Publication date Title /authors November
2008Thomas G Campbell and Navindra Persaud.
The adaptiveness of self-control: simulation of foraging mice
Journal of Comparative Psychology 2008, Vol. 122, No. 4, 368–372 [PMID: 19014260] [Full article (pdf)]July
2008Shifman S, Bhomra A, Smiley S, Wray NR, James MR, Martin NG, Hettema JM, An SS, Neale MC, van den Oord EJ, Kendler KS, Chen X, Boomsma DI, Middeldorp CM, Hottenga JJ, Slagboom PE, Flint J.
A whole genome association study of neuroticism using DNA pooling.
Mol Psychiatry. 2008 Mar;13(3):302-12. (Epub 2007 Jul 31). [PMID: 17667963] [Full article]July
2008Flint J, Shifman S.
Animal models of psychiatric disease.
Curr Opin Genet Dev. July 2008. Epub ahead of print [PMID:18657615 ]July
2008S. Arnold*, G-J. Huang*, A. Cheung, T. Era, S-I. Nishikawa, E. Bikoff, Z. Molnar, E. Robertson, M. Groszer.
The T-box transcription factor Tbr2/Eomes regulates neurogenesis in the cortical subventricular zone.
Accepted by Genes & Development.May
2008The adaptiveness of self-control: simulation of foraging mice.
Accepted by Journal of Comparative Psychology.March
2008Shifman S, Johannesson M, Bronstein M, Chen SX, Collier DA, Craddock NJ, Kendler KS, Li T, O'Donovan M, O'Neill FA, Owen MJ, Walsh D, Weinberger DR, Sun C, Flint J, Darvasi A. (2008).
Genome-Wide Association Identifies a Common Variant in the Reelin Gene That Increases the Risk of Schizophrenia Only in Women.
PLoS Genet. 2008 Feb 15;4(2):e28 [Epub ahead of print] [Full Article] [PMID: 18282107]March
2008Lopez-Aumatell R, Guitart-Masip M, Vicens-Costa E, Gimenez-Llort L, Valdar W, Johannesson M, Flint J, Tobe˜na A, Fernandez-Teruel A. (2008).
Fearfulness in a large N/Nih genetically heterogeneous rat stock: Differential profiles of Timidity and defensive flight in males and females.
Behavioural Brain Research. Volume 188, Issue 1, 17 March 2008, Pages 41-55 [Full Article] [PMID: 18079010]Feb
2008McHugh, S.B., Campbell, T.G., Taylor, A., Rawlins, J.N.P., & Bannerman, D.M.
A Role for the Dorsal and Ventral Hippocampus in Inter-temporal Choice Cost-Benefit Decision Making.
Behavioral Neuroscience. 1: 2008 Feb;122(1):1-8. [Full Article] [PMID: 18298243]Feb
2008Flint J, Shifman S, Munafo M, Mott R.
Genetic variants in major depression.
Novartis Found Symp. 2008;289:23-32; discussion 33-42, 87-93. [PMID: 18497093] [Book details]Feb
2008Fullerton JM, Willis-Owen SA, Yalcin B, Shifman S, Copley RR, Miller SR, Bhomra A, Davidson S, Oliver PL, Mott R, Flint J.
Human-mouse quantitative trait locus concordance and the dissection of a human neuroticism locus.
Biol Psychiatry. 2008 May 1;63(9):874-83. Epub 2008 Feb 20. [PMID:18083140]Jan
2008Munafo MR, Yalcin B, Willis-Owen SA, Flint J (2008)
Association of the Dopamine D4 Receptor (DRD4) Gene and Approach-Related Personality Traits: Meta-Analysis and New Data.
Biological Psychiatry 2008, 63:197-206. [PMID: 17574217] [Full Article]Jan
2008
G-J Huang, D. Bannerman, J. Flint (2008)
Chronic fluoxetine treatment alters behaviour, but not adult hippocampal neurogenesis, in BALB/cJ mice.
Molecular Psychiatry 13, 119-121 [PMID: 18202694] [Full Article]
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FLINT GROUP OVERVIEW
1. News
2. People
3. Research:
4.
Publications
5. Funders
8. Contact us
9. Find us
10. Vacancies
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NEUROGENETICS & PSYCHIATRIC DISORDERS: Psychiatric Genetics Group Professor Jonathan Flint - Group Head
FLINT
GROUP OVERVIEW
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| April | New paper! | Comparing the role of the anterior cingulate cortex and nucleus accumbens dopamine in operant effort-based decision making. In Eur J Neurosci. 2009 Apr;29(8):1678-91 [PMID: 19385990] |
| March | New paper! |
Is there an association
between NPY and neuroticism? Nature. 2009 Apr 2;458(7238):E6; discussion E7. [PMID: 19340021] |
| February | New paper! |
High resolution mapping of expression
QTLs in heterogeneous stock mice in multiple
tissues. Genome Research 19(6):1133-40 |
| January | New paper! |
A
resource for the simultaneous high-resolution
mapping of multiple quantitative trait loci in rats:
the NIH heterogeneous stock. Genome Research. 2009 Jan;19(1):150-8. Epub 2008 Oct 29. [PMID: 18971309] |
2008
November Publication The adaptiveness of self-control: simulation of foraging mice
In Journal of Comparative Psychology 2008 [Full article (pdf)]July
New Project
announcementA major new study on the genetics of major depression in a population of women in China.
The five-year project is funded by a £1.4 million grant from the Wellcome Trust.
The project is collaboration between the University of Oxford, Hua Shan Hospital at Fudan University, China, and the Virginia Commonwealth University (VCU), USA.
[More project information] [VCU Press Release]Publication Animal models of psychiatric disease.
In Curr Opin Genet Dev. [Abstract]Publication A whole genome association study of neuroticism using DNA pooling.
In Molecular Psychiatry. [Full article]Publication Human-mouse quantitative trait locus concordance and the dissection of a human neuroticism locus.
In Biological Psychiatry. [Abstract]New book chapter Genetic variants in major depression.
In Novartis Foundation Symposium 289: Growth Factors and Psychiatric Disorders [Abstract] [Book details]Publication The T-box transcription factor Tbr2/Eomes regulates neurogenesis in the cortical subventricular zone.
In Genes & Development. [Full article]May Publication The adaptiveness of self-control: simulation of foraging mice.
Accepted by Journal of Comparative Psychology. Full article will be available here soon.March Publication Genome-Wide Association Identifies a Common Variant in the Reelin Gene That Increases the Risk of Schizophrenia Only in Women.
PLoS Genet. [Full Article]Publication Fearfulness in a large N/Nih genetically heterogeneous rat stock: Differential profiles of Timidity and defensive flight in males and females.
Behavioural Brain Research. [Full Article]February Publication A Role for the Dorsal and Ventral Hippocampus in Inter-temporal Choice Cost-Benefit Decision Making.
Behavioral Neuroscience. [Full Article]January NARSAD announcement Flint Group initiates new study on the genetics of major depression in a population of women living in Shanghai Publication Chronic fluoxetine treatment alters behavior, but not adult hippocampal neurogenesis, in BALB/cJ mice.
Molecular Psychiatry. [Full Article]Publication Association of the Dopamine D4 Receptor (DRD4) Gene and Approach-Related Personality Traits: Meta-Analysis and New Data.
Biological Psychiatry [Full Article]
2007
Link to all Group publications in 2007
May 2007. NARSAD announcement: Prof Jonathan Flint is awarded the NARSAD 2007 Distinguished Investigator Award
Other press articles:
So You Want Your Child to Be a Genius? Jonathan Flint, PLoS Biology (16th May 2006)
2. People
Professor Jonathan Flint is Head of the Psychiatric Genetics Group at the Wellcome Trust Centre for Human Genetics (WTCHG).
He is a Wellcome Trust Principal Fellow and Michael Davys Professor
3. Research
3.1 Neurogenetics research at the Centre
Neurogenetics is one of the main research areas at the Wellcome Trust Centre for Human Genetics (WTCHG).
There are currently five Research Groups working in this area. [Link to Centre organigram]
3.2 Flint Group - current research
The Flint Group aims to investigate the genetic basis of psychiatric disorders.
We are focusing in particular on the origins of stress-related conditions, such as anxiety and depression.
These disorders currently have relatively ineffective treatments. They are common, disabling and can be difficult to treat. [Further information on depression (from the NARSAD website)]
We have been working on the genetic basis of susceptibility to anxiety and depression for over a decade. [For non-scientists: more here on understanding genetic disorders]
Recent scientific advances are making it increasingly possible to analyse the role that specific genes play in psychiatric disorders. [For non-scientists: more here on techniques for investigating genetic disorders]
This site contains more detailed information about the work we do. Please have a look!
More herE: our research projects
New Project! CONVERGE 1 - "Study of Major Depression in Chinese Women"
4. Publications
4.1 Most recent publications (2007-2008):
Publication date Title /authors New!
April
2009Comparing the role of the anterior cingulate cortex and nucleus accumbens dopamine in operant effort-based decision making
Walton ME, Groves J, Jennings KA, Croxson PL, Sharp T, Rushworth MF, Bannerman DM.
Eur J Neurosci. 2009 Apr;29(8):1678-91 [PMID: 19385990]New!
April
2009Cotton CH, Flint J, Campbell TG.
Is there an association between NPY and neuroticism?
Nature. 2009 Apr 2;458(7238):E6; discussion E7. [PMID: 19340021]New!
February
2009Mark E. Walton, James Groves, Katie A. Jennings, Paula L. Croxson, Trevor Sharp, David M. Bannerman, Matthew F. S. Rushworth
Comparing the role of the anterior cingulate cortex and nucleus accumbens dopamine in operant effort-based decision making
European Journal of Neuroscience (accepted)New!
February
2009G-J. Huang, S. Shifman, M. Johannesson, B. Yalcin, W. Valdar, J. Taylor, R. Mott, J. Flint. (2009).
High resolution mapping of expression QTLs in heterogeneous stock mice in multiple tissues.
Genome Research 19(6):1133-40January
2009Johannesson M, Lopez-Aumatell R, Stridh P, et al
A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: the NIH heterogeneous stock.
Genome Research. 2009 Jan;19(1):150-8. Epub 2008 Oct 29. [PMID: 18971309]
4.2 List of all publications
5. Funders
The Flint Group is currently receiving grants from the following funders:
6. Research consortia
Flint Group researchers are members of the following research consortia and international projects:
7. Links / Further information
7.1 Further information:
For scientists:
For non-scientists:
7.2 Links:
Oxford University / WTCHG:
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Wellcome Trust Centre for Human Genetics (WTCHG): home page
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WTCHG: Bioinformatics and Statistical Genetics Research Group
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Oxford University: home page
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Oxford University: Oxford Neuroscience website
Collaborating institutions
Other links
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NARSAD: mental health research charity
8. Contact
For general enquiries to the Flint Group: jf@well.ox.ac.uk
9. How to find us
10. Vacancies
If you are interested in joining our group
please contact us!
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Page last updated on Mon Jul 13 17:18:36 2009 |