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Neurogenetics

Professor George C. Ebers
Action Research Professor of Clinical Neurology

Publications of the group

Recent key work of the group can be seen in the following manuscripts:

1. Ebers GC. Environmental factors and multiple sclerosis. Lancet Neurology 2008;7(3):268-277

2. Herrera BM, Ramagopalan SV, Lincoln MR, Orton SM, Chao MJ, Sadovnick AD, Ebers GC."Parent-of-origin effects in MS: observations from avuncular pairs." Neurology. 2008 Sep 9;71(11):799-803.

3. Chao MJ, Barnardo MC, Lincoln MR, Ramagopalan SV, Herrera BM, Dyment DA, Montpetit A, Sadovnick AD, Knight JC, Ebers GC. "HLA class I alleles tag HLA-DRB1*1501 haplotypes for differential risk in multiple sclerosis susceptibility." Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13069-74.

4. Aulchenko YS, Hoppenbrouwers IA, Ramagopalan SV, Broer L, Jafari N, Hillert J, Link J, Lundström W, Greiner E, Dessa Sadovnick A, Goossens D, Van Broeckhoven C, Del-Favero J, Ebers GC, Oostra BA, van Duijn CM, Hintzen RQ. "Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis." Nat Genet. 2008 Dec;40(12):1402-3.

5. DeLuca GC, Ramagopalan SV, Herrera BM, Dyment DA, Lincoln MR, Montpetit A, Pugliatti M, Barnardo MC, Risch NJ, Sadovnick AD, Chao M, Sotgiu S, Hudson TJ, Ebers GC. An extremes of outcome strategy provides evidence that multiple sclerosis severity is determined by alleles at the HLA-DRB1 locus. Proceedings of the National Academy of Sciences of the USA 2007 26;104(52):20896-901.

6. Ramagopalan SV, Dyment DA, Morris AP, Herrera BM, DeLuca GC, Lincoln MR, Orton SM, Chao MJ, Sadovnick AD, Ebers GC, "The Inheritance of Resistance Alleles in Multiple Sclerosis", PLoS Genetics 2007; 3(9): 1607-1613

7. DeLuca GC, Williams K, Evangelou N, Ebers GC, Esiri MM. The contribution of demyelination to axonal loss in multiple sclerosis. Brain 2006 129:1507-1516.

8. Orton SM, Herrera BM, Valdar W, Yee IM, Ramagopalan SV, Sadovnick AD, Ebers GC. Sex ratio of multiple sclerosis in Canada: a longitudinal study. Lancet Neurol 2006 5:932-936

9. Kremenchutzky M, Rice GPA, Baskerville J, Wingerchuk DM, Ebers GC. The natural history of multiple sclerosis: a geographically based study IX. Observations on the progressive phase of the disease. Brain 2006 129(Pt 3): 584-594.

10. Dyment DA, Herrera BM, Cader MZ, Willer CJ, Lincoln KR, Sadovnick AD, Risch N, Ebers GC. Complex interactions among MHC haplotypes in multiple sclerosis: susceptibility and resistance Hum Mol Genet 2005 14(14):2019-2026

11. Lincoln MR, Montpetit A, Cader M Z, Saarela J, Dyment DA, Tiislar M, Ferretti V, Risch NJ, Peltonen L, Ebers GC, Hudson TJ. A predominant role for the HLA classs II region in the association of the MHC region with multiple sclerosis. Nat Genet 2005 37(10):1108-1112.

12. Ebers GC, Sadovnick AD, Dyment DA, Yee IML, Willer CJ, Risch N. Parent-of-origin effect in multiple sclerosis: observations in half-siblings. Lancet 2004 363: 1773-1774

Last updated December 2008