A new study from the JDRF/Wellcome Diabetes and Inflammation Laboratory has identified several novel disease associated candidate genes, which are differentially expressed during T cell activation, using a genome-wide approach to identify contacts between promoters and regulatory sequences containing disease-associated SNPs.
Although naive human T cells underpin the adaptive arm of the immune system, Marcin Pekalski and colleagues have discovered that these cells express innate complement receptors, opening a new avenue in microbial defence in newborn children.
A study co-led by Dr Ben Davies using CRISPR-Cas9 genome editing tools to explore the function of non-coding DNA and its contribution to defining cell identity has been published today in Nature Cell Biology.
Proteins found in tick saliva could be used to treat a potentially fatal form of heart disease, according to new research by the Bhattacharya group
Centre PI Prof Krina Zondervan has been published today in Nature Communications as part of a group investigating new genetic sites associated with endometriosis.
Protection from the most severe form of malaria is linked with natural variation in human red blood cell genes. Led by Professor Dominic Kwiatkowski, researchers from the Wellcome Trust Centre for Human Genetics and the Wellcome Trust Sanger Institute have identified a genetic rearrangement of red blood cell glycophorin receptors that confers a 40% reduced risk from severe malaria.
New research finds genetic differences in antibody genes alter susceptibility to rheumatic heart disease, a forgotten inflammatory heart condition – known as ‘RHD’ – that is rife in developing countries. Rheumatic heart disease is triggered by ...
Congratulations to Prof Yvonne Jones and Prof Hugh Watkins, elected FRS 2017. Professor Jones' research focuses on the structural biology of cell surface recognition and signalling complexes. Professor Watkins is interested in using molecular genetic analysis of cardiovascular disease as a tool to define disease mechanisms and therapeutic targets.
The many potential social and economic benefits from advances in AI-based technologies depend entirely on the environment in which these technologies evolve, says the Royal Society. According to a new report from the UK’s science academy, urgent ...
A big data study of hepatitis C and more than 500 patients with the virus has opened the way for a better understanding of how the virus interacts with its human hosts.