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From personal genome to personal transcriptome

From personal genome to personal transcriptome

Updated 08/05/2015

Genome analysis reveals how the DNA sequences that make up individual genes differ between individuals, which may contribute to differences in disease risk. However, it remains extremely challenging to accurately predict how any particular DNA ...

Tracing multiple paths through the human genome

Tracing multiple paths through the human genome

Updated 01/05/2015

For the first time, scientists at WTCHG have produced a method of analysing human genomes that takes into account variability between individuals rather than mapping high-throughput sequencing (HTS) data to a single reference genome. They have ...

Major depression leaves a metabolic mark

Major depression leaves a metabolic mark

Updated 23/04/2015

Major depression comes with an unexpected metabolic signature, according to new evidence reported by Na Cai and Jonathan Flint of WTCHG, together with an international team of colleagues. Their findings in humans and mice offer new insight into the ...

Prize for work on colorectal cancer

Prize for work on colorectal cancer

Updated 21/04/2015

Simon Leedham, CRUK Clinician Scientist Fellow at WTCHG and the Translational Gastroenterology Unit, has been named as the recipient of the Sir Francis Avery-Jones BSG Research Award for 2015. The award is made annually by the British Society of ...

Crucial role for repair protein in cancer therapy

Crucial role for repair protein in cancer therapy

Updated 21/04/2015

A study by the Netherlands Cancer Institute, in collaboration with international researchers including Ross Chapman of WTCHG, has discovered why some tumours develop resistance to an important class of anti-cancer drugs. In the normal course of the ...

Major grants to Strubi investigators

Major grants to Strubi investigators

Updated 21/04/2015

Christian Siebold and Juha Huiskonen in the Division of Structural Biology (Strubi) have been awarded prestigious European Research Council (ERC) consolidator grants each of approximately €2 million. These grants support outstanding researchers who ...

Complex genetic ancestry of Americans

Complex genetic ancestry of Americans

Updated 01/04/2015

Oxford researchers including Simon Myers and George Busby of WTCHG have analysed DNA from 4000 people in Europe, Africa and the Americas and found the genetic fingerprints of the slave trade and colonisation that shaped migrations to the Americas hundreds of years ago.

Who do you think you really are?

Who do you think you really are?

Updated 19/03/2015

The first fine-scale analysis of the population of the UK shows that subtle variations in the genetic make-up of modern Britons reflect the history of their islands’ colonisation by peoples from mainland Europe since the last Ice Age. ‘It has long ...

A cut above: structure shows how enzyme suppresses developmental protein

A cut above: structure shows how enzyme suppresses developmental protein

Updated 27/02/2015

A variety of signalling molecules ensure that the process of development from an undifferentiated ball of cells to an adult of the right size and shape proceeds according to plan. Matthias Zebisch at the Structural Biology Division (STRUBI) in ...

New route to polio vaccine

New route to polio vaccine

Updated 17/02/2015

Dave Stuart, co-director of the Structural Biology Division (STRUBI) at WTCHG, is participating in a new programme to develop a synthetic polio vaccine that mimics the structure of the virus while containing no genetic material.