Loukas Moutsianas

Loukas picture

Research summary

I am part of the team focused on the genetics of Type 2 Diabetes (GoT2D), where I am looking into the integration of genetic information from multiple sources (e.g. genotyping and resequencing data, imputation) and backgrounds, and issues arising from it. I am paricularly interested in exploring the extend to which traditional statistical methods and novel gene-based ones can interrogate the genome for the effects of rare variants, and how we can increase our confidence in the quality of the analysis results. Our group is led by Professor Mark McCarthy.

More generally, I am interested in understanding the association between genetic variation and susceptibility to complex diseases. To this end, I have been part of the WTCCC2 group, working on the association of the MHC with common complex diseases, with a particular interest on MS. My PhD research was focused in this area. Moreover, I was part of the International HapMap3 Consortium and the 1000 Genomes Project analysis group. More information can be found on my personal webpage.

Publication List

An up-to-date list of publications can be found in my google scholar profile here.

Moutsianas L*, Enciso-Mora V*, Ma YP, Leslie S, Dilthey A, Broderick P, Sherborne A, Cooke R, Ashworth A, Swerdlow AJ, McVean G, Houlston RS. 2011. Multiple Hodgkin lymphoma-associated loci within the HLA region at chromosome 6p21.3. Blood, epub ahead of print. PMID: 21596858

*:joint first authors

Dilthey, A., Moutsianas, L., Leslie, S., and McVean, G. 2011. HLA*IMP, an integrated framework for imputing classical HLA alleles from SNP genotypes. Bioinformatics ,epub ahead of print. PMID: 21300701

Hosking, F. J., Leslie, S., Dilthey, A., Moutsianas, L., Wang, Y., Dobbins, S. E., Papaemmanuil, E., Sheridan, E., Kinsey, S. E., Lightfoot, T., et al. 2010. MHC variation and risk of childhood B-cell precursor acute lymphoblastic leukaemia. Blood. PMID: 21059899

The 1000 Genomes Project Consortium. 2010. A map of human genome variation from population-scale sequencing. Nature 467: 1061-1073. PMID: 20981092

Genetic Analysis of Psoriasis Consortium & the Wellcome Trust Case Control Consortium 2. A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. Nat. Genet.42: 985-990. PMID: 20953190

The International HapMap 3 Consortium. 2010. Integrating common and rare genetic variation in diverse human populations. Nature 467: 52-58. PMID: 20811451

Surakka, I., Kristiansson, K., Anttila, V., Inouye, M., Barnes, C., Moutsianas, L., Salomaa, V., Daly, M., Palotie, A., Peltonen, L., et al. 2010. Founder population-specific HapMap panel increases power in GWA studies through improved imputation accuracy and CNV tagging. Genome Res. PMID: 20810666

Klingelhoefer*, J. W., Moutsianas*, L., and Holmes, C. 2009. Approximate Bayesian feature selection on a large meta-dataset offers novel insights on factors that effect siRNA potency. Bioinformatics 25: 1594-1601. PMID: 19420052
*:joint first authors

van der Wath, E., Moutsianas, L., van der Wath, R., Visagie, A., Milanesi, L., and Lio, P. 2007. Grid methodology for identifying co-regulated genes and transcription factor binding sites. IEEE Trans. Nanobioscience 6: 162-167. PMID: 17695752

Research Area(s)

Association studies, Statistical and Population Genetics, Genetics of Type 2 diabetes, MHC and disease.

Keywords

Data analysis, disease association, statistical power, fine-mapping, resequencing.

Contact Details

Wellcome Trust Centre for Human Genetics
University of Oxford
Roosevelt Drive
Oxford; OX3 7BN; UK
email: moutsian@well.ox.ac.uk

Sponsor(s)