Enhancing protective immunity to malaria with a highly immunogenic virus-like particle vaccine. Sci Rep, 7, pp. 46621. Article
Up-regulation of miR-31 in human atrial fibrillation begets the arrhythmia by depleting dystrophin and neuronal nitric oxide synthase. Sci Transl Med, 8 (340), pp. 340ra74. Article
Urgent improvements needed to diagnose and manage Lynch syndrome. BMJ, 356, pp. j1388. Article
Bone morphogenetic protein and Notch signalling crosstalk in poor-prognosis, mesenchymal-subtype colorectal cancer. J Pathol. Article
Human IL-6R(hi)TIGIT(-) CD4(+)CD127(low)CD25(+) T cells display potent in vitro suppressive capacity and a distinct Th17 profile. Clin Immunol, 179, pp. 25-39. Article
Same-Day Diagnostic and Surveillance Data for Tuberculosis via Whole-Genome Sequencing of Direct Respiratory Samples. J Clin Microbiol, 55 (5), pp. 1285-1298. ArticleMore publications
Centre PI Prof Krina Zondervan has been published today in Nature Communications as part of a group investigating new genetic sites associated with endometriosis.
Protection from the most severe form of malaria is linked with natural variation in human red blood cell genes. Led by Professor Dominic Kwiatkowski, researchers from the Wellcome Trust Centre for Human Genetics and the Wellcome Trust Sanger Institute have identified a genetic rearrangement of red blood cell glycophorin receptors that confers a 40% reduced risk from severe malaria.
New research finds genetic differences in antibody genes alter susceptibility to rheumatic heart disease, a forgotten inflammatory heart condition – known as ‘RHD’ – that is rife in developing countries. Rheumatic heart disease is triggered by ...