Geraldine M. Clarke

Geraldine

 

I am a statistical geneticist working in human population genetics. In summary, my research combines both theoretical work and empirical analysis with a view to characterising and identifying genetic influences on complex human traits and diseases. There are three main threads to my research (i) identification and description of genetic influences on complex human traits and diseases; (ii) development of efficient statistical methods and novel algorithms for the location of genes that lead to common diseases and; (iii) the application of these and other approaches to real data. I am also a guest lecturer teaching Medical Statistics in the Statistics department at the University of Warwick.   

Publications

2010

Clarke GM, Cardon LR. Aspects of observing and claiming allele flips in association studies. Genet Epidemiol. Apr;34:266-74. 2010. PMID: 20013941

Anderson CA, Pettersson FH, Clarke GM, Cardon LR, Morris AP, Zondervan KT. Data quality control in genetic case-control association studies. Nat Protoc. Aug;5:1564-73. 2010.  PMID: 21085122

Clarke GM, Morris AP. A comparison of sample size and power in case-only association studies of gene-environment interaction. Am J Epidemiol. Feb 15;171:498-505. 2010.  PMID: 20047976 

Cho EY, Jang Y, Shin ES, Jang HY, Yoo Y-K, Kim S, Jang JH, Lee JY, Yun MH, et al. Genome-wide association analysis and replication of coronary artery disease in South Korea suggests a causal variant common to diverse populations. Heart Asia. January 1;2:104-8. 2010.  

Cummings JR, Cooney RM, Clarke G, Beckly J, Geremia A, Pathan S, Hancock L, Guo C, Cardon LR, Jewell DP. The genetics of NOD-like receptors in Crohn's disease. Tissue Antigens. Jul;76:48-56. 2010.  PMID: 20403135

Clarke GM, Anderson CA, Pettersson FH, Cardon LR, Morris AP, Zondervan KT. Basic statistical analysis in genetic case-control studies. Nat Protoc. Oct;In press. 2010. 

2009

Clarke GM, Pettersson FH, Morris AP. A comparison of case-only designs for detecting gene x gene interaction in rheumatoid arthritis using genome-wide case-control data in Genetic Analysis Workshop 16. BMC Proc. 3 Suppl. Dec 15;7:S73. 2009. PMID: 20018068

Pettersson FH, Anderson CA, Clarke GM, Barrett JC, Cardon LR, Morris AP, Zondervan KT. Marker selection for genetic case-control association studies. Nat Protoc. Apr;4:743-52. 2009.  PMID: 19390530 

An P, Mukherjee O, Chanda P, Yao L, Engelman CD, Huang CH, Zheng T, Kovac IP, Dube MP, et al. The challenge of detecting epistasis (G x G interactions): Genetic Analysis Workshop 16. Genet Epidemiol. 33 Suppl 1:S58-67. 2009.  PMID: 19924703

Cho YS, Go MJ, Kim YJ, Heo JY, Oh JH, Ban HJ, Yoon D, Lee MH, Kim DJ, et al. A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. Nat Genet. May;41:527-34. 2009. PMID: 19396169

2008

Cummings J, Cooney R, Clarke GM, Beckly J, Geremia A, Cardon LR, Jewell D. The genetics of nod-like receptors proteins in Crohn's disease. J Crohn's Colitis Supp. 2008:61.  

2007

Tenesa A, Navarro P, Hayes BJ, Duffy DL, Clarke GM, Goddard ME, Visscher PM. Recent human effective population size estimated from linkage disequilibrium. Genome Res. 17:520-526. 2007. PMID: 17351134

Sabeti PC, Varilly P, Fry B, Lohmueller J, Hostetter E, Cotsapas C, Xie X, Byrne EH, McCarroll SA, Gaudet R, Schaffner SF, Lander ES; International HapMap Consortium, Frazer KA, Ballinger DG, Cox DR, Hinds DA, Stuve LL, Gibbs RA, Belmont JW, Boudreau A, Hardenbol P, Leal SM, Pasternak S,Wheeler DA, Willis TD, Yu F, Yang H, Zeng C, Gao Y, Hu H, Hu W, Li C, Lin W, Liu S, Pan H, Tang X, Wang J, Wang W, Yu J, Zhang B, Zhang Q, Zhao H,Zhao H, Zhou J, Gabriel SB, Barry R, Blumenstiel B, Camargo A, Defelice M, Faggart M, Goyette M, Gupta S, Moore J, Nguyen H, Onofrio RC, Parkin M,Roy J, Stahl E, Winchester E, Ziaugra L, Altshuler D, Shen Y, Yao Z, Huang W, Chu X, He Y, Jin L, Liu Y, Shen Y, Sun W, Wang H, Wang Y, Wang Y, Xiong X, Xu L, Waye MM, Tsui SK, Xue H, Wong JT, Galver LM, Fan JB, Gunderson K, Murray SS, Oliphant AR, Chee MS, Montpetit A, Chagnon F, Ferretti V, Leboeuf M, Olivier JF, Phillips MS, Roumy S, Sallée C, Verner A, Hudson TJ, Kwok PY, Cai D, Koboldt DC, Miller RD, Pawlikowska L, Taillon-Miller P,Xiao M, Tsui LC, Mak W, Song YQ, Tam PK, Nakamura Y, Kawaguchi T, Kitamoto T, Morizono T, Nagashima A, Ohnishi Y, Sekine A, Tanaka T, Tsunoda T, Deloukas P, Bird CP, Delgado M, Dermitzakis ET, Gwilliam R, Hunt S, Morrison J, Powell D, Stranger BE, Whittaker P, Bentley DR, Daly MJ, de Bakker PI, Barrett J, Chretien YR, Maller J, McCarroll S, Patterson N, Pe'er I, Price A, Purcell S, Richter DJ, Sabeti P, Saxena R, Schaffner SF, Sham PC, Varilly P,Altshuler D, Stein LD, Krishnan L, Smith AV, Tello-Ruiz MK, Thorisson GA, Chakravarti A, Chen PE, Cutler DJ, Kashuk CS, Lin S, Abecasis GR, Guan W,Li Y, Munro HM, Qin ZS, Thomas DJ, McVean G, Auton A, Bottolo L, Cardin N, Eyheramendy S, Freeman C, Marchini J, Myers S, Spencer C, Stephens M,Donnelly P, Cardon LR, Clarke G, Evans DM, Morris AP, Weir BS, Tsunoda T, Johnson TA, Mullikin JC, Sherry ST, Feolo M, Skol A, Zhang H, Zeng C,Zhao H, Matsuda I, Fukushima Y, Macer DR, Suda E, Rotimi CN, Adebamowo CA, Ajayi I, Aniagwu T, Marshall PA, Nkwodimmah C, Royal CD, Leppert MF, Dixon M, Peiffer A, Qiu R, Kent A, Kato K, Niikawa N, Adewole IF, Knoppers BM, Foster MW, Clayton EW, Watkin J, Gibbs RA, Belmont JW, Muzny D,Nazareth L, Sodergren E, Weinstock GM, Wheeler DA, Yakub I, Gabriel SB, Onofrio RC, Richter DJ, Ziaugra L, Birren BW, Daly MJ, Altshuler D, Wilson RK, Fulton LL, Rogers J, Burton J, Carter NP, Clee CM, Griffiths M, Jones MC, McLay K, Plumb RW, Ross MT, Sims SK, Willey DL, Chen Z, Han H, Kang L, Godbout M, Wallenburg JC, L'Archevêque P, Bellemare G, Saeki K, Wang H, An D, Fu H, Li Q, Wang Z, Wang R, Holden AL, Brooks LD, McEwen JE,Guyer MS, Wang VO, Peterson JL, Shi M, Spiegel J, Sung LM, Zacharia LF, Collins FS, Kennedy K, Jamieson R, Stewart J.  Genome-wide detection and characterization of positive selection in human populations. Nature. 449:913-918. 2007.  PMID: 17943131

Frazer KA, Ballinger DG, Cox DR, Hinds DA, Stuve LL, Gibbs RA, Belmont JW, Boudreau A, Hardenbol P, Leal SM, et al: A second generation human haplotype map of over 3.1 million SNPs. Nature.449:851-861. 2007.  

Clarke GM, Carter KW, Palmer LJ, Morris AP, Cardon LR: Fine mapping versus replication in whole-genome association studies. Am J Hum Genet. 81:995-1005. 2007.  

Clarke G, Whittemore AS: Comparison of admixture and association mapping in admixed families. Genet Epidemiol. 31:763-775. 2007.  PMID: 17508341

2005

Clarke GM, Cardon LR: Disentangling linkage disequilibrium and linkage from dense single-nucleotide polymorphism trio data. Genetics.171:2085-2095. 2005.  

Consortium IH: A haplotype map of the human genome. Nature. 437:1299-1320. 2005.  PMID: 16255080

2000

Clarke G, Whittemore AS: Prostate cancer risk in relation to anthropometry and physical activity: the National Health and Nutrition Examination Survey I Epidemiological Follow-Up Study. Cancer Epidemiol Biomarkers Prev. 9:875-881. 2000. PMID: 11008903