I am part of the team focused on the genetics of Type 2 Diabetes (GoT2D), where I am looking into the integration of genetic information from multiple sources (e.g. genotyping and resequencing data, imputation) and backgrounds, and issues arising from it. For instance, I am interested in exploring how traditional statistical methods for data preparation and analysis cope with rare variants, and how we can increase our confidence in the quality of the data and the analysis results. Our group is led by Professor Mark McCarthy.
More generally, I am interested in understanding the association between genetic variation and susceptibility to complex diseases. To this end, I have been part of the WTCCC2 group, working on the association of the MHC with common complex diseases, with a particular interest on MS. I am now finishing writing up my PhD in this area. Moreover, I was part of the International HapMap3 Consortium and the 1000 Genomes Project analysis group. More information can be found on my personal webpage.
Publication List (plus PubMed IDs)
Moutsianas L*, Enciso-Mora V*, Ma YP, Leslie S, Dilthey A, Broderick P, Sherborne A, Cooke R, Ashworth A, Swerdlow AJ, McVean G, Houlston RS. 2011. Multiple Hodgkin lymphoma-associated loci within the HLA region at chromosome 6p21.3. Blood, epub ahead of print. PMID: 21596858
Dilthey, A., Moutsianas, L., Leslie, S., and McVean, G. 2011. HLA*IMP, an integrated framework for imputing classical HLA alleles from SNP genotypes. Bioinformatics ,epub ahead of print. PMID: 21300701
Hosking, F. J., Leslie, S., Dilthey, A., Moutsianas, L., Wang, Y., Dobbins, S. E., Papaemmanuil, E., Sheridan, E., Kinsey, S. E., Lightfoot, T., et al. 2010. MHC variation and risk of childhood B-cell precursor acute lymphoblastic leukaemia. Blood. PMID: 21059899
The 1000 Genomes Project Consortium. 2010. A map of human genome variation from population-scale sequencing. Nature 467: 1061-1073. PMID: 20981092
Genetic Analysis of Psoriasis Consortium & the Wellcome Trust Case Control Consortium 2. A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. Nat. Genet.42: 985-990. PMID: 20953190
The International HapMap 3 Consortium. 2010. Integrating common and rare genetic variation in diverse human populations. Nature 467: 52-58. PMID: 20811451
Surakka, I., Kristiansson, K., Anttila, V., Inouye, M., Barnes, C., Moutsianas, L., Salomaa, V., Daly, M., Palotie, A., Peltonen, L., et al. 2010. Founder population-specific HapMap panel increases power in GWA studies through improved imputation accuracy and CNV tagging. Genome Res. PMID: 20810666
Klingelhoefer*, J. W., Moutsianas*, L., and Holmes, C. 2009. Approximate Bayesian feature selection on a large meta-dataset offers novel insights on factors that effect siRNA potency. Bioinformatics 25: 1594-1601. PMID: 19420052
*:joint first authors
van der Wath, E., Moutsianas, L., van der Wath, R., Visagie, A., Milanesi, L., and Lio, P. 2007. Grid methodology for identifying co-regulated genes and transcription factor binding sites. IEEE Trans. Nanobioscience 6: 162-167. PMID: 17695752
Association studies, Statistical and Population Genetics, Genetics of Type 2 diabetes, MHC and disease.
Data analysis, disease association, fine-mapping, resequencing, Type 2 diabetes.
Wellcome Trust Centre for Human Genetics
University of Oxford
Oxford; OX3 7BN; UK