John Peden

Procardis Project Manager

Research Summary

A great deal is already known about the causes of coronary heart disease (CHD), but the differences in disease susceptibility between individuals cannot be explained entirely by known risk factors (such as smoking, hypertension and hyperlipidaemia). Predisposition to CHD involves the complex interaction between a number of genetic and environmental factors, each of which exerts only a modest effect. Age at which CHD presents seems to depend strongly on genetic factors. The PROCARDIS study aims at identifying previously susceptibility genes by studying individuals who have developed CHD at a relatively young age. It is anticipated that this will lead to improved understanding of the pathogenesis of CHD, which, in turn, will aid development of new approaches to diagnosis, prevention and treatment.

Publication List

Peden, J.F., Hopewell, J.C., Saleheen, D. & other authors 2011. 'A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease'. (2011) Nat Genet. Mar 6. [Epub ahead of print] View on Pubmed
Clarke, R., Peden, J. F., Hopewell, J. C. & other authors 2009. 'Genetic variants associated with Lp(a) lipoprotein level and coronary disease', N Engl J Med 361, 2518-2528. View on Pubmed
Broadbent H M, Peden J F, Lorkowski S, Goel A, Ongen H, Green F, Clarke R, Collins R, Franzosi M G, Tognoni G, Seedorf U, Rust S, Eriksson P, Hamsten A, Farrall M, and Watkins H 2007, 'Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked, SNPs in the ANRIL locus on chromosome 9p', Hum Mol Genet. vol 17, no. 6, pp 806-814. View on Pubmed
Farrall Martin, Green Fiona R, Peden John F, Olsson Per G, Clarke Robert, Hellenius Mai-Lis, Rust Stephan, Lagercrantz Jacob, Franzosi Maria G, Schulte Helmut, Carey Alisoun, Olsson Gunnar, Assmann Gerd, Tognoni Gianni, Collins Rory, Hamsten Anders, and Watkins Hugh 2006, 'Genome-wide mapping of susceptibility to coronary artery disease identifies a novel replicated locus on chromosome 17'. PLoS Genet, vol 2, number 5, pp e72. View on Pubmed

Research Areas

Genetics, Bioinformatics

Keywords

Coronary Artery Disease, Bioinformatics, Computational Biology, Procardis

Contact Details

Procardis Project Manager
Wellcome Trust Centre for Human Genetics
Roosevelt Drive,
Oxford,
OX3 7BN, UK