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Investigation of Soluble and Transmembrane CTLA-4 Isoforms in Serum and Microvesicles
Abstract Expression of the CTLA-4 gene is absolutely required for immune homeostasis, but aspects of its molecular nature remain undefined. In particular, the ...
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Rituximab abrogates aquaporin-4-specific germinal center activity in patients with neuromyelitis optica spectrum disorders.
SignificanceBy studying paired blood and deep cervical lymph node samples from patients with neuromyelitis optica spectrum disorders, our data provide evidence ...
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1,1,3-Trioxo-2H,4H-Thieno[3,4-e][1,2,4]Thiadiazine (TTD) Derivatives: a New Class of Nonnucleoside Human Immunodeficiency Virus Type 1 (HIV-1) Reverse Transcriptase Inhibitors with Anti-HIV-1 Activity
<jats:p>We report the development of a new group of nonnucleoside reverse transcriptase inhibitors (NNRTIs). One of the most active congeners of this series of ...
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Intraoperative adenoviral gene transfer of NOS in venous bypass grafts: Reduction of early inflammation and intimal hyperplasia
Nitric oxide (NO), produced by nitric oxide synthase (NOS), plays key roles in the cardiovascular system, including anti-inflammatory actions. Loss of NOS/NO ...
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Structure and lipid-binding properties of the kindlin-3 pleckstrin homology domain
<jats:p>Kindlins co-activate integrins alongside talin. They possess, like talin, a FERM domain (4.1-erythrin–radixin–moiesin domain) comprising F0–F3 ...