As part of an international collaboration, the DIL group will identify infants with a significant genetic risk for type 1 diabetes to begin recruiting for POInT, a randomized controlled phase IIb trial to determine if daily administration of high-dose oral insulin in early life can prevent T1D-associated autoimmunity.
Centre leader Prof Simon Leedham has been one of this year's recepients of Cancer Research UK's "Future Leaders" prizes. The CRUK prizes recognise the achievements of the rising stars in cancer research, and celebrate the researchers who have shown outstanding dedication to beating cancer.
Centre Director, Professor Peter Donnelly, features in the latest “Talking Machines” podcast. Peter talks in his capacity with the Royal Society’s Machine Learning Working Group about the work they are doing in relation to Artificial Intelligence and Machine Learning.
A new study from the JDRF/Wellcome Diabetes and Inflammation Laboratory has identified several novel disease associated candidate genes, which are differentially expressed during T cell activation, using a genome-wide approach to identify contacts between promoters and regulatory sequences containing disease-associated SNPs.
Although naive human T cells underpin the adaptive arm of the immune system, Marcin Pekalski and colleagues have discovered that these cells express innate complement receptors, opening a new avenue in microbial defence in newborn children.
A study co-led by Dr Ben Davies using CRISPR-Cas9 genome editing tools to explore the function of non-coding DNA and its contribution to defining cell identity has been published today in Nature Cell Biology.
Proteins found in tick saliva could be used to treat a potentially fatal form of heart disease, according to new research by the Bhattacharya group
Centre PI Prof Krina Zondervan has been published today in Nature Communications as part of a group investigating new genetic sites associated with endometriosis.
Protection from the most severe form of malaria is linked with natural variation in human red blood cell genes. Led by Professor Dominic Kwiatkowski, researchers from the Wellcome Trust Centre for Human Genetics and the Wellcome Trust Sanger Institute have identified a genetic rearrangement of red blood cell glycophorin receptors that confers a 40% reduced risk from severe malaria.
New research finds genetic differences in antibody genes alter susceptibility to rheumatic heart disease, a forgotten inflammatory heart condition – known as ‘RHD’ – that is rife in developing countries. Rheumatic heart disease is triggered by ...