Centre Director Peter Donnelly was interviewed on the Today Programme on Radio 4 on Thursday 19 September 1013, in a package that also featured Regius Professor of Medicine Sir John Bell talking about the promise of 'big data' research projects in finding new approaches to disease.
Over 50 scientists from nine European institutes, including the WTCHG, have measured gene expression by sequencing RNA in human cells from 462 individuals from the the 1000 Genomes Project. Manuel Rivas, Matti Pirinen, Peter Donnelly and Mark McCarthy contributed to the analysis of rare variants of particular medical significance. The study is published in Nature online.
Genetic clue to left- and right-handedness An international collaboration including scientists from the WTCHG has discovered that the same genes that determine asymmetries in the internal body plan of mammals may also play a role in establishing ...
STRUBI's foot and mouth vaccine candidate on TV Professor Dave Stuart, co-director of the Structural Biology Division (STRUBI) at the WTCHG, was interviewed on the popular TV programme Dara O'Briain's Science Club on Thursday 29 August. The ...
Prize for research on diabetes and obesity Cecilia Lindgren, Career Development Fellow at the WTCHG, has been awarded the first Leena Peltonen Prize for Excellence in Human Genetics. Dr Lindgren received the inaugural prize in Helsinki, Finland on ...
The first baby has been born in the US using a new technique developed with researchers at the Wellcome Trust Centre for Human Genetics, in which next-generation sequencing is used to screen IVF embryos for lethal aneuploidies (abnormal chromosome counts). This pioneering test was developed and validated with support from the NIHR Oxford Biomedical Research Centre (BRC) by BRC researchers based at the WTCHG, as part of an international collaboration led by Dr Dagan Wells of the Nuffield Department of Obstetrics and Gynaecology. The new technique is predicted to revolutionise the future of IVF testing.
This animation about research into the malaria parasite and its control has just been launched on YouTube. The animation introduces malaria and goes on to illustrate how DNA sequencing technologies can be used to better track drug resistant malaria ...
A team from the Wellcome Trust Centre for Human Genetics, working with consultant microbiologist Professor Derrick Crook in the John Radcliffe Hospital, has adapted RNA shotgun sequencing to the task of recovering and assembling the whole genomes of viruses in biological samples. They used the method to recover norovirus and hepatitis C from faecal and blood samples, a step towards using whole-genome sequencing for rapid diagnosis in the clinic. The work is part of the 'Modernising Medical Microbiology' initiative funded by the Wellcome Trust and the Medical Research Council, and is published online in Plos One.
Researchers in Structural Biology (STRUBI) at the Wellcome Trust Centre for Human Genetics have demonstrated a new signalling mechanism that operates between cells, and shown how it might be manipulated as a therapy for cancer. Proteins on the ...
Christian Siebold and his colleagues in STRUBI have used the high-intensity X-ray source at Diamond to understand the key interactions of repulsive guidance molecules (RGM) with their receptors. These molecules play a critical role in guiding axons to their targets in the nervous system. His work, published in the journal Science, reveals that RGMs act as ‘molecular staples’, connecting together two receptors that sit adjacent to one another in the cell membrane.
Newt
Pinfox