Dr. John R.B. Perry

Sir Henry Wellcome Postdoctoral Research Fellow

John Perry picture

Research summary

My principle research interest is understanding the genetic architecture of type 2 diabetes. Much of this is based around large-scale genomics projects (GWAS and sequencing), identifying predisposing genetic variation in type 2 diabetes patients. I am also interested in understanding the genetic basis of various reproductive endocrine traits, including menopause, menarche and circulating sex hormones. Many of these intermediate endocrine traits are likely to be causally involved in disease processes, and I am involved in a number of genetic epidemiology studies testing these relationships.

In addition to my post here in Oxford, I hold academic positions at Peninsula Medical School (University of Exeter) and the Department of Twins Research, Kings College London

Research Area(s)

Genetics of Complex Traits / Diseases
Genetic Epidemiology
Type 2 Diabetes and related biomedical traits

Contact Details

Statistical Genetics
Wellcome Trust Centre for Human Genetics
University of Oxford
Roosevelt Drive
Oxford; OX3 7BN; UK

Email: jperry@well.ox.ac.uk

Sponsors

The Wellcome Trust

Diabetes UK

Publications

* denotes equal contribution

[30] Guangju Zhai*, Alexander Teumer*, Lisette Stolk,*, John R.B. Perry*, Liesbeth

Vandenput*, Andrea D. Coviello*, Annemarie Koster*, Stefania Bandinelli, Jordana T

Bell, Shalender Bhasin, Joel Eriksson, Anna Eriksson, Florian Ernst, Luigi Ferrucci,

Timothy M Frayling, Daniel Glass, Elin Grundberg, Robin Haring, Åsa K. Hedman,

Albert Hofman, Douglas P. Kiel, Heyo K. Kroemer, Yongmei Liu, Kathryn L.

Lunetta, Mattias Lorentzon, Massimo Mangino, David Melzer, Iva Miljkovic,

MuTHER consortium, Alexandra Nica, Brenda Penninx, Vasan Ramachandran,

Kerrin S. Small, Nicole Soranzo, André G. Uitterlinden, Henry Völzke, Scott G.

Wilson, Li Xi, Wei Vivian Zhuang, Tamara Harris**, Joanne M. Murabito,**, Claes

Ohlsson**, Anna Murray**, Frank de Jong**, Tim D. Spector**, Henri Wallaschofski**

Eight common genetic variants associated with serum DHEAS levels suggests a key role in ageing mechanisms

PLoS Genetics (In Press)

[29] Jacq Christmas, Ed Keedwell, Timothy M Frayling, John R.B.Perry.

Ant Colony Optimisation to Identify Genetic Variant Association with Type 2 Diabetes

Information Sciences Journal (In Press)

[28] Cathy E. Elks*, John R.B. Perry*, Patrick Sulem*, Daniel I. Chasman, Nora Franceschini, Chunyan He, Kathryn L. Lunetta, Jenny A.Visser, Enda M. Byrne, Diana L. Cousminer, Daniel F. Gudbjartsson, Tõnu Esko, Bjarke Feenstra, Jouke-Jan Hottenga, Daniel L. Koller, Zoltan Kutalik, Peng Lin, Massimo Mangino, Mara Marongiu, Patrick F. McArdle, Albert V. Smith, Lisette Stolk, Sophie W. van Wingerden, Eva Albrecht, Tanguy Corre, Erik Ingelsson, Caroline Haywood, Patrik K.E. Magnusson, Erin N. Smith, Shelia Ulivi, Nicole Warrington, Lina Zgaga, Helen Alavere, Najaf Amin, Thor Aspelund, Stefania Bandinelli, Ines Barroso, Gerald S. Berenson, Hannah Blackburn, Eric Boerwinkle, Julie E. Buring, Fabio Busonero, Harry Campbell, Stephen J. Chanock, Wei Chen, Marilyn C. Cornelis, David Couper, Andrea D. Coviello, Pio d'Adamo, Ulf de Faire, Eco J.C. de Geus, Angela Döring, Douglas F. Easton, Gudny Eiriksdottir, Valur Emilsson, Johan Eriksson, Luigi Ferrucci, Aaron Folsom, Tatiana Foroud, Melissa Garcia, Paolo Gasparini, Frank Geller, Christian Gieger, Vilmundur Gudnason, Per Hall, Susan E. Hankinson, Liana Ferreli, Andrew C. Heath, Dena G. Hernandez, Albert Hofman, FrB. Hu, Siu L Hui, Thomas Illig, Marjo-Ritta Järvelin, Andrew D. Johnson, David Karasik, Kay-Tee Khaw, Douglas P. Kiel, Tuomas Kilpelainen, Ivana Kolcic, Peter Kraft, Lenore J. Launer, Joop S.E. Laven, Shengxu Li, Jianjun Liu, Daniel Levy, Ruth J.F. Loos, Nicholas G. Martin, Mads Melbye, Vincent Mooser, Jeffrey C. Murray, Sarah S. Murray, Michael A. Nalls, Pau Navarro, Mari Nelis, Ben A. Oostra, Munro Peacock, Lyle Palmer, Aarno Palotie, Guillaume Paré, Alex N. Parker, Nancy L. Pedersen, Leena Peltonen, Craig Pennell, Paul Pharoah, Ozren Polasek, Andrew S. Plump, Anneli Pouta, Eleonora Porcu, Thorunn Rafnar, John P. Rice, Fernando Rivadeneira, Igor Rudan,Cinzia Sala, Veikko Salomaa, Serena Sanna, David Schlessinger, Nicholas J. Schork, AngeloScuteri, Alan R. Shuldiner, Nicole Soranzo, Ulla Sovio, Sathanur R. Srinivasan, Kari Stefansson, David P. Strachan, Mar-Liis Tammesoo, Emmi Tikkanen, Laufey Tryggvadottir, Daniela Toniolo, K. Tsui, Jonathon Tyrer, Manuela Uda, Rob M. van Dam, Joyve B.J. van Meurs, Peter Vollenweider, Gerard Waeber, Nicholas J. Wareham, Dawn M. Waterworth, Michael N. Weedon, H. Erich Wichmann, Gonneke Willemsen, James F. Wilson, Alan Wright, Guangju Zhai, Jing Hua Zhao, Wei Vivian Zhuang, Lauren Young, Laura J. Bierut, Dorret I. Boomsma, Heather A. Boyd, Laura Crisponi, Ellen W. Demerath, Michael J. Econs, , Tamara B. Harris, David J. Hunter, Andres Metspalu, Grant W. Montgomery, Paul M. Ridker, Tim D. Spector, Elizabeth A. Streeten, Unnur Thorsteinsdottir, André G. Uitterlinden, Cornelia M. van Duijn, Elisabeth Widen, Joanne M. Murabito, Ken K. Ong, Anna Murray

Thirty two novel loci for age at menarche identified by a meta-analysis of genome-wide association studies

Nature Genetics (2010); Advance online doi:10.1038/ng.714

[27] Anna Murray, Claire E. Bennett, John R.B Perry, Michael N. Weedon, ReproGen Consortium, Patricia A. Jacobs, Danielle Morris, Nick Orr, Minouk Schoemaker, Michael Jones, Alan Ashworth, Anthony Swerdlow.

Common genetic variants are significant risk factors for early menopause

Human Molecular Genetics (2010); Advance online doi: 10.1093/hmg/ddq417

[26] Lango Allen H, Estrada K, Lettre G, Berndt SI, Weedon MN, Rivadeneira F, Willer CJ, Jackson AU, Vedantam S, Raychaudhuri S, Ferreira T, Wood AR, Weyant RJ, Segrè AV, Speliotes EK, Wheeler E, Soranzo N, Park JH, Yang J, Gudbjartsson D, Heard-Costa NL, Randall JC, Qi L, Vernon Smith A, Mägi R, Pastinen T, Liang L, Heid IM, Luan J, Thorleifsson G, Winkler TW, Goddard ME, Sin Lo K, Palmer C, Workalemahu T, Aulchenko YS, Johansson A, Carola Zillikens M, Feitosa MF, Esko T, Johnson T, Ketkar S, Kraft P, Mangino M, Prokopenko I, Absher D, Albrecht E, Ernst F, Glazer NL, Hayward C, Hottenga JJ, Jacobs KB, Knowles JW, Kutalik Z, Monda KL, Polasek O, Preuss M, Rayner NW, Robertson NR, Steinthorsdottir V, Tyrer JP, Voight BF, Wiklund F, Xu J, Hua Zhao J, Nyholt DR, Pellikka N, Perola M, Perry JR, Surakka I, Tammesoo ML, Altmaier EL, Amin N, Aspelund T, Bhangale T, Boucher G, Chasman DI, Chen C, Coin L, Cooper MN, Dixon AL, Gibson Q, Grundberg E, Hao K, Juhani Junttila M, Kaplan LM, Kettunen J, König IR, Kwan T, Lawrence RW, Levinson DF, Lorentzon M, McKnight B, Morris AP, Müller M, Suh Ngwa J, Purcell S, Rafelt S, Salem RM, Salvi E, Sanna S, Shi J, Sovio U, Thompson JR, Turchin MC, Vandenput L, Verlaan DJ, Vitart V, White CC, Ziegler A, Almgren P, Balmforth AJ, Campbell H, Citterio L, De Grandi A, Dominiczak A, Duan J, Elliott P, Elosua R, Eriksson JG, Freimer NB, Geus EJ, Glorioso N, Haiqing S, Hartikainen AL, Havulinna AS, Hicks AA, Hui J, Igl W, Illig T, Jula A, Kajantie E, Kilpeläinen TO, Koiranen M, Kolcic I, Koskinen S, Kovacs P, Laitinen J, Liu J, Lokki ML, Marusic A, Maschio A, Meitinger T, Mulas A, Paré G, Parker AN, Peden JF, Petersmann A, Pichler I, Pietiläinen KH, Pouta A, Ridderstråle M, Rotter JI, Sambrook JG, Sanders AR, Oliver Schmidt C, Sinisalo J, Smit JH, Stringham HM, Bragi Walters G, Widen E, Wild SH, Willemsen G, Zagato L, Zgaga L, Zitting P, Alavere H, Farrall M, McArdle WL, Nelis M, Peters MJ, Ripatti S, van Meurs JB, Aben KK, Ardlie KG, Beckmann JS, Beilby JP, Bergman RN, Bergmann S, Collins FS, Cusi D, den Heijer M, Eiriksdottir G, Gejman PV, Hall AS, Hamsten A, Huikuri HV, Iribarren C, Kähönen M, Kaprio J, Kathiresan S, Kiemeney L, Kocher T, Launer LJ, Lehtimäki T, Melander O, Mosley TH Jr, Musk AW, Nieminen MS, O'Donnell CJ, Ohlsson C, Oostra B, Palmer LJ, Raitakari O, Ridker PM, Rioux JD, Rissanen A, Rivolta C, Schunkert H, Shuldiner AR, Siscovick DS, Stumvoll M, Tönjes A, Tuomilehto J, van Ommen GJ, Viikari J, Heath AC, Martin NG, Montgomery GW, Province MA, Kayser M, Arnold AM, Atwood LD, Boerwinkle E, Chanock SJ, Deloukas P, Gieger C, Grönberg H, Hall P, Hattersley AT, Hengstenberg C, Hoffman W, Mark Lathrop G, Salomaa V, Schreiber S, Uda M, Waterworth D, Wright AF, Assimes TL, Barroso I, Hofman A, Mohlke KL, Boomsma DI, Caulfield MJ, Adrienne Cupples L, Erdmann J, Fox CS, Gudnason V, Gyllensten U, Harris TB, Hayes RB, Jarvelin MR, Mooser V, Munroe PB, Ouwehand WH, Penninx BW, Pramstaller PP, Quertermous T, Rudan I, Samani NJ, Spector TD, Völzke H, Watkins H, Wilson JF, Groop LC, Haritunians T, Hu FB, Kaplan RC, Metspalu A, North KE, Schlessinger D, Wareham NJ, Hunter DJ, O'Connell JR, Strachan DP, Wichmann HE, Borecki IB, van Duijn CM, Schadt EE, Thorsteinsdottir U, Peltonen L, Uitterlinden AG, Visscher PM, Chatterjee N, Loos RJ, Boehnke M, McCarthy MI, Ingelsson E, Lindgren CM, Abecasis GR, Stefansson K, Frayling TM, Hirschhorn JN.

Hundreds of variants influence human height and cluster within genomic loci and biological pathways

Nature (2010); 467(7317):832-8.

[25] Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, Allen HL, Lindgren CM, Luan J, Mägi R, Randall JC, Vedantam S, Winkler TW, Qi L, Workalemahu T, Heid IM, Steinthorsdottir V, Stringham HM, Weedon MN, Wheeler E, Wood AR, Ferreira T, Weyant RJ, Segrè AV, Estrada K, Liang L, Nemesh J, Park JH, Gustafsson S, Kilpeläinen TO, Yang J, Bouatia-Naji N, Esko T, Feitosa MF, Kutalik Z, Mangino M, Raychaudhuri S, Scherag A, Smith AV, Welch R, Zhao JH, Aben KK, Absher DM, Amin N, Dixon AL, Fisher E, Glazer NL, Goddard ME, Heard-Costa NL, Hoesel V, Hottenga JJ, Johansson A, Johnson T, Ketkar S, Lamina C, Li S, Moffatt MF, Myers RH, Narisu N, Perry JR, Peters MJ, Preuss M, Ripatti S, Rivadeneira F, Sandholt C, Scott LJ, Timpson NJ, Tyrer JP, van Wingerden S, Watanabe RM, White CC, Wiklund F, Barlassina C, Chasman DI, Cooper MN, Jansson JO, Lawrence RW, Pellikka N, Prokopenko I, Shi J, Thiering E, Alavere H, Alibrandi MT, Almgren P, Arnold AM, Aspelund T, Atwood LD, Balkau B, Balmforth AJ, Bennett AJ, Ben-Shlomo Y, Bergman RN, Bergmann S, Biebermann H, Blakemore AI, Boes T, Bonnycastle LL, Bornstein SR, Brown MJ, Buchanan TA, Busonero F, Campbell H, Cappuccio FP, Cavalcanti-Proença C, Chen YD, Chen CM, Chines PS, Clarke R, Coin L, Connell J, Day IN, Heijer M, Duan J, Ebrahim S, Elliott P, Elosua R, Eiriksdottir G, Erdos MR, Eriksson JG, Facheris MF, Felix SB, Fischer-Posovszky P, Folsom AR, Friedrich N, Freimer NB, Fu M, Gaget S, Gejman PV, Geus EJ, Gieger C, Gjesing AP, Goel A, Goyette P, Grallert H, Grässler J, Greenawalt DM, Groves CJ, Gudnason V, Guiducci C, Hartikainen AL, Hassanali N, Hall AS, Havulinna AS, Hayward C, Heath AC, Hengstenberg C, Hicks AA, Hinney A, Hofman A, Homuth G, Hui J, Igl W, Iribarren C, Isomaa B, Jacobs KB, Jarick I, Jewell E, John U, Jørgensen T, Jousilahti P, Jula A, Kaakinen M, Kajantie E, Kaplan LM, Kathiresan S, Kettunen J, Kinnunen L, Knowles JW, Kolcic I, König IR, Koskinen S, Kovacs P, Kuusisto J, Kraft P, Kvaløy K, Laitinen J, Lantieri O, Lanzani C, Launer LJ, Lecoeur C, Lehtimäki T, Lettre G, Liu J, Lokki ML, Lorentzon M, Luben RN, Ludwig B; MAGIC, Manunta P, Marek D, Marre M, Martin NG, McArdle WL, McCarthy A, McKnight B, Meitinger T, Melander O, Meyre D, Midthjell K, Montgomery GW, Morken MA, Morris AP, Mulic R, Ngwa JS, Nelis M, Neville MJ, Nyholt DR, O'Donnell CJ, O'Rahilly S, Ong KK, Oostra B, Paré G, Parker AN, Perola M, Pichler I, Pietiläinen KH, Platou CG, Polasek O, Pouta A, Rafelt S, Raitakari O, Rayner NW, Ridderstråle M, Rief W, Ruokonen A, Robertson NR, Rzehak P, Salomaa V, Sanders AR, Sandhu MS, Sanna S, Saramies J, Savolainen MJ, Scherag S, Schipf S, Schreiber S, Schunkert H, Silander K, Sinisalo J, Siscovick DS, Smit JH, Soranzo N, Sovio U, Stephens J, Surakka I, Swift AJ, Tammesoo ML, Tardif JC, Teder-Laving M, Teslovich TM, Thompson JR, Thomson B, Tönjes A, Tuomi T, van Meurs JB, van Ommen GJ, Vatin V, Viikari J, Visvikis-Siest S, Vitart V, Vogel CI, Voight BF, Waite LL, Wallaschofski H, Walters GB, Widen E, Wiegand S, Wild SH, Willemsen G, Witte DR, Witteman JC, Xu J, Zhang Q, Zgaga L, Ziegler A, Zitting P, Beilby JP, Farooqi IS, Hebebrand J, Huikuri HV, James AL, Kähönen M, Levinson DF, Macciardi F, Nieminen MS, Ohlsson C, Palmer LJ, Ridker PM, Stumvoll M, Beckmann JS, Boeing H, Boerwinkle E, Boomsma DI, Caulfield MJ, Chanock SJ, Collins FS, Cupples LA, Smith GD, Erdmann J, Froguel P, Grönberg H, Gyllensten U, Hall P, Hansen T, Harris TB, Hattersley AT, Hayes RB, Heinrich J, Hu FB, Hveem K, Illig T, Jarvelin MR, Kaprio J, Karpe F, Khaw KT, Kiemeney LA, Krude H, Laakso M, Lawlor DA, Metspalu A, Munroe PB, Ouwehand WH, Pedersen O, Penninx BW, Peters A, Pramstaller PP, Quertermous T, Reinehr T, Rissanen A, Rudan I, Samani NJ, Schwarz PE, Shuldiner AR, Spector TD, Tuomilehto J, Uda M, Uitterlinden A, Valle TT, Wabitsch M, Waeber G, Wareham NJ, Watkins H; Procardis Consortium, Wilson JF, Wright AF, Zillikens MC, Chatterjee N, McCarroll SA, Purcell S, Schadt EE, Visscher PM, Assimes TL, Borecki IB, Deloukas P, Fox CS, Groop LC, Haritunians T, Hunter DJ, Kaplan RC, Mohlke KL, O'Connell JR, Peltonen L, Schlessinger D, Strachan DP, van Duijn CM, Wichmann HE, Frayling TM, Thorsteinsdottir U, Abecasis GR, Barroso I, Boehnke M, Stefansson K, North KE, McCarthy MI, Hirschhorn JN, Ingelsson E, Loos RJ

Genome-wide association study of 249,796 individuals reveals eighteen loci associated with body mass index

Nature Genetics (2010); 42(11):937-48

[24] Heid IM*, Jackson AU*, Randall JC*, Winkler TW*, Qi L*, Steinthorsdottir V*, Thorleifsson G*, Zillikens MC, Speliotes EK, Mägi R, Workalemahu T, White CC, Bouatia-Naji N, Harris TB, Berndt SI, Ingelsson E, Willer CJ, Weedon MN, Luan J, Vedantam S, Esko T, Kilpeläinen TO, Kutalik Z, Li S, Monda KL, Dixon AL, Holmes CC, Kaplan LM, Liang L, Min JL, Moffatt MF, Molony C, Nicholson G, Schadt EE, Zondervan KT, Feitosa MF, Ferreira T, Allen HL, Weyant RJ, Wheeler E, Wood AR; MAGIC, Estrada K, Goddard ME, Lettre G, Mangino M, Nyholt DR, Purcell S, Smith AV, Visscher PM, Yang J, McCarroll SA, Nemesh J, Voight BF, Absher D, Amin N, Aspelund T, Coin L, Glazer NL, Hayward C, Heard-Costa NL, Hottenga JJ, Johansson A, Johnson T, Kaakinen M, Kapur K, Ketkar S, Knowles JW, Kraft P, Kraja AT, Lamina C, Leitzmann MF, McKnight B, Morris AP, Ong KK, Perry JR, Peters MJ, Polasek O, Prokopenko I, Rayner NW, Ripatti S, Rivadeneira F, Robertson NR, Sanna S, Sovio U, Surakka I, Teumer A, van Wingerden S, Vitart V, Zhao JH, Cavalcanti-Proença C, Chines PS, Fisher E, Kulzer JR, Lecoeur C, Narisu N, Sandholt C, Scott LJ, Silander K, Stark K, Tammesoo ML, Teslovich TM, Timpson NJ, Watanabe RM, Welch R, Chasman DI, Cooper MN, Jansson JO, Kettunen J, Lawrence RW, Pellikka N, Perola M, Vandenput L, Alavere H, Almgren P, Atwood LD, Bennett AJ, Biffar R, Bonnycastle LL, Bornstein SR, Buchanan TA, Campbell H, Day IN, Dei M, Dörr M, Elliott P, Erdos MR, Eriksson JG, Freimer NB, Fu M, Gaget S, Geus EJ, Gjesing AP, Grallert H, Grässler J, Groves CJ, Guiducci C, Hartikainen AL, Hassanali N, Havulinna AS, Herzig KH, Hicks AA, Hui J, Igl W, Jousilahti P, Jula A, Kajantie E, Kinnunen L, Kolcic I, Koskinen S, Kovacs P, Kroemer HK, Krzelj V, Kuusisto J, Kvaloy K, Laitinen J, Lantieri O, Lathrop GM, Lokki ML, Luben RN, Ludwig B, McArdle WL, McCarthy A, Morken MA, Nelis M, Neville MJ, Paré G, Parker AN, Peden JF, Pichler I, Pietiläinen KH, Platou CG, Pouta A, Ridderstråle M, Samani NJ, Saramies J, Sinisalo J, Smit JH, Strawbridge RJ, Stringham HM, Swift AJ, Teder-Laving M, Thomson B, Usala G, van Meurs JB, van Ommen GJ, Vatin V, Volpato CB, Wallaschofski H, Walters GB, Widen E, Wild SH, Willemsen G, Witte DR, Zgaga L, Zitting P, Beilby JP, James AL, Kähönen M, Lehtimäki T, Nieminen MS, Ohlsson C, Palmer LJ, Raitakari O, Ridker PM, Stumvoll M, Tönjes A, Viikari J, Balkau B, Ben-Shlomo Y, Bergman RN, Boeing H, Smith GD, Ebrahim S, Froguel P, Hansen T, Hengstenberg C, Hveem K, Isomaa B, Jørgensen T, Karpe F, Khaw KT, Laakso M, Lawlor DA, Marre M, Meitinger T, Metspalu A, Midthjell K, Pedersen O, Salomaa V, Schwarz PE, Tuomi T, Tuomilehto J, Valle TT, Wareham NJ, Arnold AM, Beckmann JS, Bergmann S, Boerwinkle E, Boomsma DI, Caulfield MJ, Collins FS, Eiriksdottir G, Gudnason V, Gyllensten U, Hamsten A, Hattersley AT, Hofman A, Hu FB, Illig T, Iribarren C, Jarvelin MR, Kao WH, Kaprio J, Launer LJ, Munroe PB, Oostra B, Penninx BW, Pramstaller PP, Psaty BM, Quertermous T, Rissanen A, Rudan I, Shuldiner AR, Soranzo N, Spector TD, Syvanen AC, Uda M, Uitterlinden A, Völzke H, Vollenweider P, Wilson JF, Witteman JC, Wright AF, Abecasis GR, Boehnke M, Borecki IB, Deloukas P, Frayling TM, Groop LC, Haritunians T, Hunter DJ, Kaplan RC, North KE, O'Connell JR, Peltonen L, Schlessinger D, Strachan DP, Hirschhorn JN, Assimes TL, Wichmann HE, Thorsteinsdottir U, van Duijn CM, Stefansson K, Cupples LA*, Loos RJ*, Barroso I*, McCarthy MI*, Fox CS*, Mohlke KL*, Lindgren CM*.

Meta-analysis identifies 13 novel loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

Nature Genetics (2010) 42(11):949-60

[23] Harries LW, Perry JR, McCullagh P, Crundwell M.

Alterations in LMTK2, MSMB and HNF1B gene expression are associated with the development of prostate cancer.

BMC Cancer (2010); 10:315.

[22] Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, Welch RP, Zeggini E, Huth C, Aulchenko YS, Thorleifsson G, McCulloch LJ, Ferreira T, Grallert H, Amin N, Wu G, Willer CJ, Raychaudhuri S, McCarroll SA, Langenberg C, Hofmann OM, Dupuis J, Qi L, Segrè AV, van Hoek M, Navarro P, Ardlie K, Balkau B, Benediktsson R, Bennett AJ, Blagieva R, Boerwinkle E, Bonnycastle LL, Bengtsson Boström K, Bravenboer B, Bumpstead S, Burtt NP, Charpentier G, Chines PS, Cornelis M, Couper DJ, Crawford G, Doney AS, Elliott KS, Elliott AL, Erdos MR, Fox CS, Franklin CS, Ganser M, Gieger C, Grarup N, Green T, Griffin S, Groves CJ, Guiducci C, Hadjadj S, Hassanali N, Herder C, Isomaa B, Jackson AU, Johnson PR, Jørgensen T, Kao WH, Klopp N, Kong A, Kraft P, Kuusisto J, Lauritzen T, Li M, Lieverse A, Lindgren CM, Lyssenko V, Marre M, Meitinger T, Midthjell K, Morken MA, Narisu N, Nilsson P, Owen KR, Payne F, Perry JR, Petersen AK, Platou C, Proença C, Prokopenko I, Rathmann W, Rayner NW, Robertson NR, Rocheleau G, Roden M, Sampson MJ, Saxena R, Shields BM, Shrader P, Sigurdsson G, Sparsø T, Strassburger K, Stringham HM, Sun Q, Swift AJ, Thorand B, Tichet J, Tuomi T, van Dam RM, van Haeften TW, van Herpt T, van Vliet-Ostaptchouk JV, Walters GB, Weedon MN, Wijmenga C, Witteman J, Bergman RN, Cauchi S, Collins FS, Gloyn AL, Gyllensten U, Hansen T, Hide WA, Hitman GA, Hofman A, Hunter DJ, Hveem K, Laakso M, Mohlke KL, Morris AD, Palmer CN, Pramstaller PP, Rudan I, Sijbrands E, Stein LD, Tuomilehto J, Uitterlinden A, Walker M, Wareham NJ, Watanabe RM, Abecasis GR, Boehm BO, Campbell H, Daly MJ, Hattersley AT, Hu FB, Meigs JB, Pankow JS, Pedersen O, Wichmann HE, Barroso I, Florez JC, Frayling TM, Groop L, Sladek R, Thorsteinsdottir U, Wilson JF, Illig T, Froguel P, van Duijn CM, Stefansson K, Altshuler D, Boehnke M, McCarthy MI; MAGIC investigators; GIANT Consortium

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

Nature Genetics (2010); 42(7):579-89

[21] Furberg H, Kim Y, Dackor J, Boerwinkle E, Franceschini N, Ardissino D, Bernardinelli L, Mannucci PL, Mauri F, Merlini PA, Absher D, Assimes TL, Fortmann SP, Iribarren C, Knowles JW, Quertermous T, Ferrucci L, Tanaka T, Bis JC, Furberg CD, Haritunians T, McKnight B, Psaty BM, Taylor KD, Thacker EL, Almgren P, Groop L, Ladenvall C, Boehnke M, Jackson AU, Mohlke KL, Stringham HM, Tuomilehto J, Benjamin EJ, Hwang SJ, Levy D, Preis SR, Vasan RS, Duan J, Gejman PV, Levinson DF, Sanders AR, Shi J, Lips EH, McKay JD, Agudo A, Barzan L, Bencko V, Benhamou S, Castellsague X, Canova C, Conway DI, Fabianova E, Foretova L, Janout V, Healy CM, Holcátová I, Kjaerheim K, Lagiou P, Lissowska J, Lowry R, Macfarlane TV, Mates D, Richiardi L, Rudnai P, Szeszenia-Dabrowska N, Zaridze D, Znaor A, Lathrop M, Brennan P, Bandinelli S, Frayling TM, Guralnik JM, Milaneschi Y, Perry JR, Altshuler D, Elosua R, Kathiresan S, Lucas G, Melander O, O'Donnell CJ, Salomaa V, Schwartz SM, Voight BF, Penninx BW, Smit JH, Vogelzangs N, Boomsma DI, de Geus EJ, Vink JM, Willemsen G, Chanock SJ, Gu F, Hankinson SE, Hunter DJ, Hofman A, Tiemeier H, Uitterlinden AG, van Duijn CM, Walter S, Chasman DI, Everett BM, Paré G, Ridker PM, Li MD, Maes HH, Audrain-McGovern J, Posthuma D, Thornton LM, Lerman C, Kaprio J, Rose JE, Ioannidis JP, Kraft P, Lin DY, Sullivan PF.

Meta-analyses of genome-wide association studies implicate multiple loci for smoking behaviour

Nature Genetics (2010) 42(5):441-7

[20] Dupuis J*, Langenberg C*, Prokopenko I*, Saxena R*, Soranzo N*, Jackson AU, Wheeler E, Glazer NL, Bouatia-Naji N, Gloyn AL, Lindgren CM, Mägi R, Morris AP, Randall J, Johnson T, Elliott P, Rybin D, Thorleifsson G, Steinthorsdottir V, Henneman P, Grallert H, Dehghan A, Hottenga JJ, Franklin CS, Navarro P, Song K, Goel A, Perry JRB, Egan JM, Lajunen T, Grarup N, Sparsø T, Doney A, Voight BF, Stringham HM, Li M, Kanoni S, Shrader P, Cavalcanti-Proença C, Kumari M, Qi L, Timpson NJ, Gieger C, Zabena C, Rocheleau G, Ingelsson E, An P, O'Connell J, Luan J, Elliott A, McCarroll SA, Payne F, Roccasecca RM, Pattou F, Sethupathy P, Ardlie K, Ariyurek Y, Balkau B, Barter P, Beilby JP, Ben-Shlomo Y, Benediktsson R, Bennett AJ, Bergmann S, Bochud M, Boerwinkle E, Bonnefond A, Bonnycastle LL, Borch-Johnsen K, Böttcher Y, Brunner E, Bumpstead SJ, Charpentier G, Chen Y, Chines P, Clarke R, Coin LJM, Cooper MN, Cornelis M, Crawford G, Crisponi L, Day INM, de Geus E, Delplanque J, Dina C, Erdos MR, Fedson AC, Fischer-Rosinsky A, Forouhi NG, Fox CS, Frants R, Franzosi MG, Galan P, Goodarzi MO, Graessler J, Groves CJ, Grundy S, Gwilliam R, Gyllensten U, Hadjadj S, Hallmans G, Hammond N, Han X, Hartikainen A, Hassanali N, Hayward C, Heath SC, Hercberg S, Herder C, Hicks AA, Hillman DR, Hingorani AD, Hofman A, Hui J, Hung J, Isomaa B, Johnson PRV, Jørgensen T, Jula A, Kaakinen M, Kaprio J, Kesaniemi YA, Kivimaki M, Knight B, Koskinen S, Kovacs P, Kyvik KO, Lathrop GM, Lawlor DA, Bacquer OL, Lecoeur C, Li Y, Lyssenko V, Mahley R, Mangino M, Manning AK, Martínez-Larrad MT, McAteer JB, McCulloch LJ, McPherson R, Meisinger C, Melzer D, Meyre D, Mitchell BD, Morken MA, Mukherjee S, Naitza S, Narisu N, Neville MJ, Oostra BA, Orrù M, Pakyz R, Palmer CNA, Paolisso G, Pattaro C, Pearson D, Peden JF, Pedersen NL, Perola M, Pfeiffer AFH, Pichler I, Polasek O, Posthuma D, Potter SC, Pouta A, Province MA, Psaty BM, Rathmann W, Rayner NW, Rice K, Ripatti S, Rivadeneira F, Roden M, Rolandsson O, Sandbaek A, Sandhu M, Sanna S, Sayer AA, Scheet P, Scott LJ, Seedorf U, Sharp SJ, Shields B, Sigurðsson G, Sijbrands EJG, Silveira A, Simpson L, Singleton A, Smith NL, Sovio U, Swift A, Syddall H, Syvänen A, Tanaka T, Thorand B, Tichet J, Tönjes A, Tuomi T, Uitterlinden AG, van Dijk KW, van Hoek M, Varma D, Visvikis-Siest S, Vitart V, Vogelzangs N, Waeber G, Wagner PJ, Walley A, Walters GB, Ward KL, Watkins H, Weedon MN, Wild SH, Willemsen G, Witteman JCM, Yarnell JWG, Zeggini E, Zelenika D, Zethelius B, Zhai G, Zhao JH, Zillikens MC, DIAGRAM Consortium, GIANT Consortium, Global BPGen Consortium, Borecki IB, Loos RJF, Meneton P, Magnusson PKE, Nathan DM, Williams GH, Hattersley AT, Silander K, Salomaa V, Smith GD, Bornstein SR, Schwarz P, Spranger J, Karpe F, Shuldiner AR, Cooper C, Dedoussis GV, Serrano-Ríos M, Morris AD, Lind L, Palmer LJ, Hu FB, Franks PW, Ebrahim S, Marmot M, Kao WHL, Pankow JS, Sampson MJ, Kuusisto J, Laakso M, Hansen T, Pedersen O, Pramstaller PP, Wichmann HE, Illig T, Rudan I, Wright AF, Stumvoll M, Campbell H, Wilson JF, Hamsten A on behalf of Procardis consortium, Bergman RN, Buchanan TA, Collins FS, Mohlke KL, Tuomilehto J, Valle TT, Altshuler D, Rotter JI, Siscovick DS, Penninx BWJH, Boomsma D, Deloukas P, Spector TD, Frayling TM, Ferrucci L, Kong A, Thorsteinsdottir U, Stefansson K, van Duijn CM, Aulchenko YS, Cao A, Scuteri A, Schlessinger D, Uda M, Ruokonen A, Jarvelin M, Waterworth DM, Vollenweider P, Peltonen L, Mooser V, Abecasis GR, Wareham NJ, Sladek R, Froguel P, Watanabe RM, Meigs JB, Groop L, Boehnke M†, McCarthy MI†, Florez JC† and Barroso I† for the MAGIC investigators.

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.

Nature Genetics (2010); 42(2): 105-16

[19] John R.B. Perry, Michael N Weedon, Claudia Langenberg, Anne U Jackson, Valeriya Lyssenko, Thomas Sparsø, Gudmar Thorleifsson, Harald Grallert, Luigi Ferrucci, Marcello Maggio, Giuseppe Paolisso, Mark Walker, Colin N A Palmer, Felicity Payne, Christian Herder, Narisu Narisu, Mario A Morken, Lori L Bonnycastle, Katharine R Owen, Beverley Shields, Beatrice Knight, Amanda Bennett, Christopher J Groves , Aimo Ruokonen, Marjo Riitta Jarvelin, Ewan Pearson, Laura Pascoe, Ele Ferrannini, Stefan R Bornstein, Heather M Stringham, Laura J Scott, Johanna Kuusisto, Peter Nilsson, Malin Neptin, Anette P. Gjesing, Knut Borch-Johnsen Charlotta Pisinger , Torsten Lauritzen, Annelli Sandbaek, Mike Sampson, MAGIC, Ele Zeggini, Cecilia M Lindgren Valgerdur Steinthorsdottir, Unnur Thorsteinsdottir, Torben Hansen Peter Schwarz, Thomas Illig, Markku Laakso, Kari Stefansson, Andrew Morris, Leif Groop, Oluf Pedersen, Michael Boehnke, Inês Barroso, Nicholas J Wareham, Andrew T Hattersley, Mark I McCarthy, Timothy M Frayling.

Genetic evidence that raised Sex Hormone Binding Globulin (SHBG) levels causally reduce the risk of type 2 diabetes.

Human Molecular Genetics (2010); 19(3): 535-44

[18] Heid IM, Henneman P, Hicks A, Coassin S, Winkler T, Aulchenko YS, Fuchsberger C, Song K, Hivert MF, Waterworth DM, Timpson NJ, Richards JB, Perry JR, Tanaka T, Amin N, Kollerits B, Pichler I, Oostra BA, Thorand B, Frants RR, Illig T, Dupuis J, Glaser B, Spector T, Guralnik J, Egan JM, Florez JC, Evans DM, Soranzo N, Bandinelli S, Carlson OD, Frayling TM, Burling K, Smith GD, Mooser V, Ferrucci L, Meigs JB, Vollenweider P, Dijk KW, Pramstaller P, Kronenberg F, van Duijn CM.

Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: Results of genome-wide association analyses including 4659 European individuals.

Atherosclerosis (2009); 208(2):412-20

[17] J. Brent Richards, Dawn Waterworth, Stephen O'Rahilly, Marie-France Hivert, Ruth J.F. Loos, John R.B. Perry, Toshiko Tanaka, Nicholas John Timpson, Nicole Soranzo, Kijoung Song, Robert K. Semple, Elin Grundberg, Josée Dupuis, Jose C. Florez, Claudia Langenberg, Inga Prokopenko, Richa Saxena, Robert Sladek, Yurii Aulchenko, David Evans, Gerard Waeber, Jeanette Erdmann, Mary-Susan Burnett, Naveed Sattar, Joseph Devaney, Christina Willenborg, Aroon Hingorani, Jaquelin C.M. Witteman, Peter Vollenweider, Christian Hengstenberg, Luigi Ferrucci, David Melzer, John Deanfield, Alistair S. Hall, Josephine M. Egan, John R. Thompson, Sally L. Ricketts, Inke R. König, Scott Grundy, H.-Erich Wichmann, Phil Barter, Robert Mahley, Antero Kesaniemi, Daniel J. Rader, Muredach P. Reilly, Stephen E. Epstein, Alexandre F.R. Stewart, Cornelia M. Van Duijn, Heribert Schunkert, Keith Burling, Panos Deloukas, Tomi Pastinen, Nilesh J. Samani, Ruth McPherson, George Davey Smith, Timothy M. Frayling, Nicholas J. Wareham, James B. Meigs, Vincent Mooser,* Tim D. Spector,*

A genome-wide association study reveals variants in ARL15 that influence adiponectin levels

PLoS Genetics (2009); 5(12):e1000768

[16] John R.B. Perry, Michael N. Weedon, and Timothy M. Frayling

Response to Comment On: Perry et al. (2009) Interrogating Type 2 Diabetes Genome-Wide Association Data Using a Biological Pathway-Based Approach.

Diabetes (2009); 58:1463-1467

[15]John R.B. Perry, Luigi Ferrucci, Stefania Bandinelli, Jack Guralnik, Richard D. Semba, Neil Rice, David Melzer, the DIAGRAM Consortium, Richa Saxena, Laura J Scott, Mark I McCarthy, Andrew T Hattersley, Ele Zeggini, Michael N Weedon, Timothy M Frayling.

Circulating β-carotene levels and Type 2 diabetes: Cause or effect?

Diabetologia (2009); 52: 2117-2121

[14] John R B Perry*, Stolk L*, Franceschini N*, Lunetta KL*, Zhai G*, McArdle PF*, Smith AV, Aspelund T, Bandinelli S, Boerwinkle E, Cherkas L, Eiriksdottir G, Estrada K, Ferrucci L, Folsom AR, Garcia M, Gudnason V, Hofman A, Karasik D, Kiel DP, Launer LJ, van Meurs J, Nalls MA, Rivadeneira F, Shuldiner AR, Singleton A, Soranzo N, Tanaka T, Visser JA, Weedon MN, Wilson SG, Zhuang V, Streeten EA, Harris TB, Murray A, Spector TD, Demerath EW, Uitterlinden AG, Murabito JM.

Meta-analysis of genome-wide association data identifies two loci influencing age at menarche.

Nature Genetics (2009); 41: 648-650

[13] John R.B Perry, Mark I McCarthy, Andrew T Hattersley, Eleftheria Zeggini, The Wellcome Trust Case Control Consortium, Michael N Weedon and Timothy M Frayling

Interrogating type 2 diabetes genome-wide association data using a biological pathway-based approach

Diabetes (2009); 58(6):1463-7.

[12] Rachel M Freathy, Amanda J Bennett, Susan M Ring, Beverley Shields, Christopher J Groves, Nicholas J Timpson, Michael N Weedon, Eleftheria Zeggini, Cecilia M. Lindgren, Hana Lango, John R B Perry, Anneli Pouta, Aimo Ruokonen, Elina Hyppönen, Chris Power, Paul Elliott, David P Strachan, Marjo-Riitta Järvelin, George Davey Smith, Mark I McCarthy,, Timothy M Frayling, and Andrew T Hattersley

Type 2 diabetes risk alleles are associated with reduced size at birth

Diabetes (2009); 58(6):1428-33

[11] Ferrucci L, John R.B. Perry, Matteini A, Perola M, Tanaka T, Silander K, Rice N, Melzer D, Murray A, Cluett C, Fried LP, Albanes D, Corsi AM, Cherubini A, Guralnik J, Bandinelli S, Singleton A, Virtamo J, Walston J, Semba RD, Frayling TM

Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study

American Journal of Human Genetics (2009); 84(2):123-33

[10] Xin Yuan, Dawn Waterworth, John R.B Perry, Noha Lim, Kijoung Song, John C Chambers, Weihua Zhang, Peter Vollenweider, Heide Stirnadel, Toby Johnson, Sven Bergmann, Noam D Beckmann, Luigi Ferrucci, David Melzer, Dena Hernandez, Andrew Singleton, James Scott, Paul Elliott, Gerard Waeber, Lon Cardon, Timothy M Frayling, Jaspal S Kooner and Vincent Mooser.

Population-Based Genome-Wide Association Studies Reveal Four Novel Trans-Acting Loci Influencing Plasma Levels of Liver Enzymes

American Journal of Human Genetics (2008); 83(4):520-8

[9] John R.B. Perry and Timothy Frayling

New gene variants alter type 2 diabetes risk predominantly through reduced beta-cell function [Invited review article]

Current Opinion in clinical nutrition and metabolic care (2008); 11(4):371-7

[8] Michael N Weedon,*, Hana Lango,*, Cecilia M Lindgren, Chris Wallace, David M Evans, Massimo Mangino, Rachel M Freathy, John RB Perry, Suzanne Stevens, Alistair S Hall, Nilesh J Samani, Beverly Shields, Inga Prokopenko, Martin Farrall, Anna Dominiczak, Diabetes Genetics Initiative, The Wellcome Trust Case Control Consortium, Toby Johnson, Sven Bergmann, Jacques S Beckmann, Peter Vollenweider, Dawn M Waterworth, Vincent Mooser, Colin NA Palmer, Andrew D Morris, Willem H Ouwehand, Cambridge GEM Consortium, Mark Caulfield, Patricia B Munroe, Andrew T Hattersley, Mark I McCarthy, Timothy M Frayling

Genome-wide association analysis identifies 20 loci that influence adult height

Nature Genetics (2008); 40(5):575-83

[7] David Melzer*, John R.B.Perry*, Dena Hernandez*, Anna-Maria Corsi, Kara Stevens, Ian Rafferty, Fulvio Lauretani, Anna Murray, J Raphael Gibbs, Giuseppe Paolisso, Sajjad Rafiq, Javier Simon-Sanchez, Hana Lango, Sonja Scholz, Michael N. Weedon, Sampath Arepalli, Neil Rice, Nicole Washecka, Alison Hurst,, Angela Britton, William Henley, Joyce van de Leemput, Rongling Li, Anne B. Newman, Greg Tranah, Tamara Harris, Vijay Panicker, Colin Dayan, Amanda Bennett, Mark I McCarthy , Aimo Ruokonen, Marjo-Riitta Jarvelin, Jack Guralnik, Stefania Bandinelli, Timothy M Frayling*, Andrew Singleton*, Luigi Ferrucci*.

A genome wide association study identifies protein quantitative trait loci (pQTLs)

PLOS Genetics (2008); 4(5):e1000072.

[6] Panicker V, Cluett C, Shields B, Murray A, Parnell K, Perry JRB, Weedon MN, Singleton A, Hernandez D, Evans J, Durant C, Ferrucci L, Melzer, D, Saravanan P, Visser TJ, Ceresini G , Hattersley AT, Vaidya B, Dayan CM and Frayling TM

Common variation in DIO1 alters free T3/T4 ratio

J Clin Endocrinol Metab. 2008 Aug;93(8):3075-81

[5] Eleftheria Zeggini, Laura J Scott, Richa Saxena, & Benjamin F Voight, for the Diabetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

Nature Genetics (2008); 40(5):638-45

[4] Weedon MN*, Lettre G*, Freathy RM*, Lindgren CM*, Voight BF, Perry JRB, Elliott KS, Hackett R, Guiducci C, Shields B, Zeggini E, Lango H, Lyssenko V, Timpson NJ, Burtt NP, Rayner NW, Saxena R, Ardlie K, Tobias JH, Ness AR, Ring SM, Palmer CNA, Morris AD, Peltonen L, Salomaa V, The Diabetes Genetics Initiative, The Wellcome Trust Case Control Consortium, Davey Smith G, Groop LC, Hattersley AT, McCarthy MI, Hirschhorn JN and Frayling TM

A common variant of HMGA2 is associated with adult and childhood height in the general population.

Nature Genetics (2007) ;39:1245-50

[3] Zeggini E*, Weedon MN*, Lindgren CM*, Frayling TM*, Elliott KS, Lango H, Timpson NJ, Perry JR, Rayner NW, Freathy RM, Barrett JC, Shields B, Morris AP, Ellard S, Groves CJ, Harries LW, Marchini JL, Owen KR, Knight B, Cardon LR, Walker M, Hitman GA, Morris AD, Doney AS, Wellcome Trust Case Control Consortium, McCarthy MI^† and Hattersley AT^†:

Replication of Genome-Wide Association Signals in U.K. Samples Reveals Risk Loci for Type 2 Diabetes.

Science (2007) ;316:1336-41

[2] Frayling TM*, Timpson NJ*, Weedon MN*, Zeggini E*, Freathy RM, Lindgren CM, Perry JR, Elliott KS, Lango H, Rayner NW, Shields B, Harries LW, Barrett JC, Ellard S, Groves CJ, Knight B, Patch AM, Ness AR, Ebrahim S, Lawlor DA, Ring SM, Ben-Shlomo Y, Jarvelin MR, Sovio U, Bennett AJ, Melzer D, Ferrucci L, Loos RJ, Barroso I, Wareham NJ, Karpe F, Owen KR, Cardon LR, Walker M, Hitman GA, Palmer CN, Doney AS, Morris AD, Davey-Smith G, Hattersley AT^† and McCarthy MI^†:

A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity.

Science (2007) ;316:889-894

[1] Wellcome Trust Case Control Consortium

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.

Nature. (2007) ;447(7145):661-78