Work summary

I am currently studying the population genetics of the platypus, using whole-genome sequence (WGS) data to learn about demographic history, recombination and selection. I am also working on aspects of the WGS500 project, a large medical sequencing project at the Centre, focusing on some Mendelian neurological diseases, particularly early infantile epilepsies. 

Before coming to Oxford, I worked at various times on miRNA targeting, the evolution of gene regulation in yeast, and the effects of the environment on human gene expression.

Selected publications

Here are my publications from previous projects:

Idaghdour Y, Czika W, Shianna KV, Lee SH, Visscher PM, Martin HC, Miclaus K, Jadallah SJ, Goldstein DB, Wolfinger RD, Gibson G. Geographical genomics of human leukocyte gene expression variation in southern Morocco. Nat Genet. 2010;42(1):62-7. doi: 10.1038/ng.495. Epub 2009 Dec 6.

Martin HC, Roop JI, Schraiber JG, Hsu TY, Brem RB. Evolution of a membrane protein reglon in Saccharomyces. Mol Biol Evol. 2012;29(7):1747-56. doi: 10.1093/molbev/mss017. Epub 2012 Jan 20.

Cloonan N, Wani S, Xu Q, et al. MicroRNAs and their isomiRs function cooperatively to target common biological pathways. Genome Biol. 2011;12(12):R126. doi: 10.1186/gb-2011-12-12-r126.

Krishnan K, Steptoe AL, Martin HC, et al. RNA. MicroRNA-182-5p targets a network of genes involved in DNA repair. 2013;19(2):230-42. doi: 10.1261/rna.034926.112. Epub 2012 Dec 18.