Work Summary:

 

Publications:

LOWE, J. K., MALLER, J. B., PE'ER, I., NEALE, B. M., SALIT, J., KENNY, E. E., SHEA, J. L., BURKHARDT, R., SMITH, J. G., JI, W. Z., NOEL, M., FOO, J. N., BLUNDELL, M. L., SKILLING, V., GARCIA, L., SULLIVAN, M. L., LEE, H. E., LABEK, A., FERDOWSIAN, H., AUERBACH, S. B., LIFTON, R. P., NEWTON-CHEH, C., BRESLOW, J. L., STOFFEL, M., DALY, M. J., ALTSHULER, D. M. & FRIEDMAN, J. M. 2009. Genome-Wide Association Studies in an Isolated Founder Population from the Pacific Island of Kosrae. Plos Genetics, 5, 17.

SEDDON, J. M., REYNOLDS, R., MALLER, J., FAGERNESS, J. A., DALY, M. J. & ROSNER, B. 2009. Prediction Model for Prevalence and Incidence of Advanced Age-Related Macular Degeneration Based on Genetic, Demographic, and Environmental Variables. Investigative Ophthalmology & Visual Science, 50, 2044-2053.

FAGERNESS, J., MALLER, J., NEALE, B. & AL., E. 2009. Variation near complement factor I is associated with risk of advanced AMD. EUROPEAN JOURNAL OF HUMAN GENETICS, 17, 100-104.

SMITH, J. G., LOWE, J. K., KOVVALI, S., MALLER, J. B., SALIT, J., DALY, M. J., STOFFEL, M., ALTSHULER, D. M., FRIEDMAN, J. M., BRESLOW, J. L. & NEWTON-CHEH, C. 2009. Genome-wide association study of electrocardiographic conduction measures in an isolated founder population: Kosrae. Heart Rhythm, 6, 634-641.

MCCARROLL, S., KURUVILLA, F., KORN, J. & AL., E. 2008. Integrated detection and population-genetic analysis of SNPs and copy number variation. NATURE GENETICS, 40, 1166-1174.

NEALE, B., LASKY-SU, J., ANNEY, R. & AL., E. 2008. Genome-Wide Association Scan of Attention Deficit Hyperactivity Disorder. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 147B, 1337-1344.

LASKY-SU, J., NEALE, B., FRANKE, B. & AL., E. 2008b. Genome-Wide Association Scan of Quantitative Traits for Attention Deficit Hyperactivity Disorder Identifies Novel Associations and Confirms Candidate Gene Associations. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 147B, 1345-1354.

LASKY-SU, J., ANNEY, R., NEALE, B. & AL., E. 2008a. Genome-Wide Association Scan of the Time to Onset of Attention Deficit Hyperactivity Disorder. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 147B, 1355-1358.

BURKHARDT, R., KENNY, E., LOWE, J. & AL., E. 2008. Common SNPs in HMGCR in Micronesians and Whites Associated With LDL-Cholesterol Levels Affect Alternative Splicing of Exon13. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 28, 2078-U332.

MALLER, J., FAGERNESS, J., REYNOLDS, R. & AL., E. 2007. Variation in complement factor 3 is associated with risk of age-related macular degeneration. NATURE GENETICS, 39, 1200-1201.

PURCELL, S., NEALE, B., TODD-BROWN, K. & AL., E. 2007. PLINK: A tool set for whole-genome association and population-based linkage analyses. AMERICAN JOURNAL OF HUMAN GENETICS, 81, 559-575.

PLENGE, R., COTSAPAS, C., DAVIES, L. & AL., E. 2007. Two independent alleles at 6q23 associated with risk of rheumatoid arthritis. NATURE GENETICS, 39, 1477-1482.

FRAZER, K., BALLINGER, D., COX, D. & AL., E. 2007. A second generation human haplotype map of over 3.1 million SNPs. NATURE, 449, 851-U3.

MALLER, J., GEORGE, S., PURCELL, S. & AL., E. 2006. Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration. NATURE GENETICS, 38, 1055-1059.

PE'ER, I., DE BAKKER, P., MALLER, J. & AL., E. 2006. Evaluating and improving power in whole-genome association studies using fixed marker sets. NATURE GENETICS, 38, 663-667.

International HapMap Consortium. 2005. A haplotype map of the human genome. Nature, 437, 1299-1320.

BARRETT, J., FRY, B., MALLER, J. & AL., E. 2005. Haploview: analysis and visualization of LD and haplotype maps. BIOINFORMATICS, 21, 263-265.

Research Areas:

Genome-wide association methods and population genetics.

Keywords

• GWAS
• Haploview