Mir Group

Research overview

The main objective of the group is to develop experimental tools that will accelerate discovery of genomic variants (sequence, structural and epigenetic) that contribute to complex traits and to provide the technology for individualized genome sequencing that encompasses both short-range sequence and long-range structural variation. In the long term this may lead to predictive medicine based on personalized genomic information. We are part of the EU Framework 7 READNA consortium within which Dr Mir coordinates the Fluorescence-based Single Molecule Sequencing work package.

Publications

Mir KU 2009. Sequencing Genomes: from Individuals to Populations. Briefings in Functional Genomics and Proteomics. (accepted)

Mir KU, Qi H, Salata O and Scozzafava G. 2009. Sequencing by Cyclic Ligation and Cleavage (CycLiC) directly on a microarray captured template, Nucleic Acids Res. Jan;37(1):e5. Epub 2008 Nov 16. PMID: 19015154

Mir KU. 2006. Ultrasensitive RNA profiling: Counting single molecules on microarrays. Genome Research, 16 (10), pp. 1195-7.

Mir KU, Southern EM. 1999. Determining the influence of structure on hybridization using oligonucleotide arrays. Nature Biotechnology, 17 (8), pp. 788-92.

Mir KU, Southern EM. 2000. Sequence variation in genes and genomic DNA: methods for large-scale analysis. Annual review of genomics and human genetics, 1 pp. 329-60.

Funding Sources

European Union Framework 7

The Royal Society

Research Area(s)

Genomics

Keywords

DNA sequencing, nanotechnology, microscopy, microarray, single molecule