|
Interferon-alpha receptor-1 (IFNAR1) variants are associated with protection against
cerebral malaria in The |
||||||||
|
Christophe Aucan,
Andrew J. Walley, Angela Frodsham, Lyna Zhang,
Genes Immun. 2003 Jun;4(4):275-82.
Additional informations: |
||||||||
|
Polymorphic markers from chromosome 21q22.1
in The Gambia |
||||||||
|
Candidate Genes |
Markers |
Gene Location |
Variants1 |
Controls |
Severe Malaria |
Cerebral Malaria |
Severe Anaemia |
Mild Malaria |
|
IFNAR2 |
F10V |
Exon 2 |
T/G n= |
(0.87) 2 561 |
(0.85) 500 |
(0.84) 312 |
(0.86) 117 |
(0.91) 232 |
|
|
A285T |
Exon 9 |
G/A n= |
(0.69) 507 |
(0.67) 496 |
(0.66) 310 |
(0.67) 116 |
(0.70) 226 |
|
|
|
|
|
|
|
|
|
|
|
Candidate Genes |
Markers |
Gene Location |
Variants1 |
Controls |
Severe Malaria |
Cerebral Malaria |
Severe Anaemia |
Mild Malaria |
|
IL10RB |
K47E |
Exon 2 |
A/G n= |
(0.94) 2 414 |
(0.94) 373 |
(0.94) 237 |
(0.92) 92 |
(0.94) 231 |
|
|
CA-1-repeat |
Intron 6 |
CA n= |
(0.76) 3 188 |
(0.77) 187 |
ND |
ND |
|
|
|
CA-2-repeat |
Intron 6 |
CA n= |
(0.55) 188 |
(0.50) 187 |
ND |
ND |
ND |
|
|
|
|
|
|
|
|
|
|
|
Candidate Genes |
Markers |
Gene Location |
Variants1 |
Controls |
Severe Malaria |
Cerebral Malaria |
Severe Anaemia |
Mild Malaria |
|
IFNAR1 |
-408 |
Promoter |
C/T n= |
(0.95) 2 547 |
(0.96) 528 |
(0.96) 320 |
(0.96) 135 |
(0.95) 338 |
|
|
GT-repeat |
Promoter |
GT n= |
(0.73) 3 488 |
(0.77) 464 |
(0.80) 294 |
(0.75) 106 |
(0.72) 212 |
|
|
17470 |
Intron 3 |
G/C n= |
(0.66) 554 |
(0.64) 528 |
(0.62) 319 |
(0.65) 136 |
(0.65) 338 |
|
|
L168V |
Exon 4 |
G/C n= |
(0.73) 532 |
(0.73) 467 |
(0.72) 327 |
(0.74) 137 |
(0.72) 335 |
|
|
IVS-repeat |
Intron 5 |
ATTT n= |
(0.76) 510 |
(0.76) 479 |
(0.78) 303 |
(0.75) 108 |
(0.76) 218 |
|
|
30175 |
Intron 10 |
T/G n= |
(0.80) 557 |
(0.82) 530 |
(0.83) 320 |
(0.82) 137 |
(0.81) 340 |
|
|
|
|
|
|
|
|
|
|
|
Candidate Genes |
Markers |
Gene Location |
Variants1 |
Controls |
Severe Malaria |
Cerebral Malaria |
Severe Anaemia |
Mild Malaria |
|
IFNGR2 |
D21S370-repeat |
5’UTR |
GT n= |
(0.73) 3 186 |
(0.71) 183 |
ND |
ND |
|
|
|
30354 |
Intron 2 |
C/T n= |
(0.71) 2 185 |
(0.70) 183 |
ND |
ND |
ND |
|
|
46334 |
3’UTR |
G/A n= |
(0.97) 309 |
(0.97) 201 |
ND |
ND |
ND |
|
|
46341 |
3’UTR |
T/C n= |
(0.83) 307 |
(0.84) 198 |
ND |
ND |
ND |
|
|
||||||||
|
Legend: This table shows the 15 genetic markers studied within four candidate genes from the 21q22.1 locus. 1 common alleles / rare allele, or nucleotide repeat for microsatellites markers. 2 For SNP markers, allele frequencies within controls or malaria groups are given in parentheses for the most common allele. 3 For microsatellites markers, frequencies of heterozygous samples are given in parentheses. Numbers of studied samples are given for controls and malaria cases. UTR; untranslated region. ND; Not determined. |
||||||||