Kate Wicks

Kate Wicks

Updated 15/06/2009

The genes of the tumor necrosis factor (TNF) superfamily in the class III region of the MHC are tightly regulated at the transcriptional level. Whilst the regulation of TNF is relatively well characterised, much less is known about the regulation of ...

Dr Peter Humburg

Updated 08/01/2012

We are using functional genomic approaches to define genetic variants that are responsible for the association of genetic variation in the Major Histocompatibility Complex (MHC) with susceptibility to autoimmune, infectious and inflammatory disease. ...

Dr Katharine Plant

Dr Katharine Plant

Updated 15/06/2009

I am working on the GenExpressID project, which aims to characterise gene expression in patients of various autoimmune diseases within different immune cell types.  We are hoping to determine unique expression signatures that are associated with ...

Seiko Makino

Seiko Makino

Updated 14/07/2010

Inflammation is dependent on a number of innate immune cell types. Transcriptome analysis on differentially developed primary lymphocytes will provide an insight into cell specific expression patterns in innate immune responses and help us to ...

Mark Smyth

Mark Smyth

Updated 24/10/2015

Gene expression in sepsis         As part of my MBiochem degree, I am undertaking a research project looking studying the changes in monocyte gene expression in sepsis. Sepsis is abnormal inflammatory response in response to severe infection. ...

Dr Irina Pulyakhina

Dr Irina Pulyakhina

Updated 12/10/2015

Dr Irina Pulyakhina   We are using functional genomics to understand the mechanism of ankylosing spondylitis (AS), a chronic imflammatory disease with strong genetic predisposition. Recent research has identified Genome-Wide Association ...

Nikhil Faulkner

Nikhil Faulkner

Updated 06/10/2016

                 Genome-Wide Association Studies (GWAS) reveal that 90% of SNPs associated with disease are located in non-coding DNA, highlighting the importance of regulatory variants for disease. Establishing the function and ...

Molly McDonald

Updated 06/10/2016

    For my 4th year research project, I am investigating how certain SNPs (Single Nucleotide Polymorphisms) may affect susceptibility to bacterial infection by Streptococcus group A. SNPs represent small variations in the genomes and have varying ...

Wharton Chan

Wharton Chan

Updated 05/11/2015

HLA typing and its effects in expression patterns     My current project involves investigating the effects of HLA typing on gene expression across a variety of cell types; this involves using genotype and expression (microarray) data that has ...

Dr Daniel Wong

Dr Daniel Wong

Updated 08/01/2012

Functional genomics of the MHC     We are using functional genomic approaches to define genetic variants that are responsible for the association of genetic variation in the Major Histocompatibility Complex (MHC) with susceptibility to ...