Dr Lennard Lee (BMBCh, D.Phil. MA, MRCP)

Lennard Lee

BRC Clinical Research Career Development Fellow


Wellcome Trust Centre for Human Genetics, Roosevelt Dr. 
Oxford, OX3 7BN


Research summary

My principal research interest is focused on gaining a greater understanding of the molecular factors and development of new treatment strategies for metastasis in colorectal cancer. I am investigating the roles of gene expression changes, immunoregulation, tissue-specificity, aneuploidy and how these factors interact in cell, murine models as well as in human cohorts.
An ultimate aim of my work is to develop a detailed understanding of which types of molecular pathways define and "drive" metastasis at particular sites (for example, liver/lung/bone), allowing the use of stratified therapies to improve outcomes for patients with different patterns of colorectal cancer. 
Following the completion of his postdoctoral post at the WTCHG, Dr Lennard Lee has been recruited to the Institute of Cancer and Genomic Sciences at the University of Birmingham to develop his own research team and interests investigating the molecular and genomic changes that drive late stage cancer progression using human resection specimens, in-vitro and advanced animal models.