Wellcome has announced funding of £118 million to 14 major research centres, including three centres based in Oxford. The Wellcome Centre for Human Genetics, based in Oxford for 22 years, has played a pioneering role in the progress and success of human disease genetics and mechanism research.
We have now made available additional Oxford Nanopore sequencing data, adding raw data files to the existing dataset.
Scientists from the Wellcome Trust Centre for Human Genetics (WTCHG) have used Oxford Nanopore Technologies MinION sequencing devices to sequence two human DNA samples, in an exploration of the capabilities of the pocket-sized, USB-powered sequencing devices.
Dr Rose Wilson, of the Green lab, has written of their experience running a stall at the 'Science Uncovered' late-night event at the Natural History Museum, London.
Dr. Claire Palles, part of the Tomlinson group based at the WTCHG, has been highlighted by the Nuffield Department of Medicine as part of their series of video interviews. Hear more about how Dr. Palles uses whole genome sequencing with the aim of discovering genetic variants that affect susceptibility to colorectal cancer and Barrett’s oesophagus.
Clinicians and researchers are preparing to light Oxford’s Magdalen Tower blue to mark World Diabetes Day – and have invited patients and visitors to then learn more at an open day about the condition at the Churchill Hospital.
Research involving the Tomlinson group has been published in "Cancer Cell" looking at the effect of a gene IDH1R132H in the development of tumours in glial cells, such as the brain. They found that expression of IDH1R132H in the adult mouse brain causes features of glioma development, and a gene expression profile overlapping that of human glial tumours.
An international collaboration, including researchers jointly from the Wellcome Trust Centre of Human Genetics and the Wellcome Trust Sanger Institute, carried out a genome-wide association study on approximately 300 Plasmodium falciparum samples from Cambodia to study the genetic basis behind piperaquine resistance.
New research finds genetic differences that help to explain why some babies are born bigger or smaller than others. The research, led by WTCHG researchers, also reveals how genetic differences provide an important link between an individual’s early growth and their chances of developing conditions such as type 2 diabetes or heart disease in later life.
Sandy Douglas from the Jenner institute features in this Medical Sciences Division podcast on viruses, released to mark World Rabies Day. He discusses the first rabies vaccine and his new strategy to fight rabies using an adenovirus. Other scientists from the Division talk about using viruses to understand how the brain work.