Katie Burnham

DPhil Student

Functional genomics and epigenomics of sepsis

I am working on the functional genomics and epigenomics of sepsis.  Sepsis is the systemic inflammatory response to infection, and is a leading cause of death both in the UK and worldwide.  It is a highly complex disease, and the factors underlying pathogenesis are poorly understood.  As part of the UK Genomic Advances in Sepsis (GAinS) study, I am looking at the inter-individual variation in sepsis susceptibility and outcome.  I will combine disease genetics and functional genomics approaches to investigate disease mechanisms, which should then help to improve treatment of the disease. 

As an undergraduate I read Natural Sciences at the University of Cambridge, where I studied viral resistance in Drosophila.  I then did a Masters in Genetics at the University of Paris Denis Diderot, and worked on a case of meiotic drive at the Centre National de la Recherche Scientifique (C.N.R.S.) Paris-Sud.  I am now working towards a D.Phil in Clinical Medicine as part of the programme run by the Nuffield Department of Medicine, and am funded by the MRC.