Leica TCS SP8 WLL Confocal SMD Microscope

Single molecule detection (SMD) and analysis is an elegant way to examine dynamics and interactions inside cellular systems. Our new Leica TCS SMD Series perfectly integrates the confocal microscope Leica TCS SP8 and the SMD specific software and hardware from PicoQuant into one system.

The Leica TCS WLL SP8 is a freely Tunable Confocal System. The white light laser (WLL) source of the Leica TCS SP8 perfectly matches the spectral properties of any fluorophore excitable in the visible spectral range. Continuously tuneable excitation and detection ensure best image quality and sample protection. Up to eight excitation lines can be used – simultaneously.


Leica SP8 confocal

Confocal system details

Our new new Leica SP8 has been installed in room 00/075. The microscope is suitable for both live cell and fixed specimens on slides, and it will run alongside our old Zeiss LMS 510 MetaHead confocal. The new Leica SP8 has:

At present access to the Leica SP8 SMD confocal system is through members of the Cellular Imaging staff, email us all at cellular-imaging@well.ox.ac.uk. Typically the Zeiss 510 confocal will be used for routine imaging and initial confocal training, with the Leica SP8 reserved for live cell imaging and fixed specimens that may benefit from the Leica SP8's advanced features (feel free to inquire about what the Leica SP8 confocal has to offer).   

Leica SP8 user manuals and brochures

Download the Leica TCS SP8 Quick Start Poster and Core's Abridged Instructions for getting started here. Further help is available via in-program help within the Leica LAS-AF software. There's also the full Leica SP8 User Manual plus the other Leica SP8 confocal manuals: the DMI600 Microscope, the FRAP module and the MotCORR 63x Water Objective.

Additional Leica SP8 confocal flyers and brochures: Hyd Detectors, the SP8 Scan Head, Adaptive Focus Control (AFC), the Leica SP8 SMD, the Leica SP8 X White Light Laser. Application letter: FRET with FLIM.