. 'Cardioprotection mediated by urocortin is dependent on PKCepsilon activation'. FASEB J vol 19, pp 831-833. View on Pubmed

Research Areas

Phenotypic and pre-clinical studies in cardiovascular and metabolic research.

Keywords

Heart, Cardiomyopathies, Metabolism, Diabetes, Obesity.

Contact Details

Email mohamed@well.ox.ac.uk

Sponsor(s)

British Heart Foundation
Wellcome Trust