James Groves
DPhil student
Contact details:
Email: jgroves@well.ox.ac.uk
Funders:
The Wellcome Trust
Research interests:
I genetically modify rats for the manipulation of various regions or cell types within the hippocampus. I assess the effect of this manipulation on the behaviour of the rats, with the aim of better understanding the role the hippocampus in controlling emotionality, learning and memory. I use the technique of Recombineering to modify genes within Bacterial Artificial Chromosomes (BACs), which are subsequently incorporated into the rat genome. For example, the ‘GFAP-TK’ rat expresses the Thymidine Kinase (TK) virus from the GFAP promoter, allowing conditional inhibition of the birth of new neurons in the adult rat brain (adult neurogenesis). Comparing the learning and emotional responses of these rats to wildtype controls provides a useful tool for improving our understanding of how these new neurons might contribute to both normal and abnormal human neural processing.
Research areas:
Neurogenesis, neuronal ablation, rat transgenics
Keywords:
Genetics, neurogenesis, rat recombineering, neuronal ablation
Publications list
Click here to search PubMed for all journal articles by JO Groves
- 2009
- Comparing the role of the anterior cingulate cortex and nucleus accumbens dopamine in operant effort-based decision making. Walton ME, Groves J, Jennings KA, Croxson PL, Sharp T, Rushworth MF, Bannerman DM.
Eur J Neurosci. 2009 Apr;29(8):1678-91 [PMID: 19385990]
- Comparing the role of the anterior cingulate cortex and nucleus accumbens dopamine in operant effort-based decision making. Walton ME, Groves J, Jennings KA, Croxson PL, Sharp T, Rushworth MF, Bannerman DM.
- 2007
- Is it time to reassess the BDNF hypothesis of depression? Groves JO. Mol Psychiatry. 2007 Dec;12(12):1079-88. Epub 2007 Aug 14 [PMID: 17700574] [Full text]
- 2006
- The role of GABAbeta2 subunit-containing receptors in mediating the anticonvulsant and sedative effects of loreclezole. Groves JO, Guscott MR, Hallett DJ, Rosahl TW, Pike A, Davies A, Wafford KA, Reynolds DS. Eur J Neurosci. 2006 Jul;24(1):167-74. [PubMed 16882014]
- Sensitivity of late-latency auditory and somatosensory evoked potentials to threat of electric shock and the sedative drugs diazepam and diphenhydramine in human volunteers. Scaife JC, Groves J, Langley RW, Bradshaw CM, Szabadi E. J Psychopharmacol. 2006 Jul;20(4):485-95. Epub 2005 Oct 4. [PubMed: 16204321]
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