Dr Lennard Lee (BMBCh, D.Phil. MA, MRCP)
MRC Clinical Training Research Fellow
Wellcome Trust Centre for Human Genetics, Roosevelt Dr.
My principal research interest is focused on gaining a greater understanding of the molecular factors and development of new treatment strategies for metastasis in colorectal cancer. I am investigating the roles of gene expression changes, immunoregulation, tissue-specificity, aneuploidy and how these factors interact in cell, murine models as well as in human cohorts.
An ultimate aim of my work is to develop a detailed understanding of which types of molecular pathways define and "drive" metastasis at particular sites (for example, liver/lung/bone), allowing the use of stratified therapies to improve outcomes for patients with different patterns of colorectal cancer.